Organometallic Ligands

Tadalafil analogue; PDE 5 inhibitor

Imatinib is a tyrosine kinase inhibitor drug that is used for the treatment of various leukaemias, gastrointestinal stromal tumours and myeloproliferative disease. This drug inhibits the BCR-ABL tyrosine kinase and thus prevents the downstream phosphorylation of target proteins. This drug also inhibits PDGF, SCF and c-kit. Imatinib mesylate is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Atenolol is a beta-blocker that slows the heart rate and decreases the force of contraction, which reduces the workload on the heart. Atenolol has been shown to be effective in lowering blood pressure in people with chronic kidney disease who are not taking angiotensin-converting enzyme inhibitors. It is also used to treat hypertension and chronic angina. Atenolol is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Rabeprazole is a proton pump inhibitor drug that is used to treat symptoms of GERD, heal gastrointestinal ulcers and eradicate Helicobacter pylori. This antiulcer drug suppresses gastric acid by inhibiting the gastric H+/K+ ATPase at the parietal cell. Rabeprazole sodium salt is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

2-((2,6-Dimethoxy-4-(2-methyl-1-oxo-1,2-dihydro-2,7-naphthyridin-4-yl)benzyl)(methyl)amino)-N-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethyl)acetamide is a synthetic bioactive compound, which is developed through intricate organic synthesis processes. This compound functions primarily through the modulation of specific molecular pathways, such as protein-protein interactions or enzyme activity, potentially altering cellular processes. It may exhibit properties that interfere with particular signaling cascades or molecular targets, thus influencing their biological outcomes. The applications of this compound could span across various research domains, particularly in pharmacological studies where it may serve as an investigational tool to probe biological systems or as a lead compound in drug development efforts against diseases where its target pathways are implicated. Scientists in medicinal chemistry and pharmacology might find this compound especially relevant for experiments seeking novel therapeutic interventions or mechanistic insights into complex biological phenomena.

Ki696 isomer is a peptide that has been found to be an inhibitor of protein interactions. It has been shown to inhibit the binding of Ligand and Receptor, as well as the activation of protein, by binding to its receptor site. Ki696 isomer is also a cell biology research tool, used for studying ion channels and antibodies. This compound does not contain any heavy metals or radioactive substances. It was originally synthesized at the CAS No. 1799974-69-8 in China.

Roflumilast is a selective phosphodiesterase-4 inhibitor that is used for the treatment of exacerbations in patients with chronic obstructive pulmonary disease (COPD). It is also used to treat plaque psoriasis. This drug has anti-inflammatory and immunomodulatory effects as it aids in increasing levels of cAMP. Roflumilast is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

5-(4-Methoxyphenyl)-N-(1-methyl-4-(3-pyridinyl)butyl)-2,4-decadienamide is a bioactive compound derived from specific plant sources. This chemical entity functions primarily through modulation of biological pathways, notably influencing signal transduction and cellular responses. Its mode of action involves interaction with specific receptors and enzymes, affecting processes such as inflammation and neural activities. The compound finds applications in pharmacological research and development, where it is explored for its potential therapeutic effects in a range of conditions, including neurodegenerative disorders and inflammatory diseases. The unique structural attributes of the molecule offer opportunities for detailed investigation into receptor binding and mechanism elucidation, thus contributing to the broader understanding of its therapeutic potential and paving the way for future clinical applications.

1-[4-[6-[6-[(2R)-2-(3-Fluorophenyl)pyrrolidin-1-yl]imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl]pyridin-2-yl]piperidin-4-ol is a bioactive small molecule, typically synthesized in laboratories focusing on medicinal chemistry. This compound is specifically designed to interact with biochemical targets, usually proteins or receptors, to modulate their activity. Its mode of action involves binding to specific sites on these targets, potentially leading to inhibition, activation, or alteration of the target's natural function, depending on the desired therapeutic outcome. The applications of this compound are mainly situated in the realm of drug discovery and development, serving as a lead or candidate in the pursuit of effective therapies for conditions that involve the targeted pathways or receptors. Researchers analyze such compounds to assess their efficacy, selectivity, and therapeutic potential in disease models, which is critical in the preclinical stage of drug development.

CY3 is a fluorescent dye, which is derived from the cyanine family of compounds with a specific excitation/emission spectrum. It operates by fluorescing when exposed to certain wavelengths of light, typically around 554 nm for excitation and 568 nm for emission. This spectral property allows it to be used as a powerful molecular probe. The primary applications of CY3 revolve around biological labeling techniques, such as fluorescence microscopy and flow cytometry. It is used to label nucleic acids, proteins, or other cellular components, allowing for visualization and analysis of biological processes at the molecular level. CY3's stable and bright fluorescence makes it an ideal choice for single or multiplex labeling, facilitating detailed cellular and molecular studies. It is particularly favored in applications requiring long-lasting and intense fluorescent signals. In summary, CY3's utility in scientific research enhances our understanding of cellular dynamics and molecular interactions, contributing significantly to advances in areas such as genomics, proteomics, and cell biology.

Please enquire for more information about FAPI-46 trifluoroacetate including the price, delivery time and more detailed product information at the technical inquiry form on this page

γ-secretase inhibitor; reduces amyloid-β in brainÂ

CUDC-427 is a small-molecule inhibitor of apoptosis proteins (IAP), which is a synthetic compound sourced from the design and synthesis of targeted anticancer agents. Its primary mode of action involves the selective inhibition of IAPs, particularly cIAP1 and cIAP2. This inhibition leads to the activation of caspases and subsequent induction of apoptosis in cancer cells. CUDC-427 is primarily utilized in research focused on cancer treatment, offering potential therapeutic applications by promoting apoptosis in tumor cells that have developed resistance to other forms of treatment. It is particularly of interest in studies involving malignancies such as breast cancer, ovarian cancer, and various hematological cancers. The compound's ability to sensitize cancer cells to existing treatments makes it a valuable tool in developing combination therapies, enhancing the efficacy of chemotherapeutic agents and potentially improving patient outcomes. Research into CUDC-427 continues to explore its full clinical potential, including its pharmacokinetics, safety profile, and effectiveness across different cancer types.

(4R)-2-Undecyl-4-thiazolidinecarboxylic acid is a synthetic compound, which is often used as a chemical reagent. Derived from thiazolidine, it is formed through the cyclization of an aldose or ketose with cysteamine. Its mode of action involves the scavenging of free radicals; this thiol-containing compound can neutralize reactive oxygen species, thereby preventing cellular damage. The compound is employed extensively in biochemical research to study oxidative stress and its effects on cellular pathways. Its antioxidant properties make it useful for probing mechanisms of oxidative damage and repair. Additionally, this compound has been used in various studies aiming to develop treatments for conditions where oxidative stress is a major contributing factor, such as neurodegenerative diseases and inflammatory disorders. Its ability to mitigate oxidative stress also holds promise for potential therapeutic applications, making it a valuable tool in pharmacological research.

14-3-3 Ε, Untagged human, is a recombinant protein expressed in Escherichia coli, which is derived from human sources. This protein belongs to the 14-3-3 family, known for regulatory roles in diverse biological processes, primarily involving protein-protein interactions that modulate the function of its bound targets. It operates by binding to phosphorylated serine and threonine residues, thereby influencing signal transduction pathways critical for cellular processes such as apoptosis, cell cycle regulation, and stress response. Through its interaction with various signaling proteins, the 14-3-3 Ε protein ensures proper cellular function and integrity. This protein is widely used in scientific research to study cell signaling pathways, protein interactions, and mechanisms of disease at the molecular level. Its applications extend to cancer research, neurobiology, and the study of metabolic disorders, where understanding the modulation of signaling networks is crucial. Scientists utilize 14-3-3 Ε to unravel the complexities of cell regulation and develop targeted therapeutic strategies.

Losartan is an angiotensin receptor drug that is used to treat hypertension. It works by blocking the activity of angiotensin II binding to the AT1 receptor. As a result, this causes vascular smooth muscle relaxation and lowers blood pressure. Losartan potassium is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Palbociclib dihydrochloride is a selective inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6), which is derived from synthetic chemical processes. Its mode of action involves disrupting the progression of the cell cycle from G1 to S phase, thereby inhibiting cellular proliferation. By specifically targeting and inhibiting CDK4/6, Palbociclib effectively arrests the growth of cancer cells that rely on these kinases for division. This compound is primarily utilized in the treatment of hormone receptor-positive, HER2-negative advanced or metastatic breast cancer. It is often administered in combination with endocrine therapy, such as letrozole or fulvestrant, to enhance therapeutic efficacy. Research into its precise mechanisms highlights its role in restoring control over aberrant signaling pathways involved in cell cycle dysregulation, making it a key player in modern oncological treatment strategies. The introduction of Palbociclib represents a significant advancement in targeted cancer therapy, providing new avenues for managing certain subtypes of breast cancer with improved specificity and reduced systemic toxicity.

GNE-495 is a small molecule inhibitor, which is synthetically derived through medicinal chemistry processes. Its mode of action involves targeting specific kinase pathways that are crucial for the proliferation and survival of cancer cells. By inhibiting these kinases, GNE-495 disrupts signaling pathways, leading to reduced tumor growth and potential apoptosis in malignant cells. The applications of GNE-495 predominantly lie in oncology research. It is utilized in preclinical studies to determine its efficacy in suppressing tumor growth across various cancer models. Researchers are particularly focused on exploring its potential synergy with other therapeutic agents and its effectiveness across different cancer types. Understanding its pharmacokinetics and pharmacodynamics also forms a critical part of current scientific investigations. This compound is instrumental in elucidating the complexities of kinase signaling pathways, thereby advancing the development of targeted cancer therapies.

Inhibitor of HMG-CoA reductase

Crassifolioside is a bioactive saponin-derived compound that is sourced from the Ligularia species, specifically Ligularia vellerea. This compound exhibits a distinct mode of action by interacting with specific cellular pathways to exert anti-inflammatory and antioxidant effects. It achieves this by modulating the activity of enzymes and signaling molecules involved in inflammation and oxidative stress responses. The uses and applications of Crassifolioside are predominantly in the field of medicinal chemistry and pharmacology, where it is investigated for its potential therapeutic benefits. It has garnered attention for its role in attenuating inflammatory processes and protecting cells from oxidative damage. This makes it a candidate for research into treatments for inflammatory diseases and conditions characterized by oxidative stress. Despite its promising bioactivity, further studies are essential to fully elucidate its mechanisms and to evaluate its efficacy and safety in clinical settings.