Organometallic Ligands

Inhibits acetylcholinesterase (AChE); antispasmodic agent

SR 59230A hydrochloride is a selective beta-3 adrenergic antagonist, which is synthesized chemically. It is commonly used in research settings to investigate the role and functioning of beta-3 adrenergic receptors. The compound operates by effectively blocking these specific receptors, which are primarily found in adipose tissue and the heart, and are involved in energy homeostasis and cardiovascular regulation. The primary use of SR 59230A hydrochloride is in experimental studies exploring metabolic and cardiovascular processes. Researchers utilize this compound to elucidate the function of beta-3 adrenergic receptors in various physiological and pathological states, such as obesity, diabetes, and heart failure. Its ability to selectively target these receptors makes it an invaluable tool in pharmacological studies aimed at better understanding receptor-specific actions without interference from other adrenergic receptors. This specificity facilitates the development of potential therapeutic approaches aimed at modulating energy balance and cardiovascular health.

Temozolomide is a cancer drug that belongs to the class of alkylating agents. It has been shown to have anticancer activity against human tumor cells in vitro. Temozolomide induces cell death by activating the apoptotic pathway. This drug also inhibits the cell cycle and blocks the G2-M phase, resulting in accumulation of cells at this point in the cell cycle. Temozolomide has been studied for its effects for cancer treatment in certain research approaches.

1-Stearoyl-2-[(E)-4-(4-((4-butylphenyl)diazenyl)phenyl)butanoyl]-sn-glycero-3-phosphocholine is a synthetic phospholipid, which is derived from glycerophosphocholine with the incorporation of a stearoyl chain and a diazenyl-functionalized butanoyl chain. This modification confers unique photoresponsive properties to the phospholipid, enabling it to undergo conformational changes in response to specific light wavelengths. The primary mechanism of action involves the reversible trans-cis isomerization of the azobenzene group upon exposure to UV and visible light. This photochemical response allows for precise control over molecular orientation and assembly, making it a valuable tool for the study of dynamic membrane processes and nanomaterial design. Applications of this compound are primarily within research domains such as biophysics and materials science. It is used to investigate the behavior of lipid membranes under variable conditions and explore the development of light-responsive systems. Its role extends to the creation of smart materials and drug delivery systems where controlled release is desirable. This product thus offers a versatile platform for researchers aiming to manipulate molecular architecture through external stimuli.

Carbidopa ethyl ester hydrochloride is a biochemical compound that acts as a prodrug of carbidopa, often used in neurological studies. It is synthesized through the modification of carbidopa, itself a derivative of the amino acid hydrazine, by adding ethyl ester and hydrochloride groups to enhance its properties. The primary role of Carbidopa ethyl ester hydrochloride is to inhibit aromatic L-amino acid decarboxylase. This inhibition increases the bioavailability of levodopa by preventing its premature conversion to dopamine outside the central nervous system. This selective mechanism allows levodopa to reach the brain more efficiently, where it is needed for dopamine synthesis. This compound is of significant interest in neurological research, specifically in the study of Parkinson's disease. By aiding in the effective delivery of levodopa, Carbidopa ethyl ester hydrochloride helps researchers better understand treatment paths and the biochemical behavior of Parkinson's-related therapies. It is also useful in investigating the pharmacokinetics and pharmacodynamics of levodopa-related compounds, potentially leading to new therapeutic interventions.

Protective agent against mercuric chloride poisoning

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12:0(2S-OH) ceramide is a bioactive lipid molecule, which is a type of ceramide characterized by a specific chemical structure denoted by its 12 carbon atoms and a 2S-hydroxy group. It is derived from sphingolipids, typically sourced from cellular membranes where sphingolipids are major components. Ceramides are integral to the maintenance of the structural integrity of cell membranes and are involved in diverse cellular functions. The mode of action of 12:0(2S-OH) ceramide involves its role as a secondary messenger in cell signaling pathways. It modulates various biochemical cascades by influencing intracellular signaling processes, potentially affecting cell proliferation, differentiation, apoptosis, and stress responses. This regulation is vital for maintaining cellular homeostasis and responding to external environmental changes. In scientific research and applied sciences, 12:0(2S-OH) ceramide is utilized primarily to study its effects on cellular metabolism and as a model compound to explore the functional roles of ceramides in diseases such as cancer, neurodegeneration, and skin disorders. Researchers often investigate its potential as a therapeutic target or biomarker, aiming to elucidate its role in disease mechanisms and development.

nAChRs nicotinic receptor antagonist; neuromuscular-blocking agent

Spla2-X Inhibitor 31 is a chemical inhibitor specifically targeting the human secreted phospholipase A2 group X (sPLA2-X), which is derived synthetically through chemical synthesis. Its mode of action involves binding to the active site of sPLA2-X, effectively blocking its enzymatic activity. This enzyme catalyzes the hydrolysis of phospholipids, leading to the release of arachidonic acid, a precursor for bioactive lipids involved in inflammation and other cellular processes. The utility of Spla2-X Inhibitor 31 spans various applications in biomedical research, particularly in the study of inflammation, osteoporosis, and cardiovascular diseases where excessive sPLA2-X activity contributes to pathological states. By inhibiting this enzyme, researchers can delineate its role in disease mechanisms and investigate potential therapeutic interventions. Furthermore, its use in vitro can aid in understanding the enzyme-substrate interactions and regulatory pathways linked to phospholipid metabolism.

17:0-20:4 Pi (3,5) P2 is a phospholipid with pharmacological properties. It is a potent activator of the nicotinic acetylcholine receptor. This peptide binds to the alpha subunit of the acetylcholine receptor and causes the channel to open more quickly, leading to an increased influx of calcium ions. 17:0-20:4 Pi (3,5) P2 is also an inhibitor of ion channels. This molecule has been shown to inhibit voltage-gated potassium channels and L type calcium channel currents in neurons.

Alfuzosin is an alpha-1 adrenoreceptor antagonist drug that is used in treatment and management of benign prostatic hyperplasia. This drug works by relaxing the muscles in the prostate and bladder neck which results in symptom improvement. Alfuzosin is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Prostaglandin F2α receptor agonist

Short acting monoamine oxidase inhibitor

Pi3K/mTOR Inhibitor-2 is a synthetic small molecule, which is a highly specific chemical inhibitor. It is designed to simultaneously target and inhibit the phosphoinositide 3-kinase (Pi3K) and mechanistic target of rapamycin (mTOR) pathways. The source of Pi3K/mTOR Inhibitor-2 is entirely derived from lab-based chemical synthesis, ensuring a consistent and controlled formulation conducive to experimental reproducibility. The mode of action of Pi3K/mTOR Inhibitor-2 involves the blockade of the catalytic activity of Pi3K and mTOR kinases. By inhibiting these pathways, it effectively disrupts key signaling cascades involved in cellular growth, proliferation, and survival, making it a potent tool for elucidating the complex interactions within the Pi3K-AKT-mTOR axis. This inhibitor is extensively used in oncology research to study cancer progression and therapeutic resistance mechanisms. Additionally, it is applied in investigations related to metabolic disorders and neurodegenerative diseases, where the Pi3K/mTOR pathways play crucial roles. The dual inhibition capability of Pi3K/mTOR Inhibitor-2 makes it an invaluable component in the development of novel therapeutic strategies.

PZ-2891 is a small molecule inhibitor, which is a synthetic compound derived through chemical synthesis with precision engineering. It operates by selectively inhibiting the enzyme poly(ADP-ribose) glycohydrolase (PARG), which plays a critical role in the repair of DNA single-strand breaks. By targeting PARG, PZ-2891 modulates the cellular response to DNA damage, thus influencing DNA repair pathways. The uses and applications of PZ-2891 are primarily focused on neurological research and potential therapeutic interventions. In experimental settings, PZ-2891 has demonstrated promise in preclinical models of neurodegenerative diseases, including those involving abnormal DNA repair mechanisms. Researchers are actively investigating its efficacy and safety profiles, seeking to understand its potential in modulating disease progression and improving cellular resilience. Ongoing studies aim to elucidate its broader impact on cellular homeostasis and its potential synergy with existing treatment modalities. Understanding PZ-2891's action could unveil new avenues for therapeutic development in addressing complex neurological disorders.

ML 382 is an advanced chemical compound, which is a synthetic small molecule derived from a complex organic chemistry process. It acts primarily through modulation of specific enzymatic pathways, enabling precise control over biochemical reactions. The core mechanism of ML 382 involves selective binding to target enzymes, altering their activity, which provides a valuable tool for probing cellular functions. The compound has been shown to impact pathways involved in cellular signaling and metabolism, making it highly significant in the field of biochemical research. Applications of ML 382 are extensive, particularly in research domains requiring the modulation of signal transduction pathways. Scientists utilize ML 382 to dissect molecular mechanisms underlying various physiological and pathological processes. This compound is instrumental in developing novel therapeutic strategies and understanding disease mechanisms at a molecular level. Through its precise mode of action, ML 382 serves as a pivotal tool in advancing knowledge in biochemistry and molecular biology.

Inhibits histone deacetylase (HDAC)

Acetylcholinesterase inhibitor; therapy for Alzheimer's disease

Crkl, His tagged human is a recombinant fusion protein, which is sourced from engineered human cells. It is designed to include a histidine tag, facilitating affinity purification and detection in research applications. This protein acts as an adaptor in intracellular signaling pathways, primarily involved in the transduction of extracellular signals into cellular responses. It plays a crucial role in various biological processes, including cell proliferation, migration, and differentiation, by interacting with other proteins and initiating downstream signaling cascades. In scientific research, Crkl, His tagged human is utilized for studying complex signaling networks in both normal and pathological states. It provides insights into the molecular mechanisms underlying diseases such as cancer and immune disorders. By facilitating investigations into how signals are propagated within cells, this protein assists researchers in identifying potential therapeutic targets and understanding cellular behaviors in response to external stimuli.