Organometallic Ligands

PF-04929113 (Mesylate) is a small molecule inhibitor, which is derived from synthetic sources, designed to target the phosphoinositide 3-kinase (PI3K) pathway with high specificity and potency. This compound exerts its mode of action through the inhibition of PI3K activity, a pivotal signaling molecule involved in multiple cell processes including growth, metabolism, and survival. By blocking PI3K, PF-04929113 disrupts downstream signaling pathways, leading to reduced cellular proliferation and inducing apoptosis in cancer cells. Researchers primarily use PF-04929113 in preclinical studies to investigate its therapeutic potential in various malignancies where PI3K signaling is dysregulated, such as breast, ovarian, and prostate cancers. Its selective inhibition of PI3K offers insights into the development of targeted cancer therapies and enhances understanding of oncogenic signaling pathways. The compound's efficacy and specificity make it a valuable tool in cancer biology, enabling scientists to dissect complex cellular processes and explore novel therapeutic interventions.

Tenoxicam is a non-steroidal anti-inflammatory drug that is used to reduce pain and inflammation in conditions such as arthritis. This drug works by inhibiting the enzyme cyclooxygenase or COX. As a result of this inhibition, this drug reduces the production of prostaglandins and therefore leads to a decrease in pain and inflammation. Tenoxicam is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

(3aS)-3a-Hydroxy-1-(3-hydroxyphenyl)-6-methyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-one is an alkaloid compound, which is characterized by its complex polycyclic structure. Derived from natural sources such as plant species or synthesized through advanced organic chemistry techniques, this compound demonstrates potential through its complex pharmacodynamics. It exhibits activity by interacting with specific biological receptors, influencing signal transduction pathways, and modulating enzyme activities, thereby eliciting a variety of physiological responses. In scientific research, (3aS)-3a-Hydroxy-1-(3-hydroxyphenyl)-6-methyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-one is primarily explored for its pharmacological applications, possibly offering therapeutic benefits in areas such as oncology or neurology. Its ability to modulate cellular and molecular mechanisms makes it a point of interest in drug development and medicinal chemistry. Ongoing studies aim to elucidate its full spectrum of biological activities, safety profile, and therapeutic potential for future clinical applications.

SNIPER(ABL)-033 is an advanced biotechnological tool designed to facilitate targeted research interventions. It is sourced from a collaborative effort between molecular biology specialists and biochemical engineers, ensuring robustness in complex biological environments. The product operates via advanced Antibody-Based Ligand (ABL) technology, which allows for the precise targeting and modulation of specific cellular pathways. Its mode of action involves binding to distinct molecular markers, facilitating targeted interference or activation of biological processes with high specificity and minimized off-target effects. SNIPER(ABL)-033 finds its applications primarily in the fields of cancer research, gene editing, and signal transduction studies. It enables scientists to dissect intricate biological pathways with enhanced accuracy, providing critical insights into cellular function and pathology. Its innovative approach aids in elucidating the mechanisms underlying disease progression and therapeutic responses, making it an indispensable tool in both basic and applied research settings.

Bis-imidazole phenol IDH1 inhibitor is a small-molecule therapeutic, which is a novel compound synthesized to specifically target mutant forms of isocitrate dehydrogenase 1 (IDH1). It operates by binding to the mutant IDH1 enzyme and inhibiting its aberrant function, which involves converting alpha-ketoglutarate to an oncometabolite, 2-hydroxyglutarate (2-HG). This conversion leads to epigenetic changes that drive the tumorigenesis process. The utility of Bis-imidazole phenol IDH1 inhibitors lies in their potential applications within oncology, specifically for treating cancers harboring IDH1 mutations, such as certain gliomas and acute myeloid leukemia. By reducing the production of 2-HG, these inhibitors aim to reverse the epigenetic reprogramming of cancer cells, thereby inhibiting tumor growth and progression. This targeted approach offers a promising direction for personalized cancer therapy, helping to improve outcomes for patients with mutant IDH1-associated malignancies. Researchers continue to explore the pharmacokinetic properties, efficacy, and safety profiles of these compounds in pre-clinical and clinical settings to fully understand their therapeutic potential.

CP 94253 Hydrochloride is a selective 5-HT1B receptor agonist, which is a synthetic compound derived through chemical synthesis in laboratory settings. Its mode of action involves selectively binding to and activating the 5-HT1B serotonin receptors, which play a significant role in the modulation of neurotransmitter release in the central nervous system. This receptor interaction influences serotonin levels, impacting various neurological pathways. The primary use and application of CP 94253 Hydrochloride lie in neuroscience research, where it serves as a critical tool for exploring serotonergic system functions and their implications in mood disorders, pain perception, and other neurological conditions. Research on CP 94253 Hydrochloride contributes to a deeper understanding of serotonin's role in the brain and the potential development of novel therapeutic agents targeting serotonin receptors. Additionally, this compound may be used in experimental pharmacology to investigate receptor-specific pathways and their wider physiological effects.

AZD 7762 Hydrochloride is a small-molecule inhibitor, which is a synthetic compound designed to target specific molecular pathways. It is manufactured as a hydrochloride salt for increased stability and solubility. The product principally acts by inhibiting checkpoint kinases, specifically Chk1 and Chk2, which play critical roles in the DNA damage response pathway. By inhibiting these kinases, AZD 7762 disrupts the cell cycle checkpoint control, leading to the accumulation of DNA damage in cancer cells, ultimately inducing apoptosis. This compound has been extensively studied for its potential in cancer therapy. Its ability to sensitize tumor cells to DNA-damaging agents and radiation makes it a promising candidate for combination therapy in oncology. Research has focused on its application in various cancer types, including pancreatic and lung cancers, where it enhances the efficacy of chemotherapeutic agents. The ongoing investigation aims to further elucidate its pharmacodynamics, optimize dosing regimens, and explore its full therapeutic potentials.

BMS-582949 is an investigational pharmaceutical compound, specifically a chemokine receptor antagonist, that has been derived through synthetic chemical processes. Its mode of action involves selectively inhibiting the C-C chemokine receptor type 2 (CCR2), a receptor involved in the migration and activation of monocytes and other immune cells. By blocking CCR2, BMS-582949 aims to modulate inflammatory pathways that are implicated in various diseases. This compound has been explored for its potential applications in treating inflammatory conditions, owing to its ability to interfere with chemokine-driven immune cell infiltration into tissues. Such applications could include the management of disorders such as rheumatoid arthritis and other chronic inflammatory diseases. While still in the experimental phase, BMS-582949 represents a targeted approach to managing inflammation by disrupting specific immune signaling pathways, thereby potentially offering a novel therapeutic avenue distinct from traditional anti-inflammatory drugs.

Iron chelator

Selectively inhibits α- and ζ-thrombins and elicits procoagulant effects. Reduces platelet deposition in a rat carotid endarterectomy model. Has therapeutic potential as an anti-thrombotic agent in patients with heparin-associated thrombosis.

Peroxy Orange 1 is an advanced cleaning agent, which is a hydrogen peroxide-based product enriched with surfactants and orange oil extracts. This formulation originates from a blend of both synthetic and natural sources, integrating the oxidizing power of hydrogen peroxide with the cleaning efficacy of citrus oils. Peroxy Orange 1 operates through the oxidative capabilities of hydrogen peroxide, which breaks down into water and oxygen. This decomposition releases free radicals that attack and degrade organic matter, effectively lifting stains and disinfecting surfaces. The addition of orange oil enhances its cleaning properties by dissolving grease and imparting a refreshing aroma. This product is primarily utilized for its effectiveness in industrial and research settings for cleaning surfaces contaminated with organic residues. Its applications span lab environments, healthcare institutions, and facilities demanding stringent hygiene standards. The synergy between its components ensures a comprehensive cleaning mechanism, addressing both microbial contamination and the removal of organic debris, without leaving harmful residues. This makes Peroxy Orange 1 particularly suited for scenarios where both effective cleaning and environmental safety are paramount.

AP 1903 is a synthetic small molecule, which acts as a dimerizer ligand. It is derived from the modification of the macrolide antibiotic rapamycin to remove its immunosuppressive effects, thus enabling targeted control of cellular processes. The mode of action involves binding to engineered receptors on the cell surface that contain drug-dependent domains. This binding triggers the dimerization of these receptors, leading to downstream signaling and subsequent cellular responses. AP 1903 is utilized primarily in research settings for its capacity to regulate cellular functions with high precision. It is often employed in experimental systems where temporal control over gene expression or cellular behavior is necessary. This allows scientists to study complex cellular pathways and perform controlled manipulations of cellular actions in various model organisms. Through its specific interaction with engineered receptors, AP 1903 provides a powerful tool for elucidating the roles of specific signaling pathways in cell biology and for developing potential therapeutic strategies.

1-Desoxymethylsphingosine is a synthetic compound, which is derived from sphingosine analogs, designed for research purposes. As a chemical entity, it is typically synthesized in laboratories specializing in lipid chemistry. The mode of action of 1-Desoxymethylsphingosine involves the inhibition of enzymes involved in sphingolipid metabolism, primarily targeting the sphingosine kinase pathway. This inhibition affects the regulation of bioactive sphingolipids, which play crucial roles in cell signaling and apoptosis. The uses and applications of 1-Desoxymethylsphingosine are predominantly in biomedical research. Scientists utilize this compound to study the biochemical pathways of sphingolipids, providing insights into their roles in various cellular processes and potential implications in diseases such as cancer, neurodegenerative disorders, and inflammatory conditions. By inhibiting specific enzymes, researchers can dissect the complex network of lipid signaling, aiding in the identification of therapeutic targets and the development of novel therapeutic strategies.

Gonadotropin-releasing hormone agonist

S 32212 hydrochloride is a selective serotonin receptor antagonist, which is synthesized chemically. Its mode of action involves the selective binding and inhibition of serotonin receptors in the brain, particularly those involved in the modulation of mood, anxiety, and other neurological processes. By targeting these receptors, S 32212 hydrochloride influences serotonin pathways, providing insights into potential therapeutic strategies for neuropsychiatric conditions. S 32212 hydrochloride is utilized primarily in research settings to investigate the complex roles serotonin receptors play in neurobiology. It aids in elucidating the mechanisms underlying mood disorders, offering valuable data for the development of novel antidepressant or anxiolytic agents. The compound serves as a tool for scientists exploring the neuropharmacology of serotonin systems and their impact on behavioral and physiological responses.

Doxepin is a psychotropic agent that is used in the treatment of depression, anxiety and insomnia. This drug has antidepressant and anxiolytic properties. This mechanism of action for this drug is not clear however it is known to be a histamine receptor antagonist. Doxepin HCl is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Aminosteroid; neuromuscular blocker in anaesthetics

Vipivotide tetraxetan is a radioactive therapeutic agent, which is a radioligand conjugate composed of a DOTA chelator linked to a targeting moiety. The source of this compound lies in its synthesis, where the DOTA ligand is conjugated to a peptide or small molecule that targets specific cell surface antigens expressed on cancer cells. The mode of action involves the targeted delivery of a radioactive isotope directly to cancer cells. Once the linker binds to the desired target, the radioactive component emits radiation, leading to DNA damage and the subsequent death of the targeted cells. This highly targeted approach allows for minimizing damage to surrounding healthy tissue, a significant advantage over conventional radiotherapy. Vipivotide tetraxetan is used primarily in the treatment of certain types of cancers, notably those expressing the specific cell surface markers the ligand targets. Its applications are primarily in clinical settings where precise targeting of malignant cells is necessary, often employed in cases where tumors have proven resistant to standard treatments. This approach represents a cutting-edge advancement in personalized medicine, offering a tailored therapeutic option with the potential for improved efficacy and reduced toxicity.

PS210 is a highly advanced chemical compound, which is a synthetic catalyst designed for precision-driven applications in chemical laboratories. It is derived from a meticulous synthesis process involving transition metals and organic ligands. The mode of action of PS210 involves facilitating specific chemical reactions by lowering the activation energy, thereby increasing reaction rates without being consumed in the process. The uses and applications of PS210 are extensive and notably valuable in areas such as organic synthesis, industrial catalysis, and materials science research. It serves a crucial role in accelerating reactions in the synthesis of complex molecules, offering enhanced efficiency and selectivity. Additionally, PS210 is instrumental in sustainable chemistry processes, contributing to reduced energy consumption and minimized waste generation in large-scale chemical manufacturing. Its reliability and effectiveness make it a cornerstone for scientists seeking to innovate and optimize their experimental pathways.

Fenpiverinium is an anticholinergic and antispasmodic agent that is used to treat muscle spasms and pain. Fenpiverinium inhibits the production of acetylcholine at muscarinic receptors by inhibiting cholinesterase enzymes. Also it has an effect on autoimmune diseases and non-immune-related diseases such as lupus erythematosus, rheumatoid arthritis, psoriasis, and Crohn's disease. It is also effective against pain caused by diabetes mellitus. Fenpiverinium bromide is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.