Deuterated Compounds

Applications 2-Butan-3,3,4,4,4-d5-ol was used to prepare and oxidize 3,3-disubstituted cyclobutenes. References Curry, M., et al.: J. Chem. Soc., 10, 1391 (1980)

Applications 1-Bromoheptane-5,5,6,6,7,7,7-d7 (CAS# 1219802-55-7) is a useful isotopically labeled research compound.

Applications Diphenyl Methyl Phosphate-d3 is the deuterated form of Diphenyl Methyl Phosphate (D492423), which is a phosphorus flame retardant additive. References Stapleton, H. M., et al.: Environ. Sci. Technol., 46, 13432(2012)

1a,25-Dihydroxy vitamin D2 is a compound that exhibits various characteristics and applications. It is known for its bioavailability and water-soluble properties, making it easily absorbed by the body. This compound has been extensively studied in the field of research chemicals. One of the notable features of 1a,25-Dihydroxy vitamin D2 is its potential therapeutic effects on ganglioside GM2-related disorders. It has been shown to interact with GM2 activator proteins and fatty acids, which are involved in the metabolism of GM2 gangliosides. This interaction may have implications for the treatment of certain neurological conditions. Additionally, 1a,25-Dihydroxy vitamin D2 has been investigated for its role in modulating immune responses and inflammatory processes. Studies have suggested that this compound can inhibit the production of pro-inflammatory substances like prostaglandins, offering potential anti-inflammatory benefits. Moreover, 1a,25-Dihydroxy vitamin D

Applications cis-Apovincamine-d3 is labelled cis-Apovincamine (A729245) which is a vinca alkaloid and a chemical precursor of Vinpocetine (V332500), a derivative of Vincamine with vasodilating activity. Vasodilator (cerebral). References Han, et al.: J. Biol. Chem., 274, 22337 (1999), O’Donnell, et al.: Pharmacol. Biochem. Behav., 63, 185 (1999),

Applications 4-Bromo-2-(ethyl-d3)pyridine is an intermediate in the synthesis of Ethionamide-d3 (E890422), a labelled antibacterial (tuberculostatic) agent. References Banerjee, A., et al.: Science, 263, 227 (1994), Newton, G., et al.: J. Bacteriol., 178, 1990 (1996), Baulard, A., et al.: J. Biol. Chem., 275, 28326 (2000), Koledin, T., et al.: Arch. Microbiol., 178, 331 (2002), Cardoso, R., et al.: Antimicrob. Agents Chemother., 48, 3373 (2004),

Applications N-[5-[2-[[2-(5-Amino-1,3,4-thiadiazol-2-yl)ethyl]thio]ethyl]-1,3,4-thiadiazol-2-yl]-benzeneacetamide-d5 is labelled N-[5-[2-[[2-(5-Amino-1,3,4-thiadiazol-2-yl)ethyl]thio]ethyl]-1,3,4-thiadiazol-2-yl]-benzeneacetamide (A630445) which can be used to prepare bis(phenylacetamidothiadiazolyl)ethyl sulfide analogs as glutaminase inhibitors and antitumor agents. References Shukla, K., et al.: J. Med. Chem., 55, 10551 (2012)

Phthalic-D4-anhydride is a benzyl derivative that is used as a catalyst in polymerization reactions. It is usually used in the production of polyester fibers, where it provides cross-linking during the fiber formation process. Phthalic-D4-anhydride has been shown to catalyze the dehydration reaction between styrene and carboxylate ions, which leads to the synthesis of polystyrene. This compound has also been shown to be effective in the production of subcritical water gas shift reactions. The mechanism behind this reaction is thought to be due to its ability to act as a dehydrating agent by removing water from the reactants, which leads to an increase in the concentration of hydrogen and carbon dioxide molecules.br>br> br>

Applications D-Methionine-d3 is used for detection D- and L-enantiomers of methionine and [2H3]methionine in plasma by gas chromatography-mass spectrometry of methylated/N-acylated derivatives. References Hasegawa, H., et al.: J. Chromatogr. B: 823, 203 (2005);

Applications Iodoethane-1,1-d2 is a useful reagent in synthesis of 1,4-benzoquinones. References Foland, L., et al.: J. Am. Chem. Soc., 111, 975 (1989);

Applications 3-Butenyl-d2 Tosylate is a proposed intermediate for the synthesis of (5S,5’S)-Dihydroxy Lysinonorleucine-d4 (D452902), which is isotope labelled (5S,5’S)-Dihydroxy Lysinonorleucine, a collagen reducible crosslink agent. References Mizikova, I. et al.: FEBS J., 285, 3056 (2018);

Applications Ethyl Vinyllactate-13C2,d3 is an intermediate in synthesizing Vinclozolin-13C3,d3 (V314053), which is a labelled analogue of Vinclozolin (V314050). Vinclozolin is an agricultural fungicide. References Pappas, A.C., et al.: Pestic. Sci., 10, 239 (1979)

Applications Bromoethane-1,1,2,2-d4 (CAS# 25854-32-4) is a useful isotopically labeled research compound.

Applications Diethyl Cromoglycate-D5 is an intermediate used in the synthesis of Cromolyn-d5 Disodium Salt (C815002), which is a chromone complex which blocks mast cell degranulation. References Ashton, M.J., et al.: Toxicol. Appl. Pharmacol., 26, 319 (1973), Friday, G.A., et al.: Am. J. Ophthalmol., 95, 169 (1983)

Applications Labelled insecticidal, acaricidal, and fungicidal combinations of carboxamides and other pesticides. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Dugo, G., et al.: Food Chem., 16, 435 (2005), Caldas, E., et al.: Toxicology, 222, 132 (2006), Cabras, P., et al.: J. Agric. Food Chem., 45, 2244 (1997), Wilkinson, C., et al.: Regul. Toxicol. Pharmacol., 31, 30 (2000),

Applications Isotope labelled D-galactose (G155250), A C-4 epimer of Glucose (G595000) found in milk and sugar beets as well as being synthesized by the body. Potential use in oral therapy for nephrotic syndrome in focal and segmental glomerulosclerosis. References De Smet, E. et al.: Nephrol. Dial. Transplant., 24, 2938 (2009); Kivele, R. et al.: Carb. Pol., 85, 645 (2011);