Deuterated Compounds

p-Cresol-d8 is an imidazolines that has been used in the techniques of regime and cardiac monitoring. It has been shown to be injected into the body for monitoring regimes, such as cardiac profiles. p-Cresol-d8 can be quantified in vitro by liquid chromatography, which is a technique used to separate and identify organic molecules. This chemical may also be found in dietary protein sources such as milk, eggs, and fish. Studies have shown that p-cresol-d8 is present in polyaromatic hydrocarbons emitted from coal burning factories. A cross-over study on this chemical was performed on rats to determine if it affects the severity of heart disease.

Applications Regorafenib-d3 is the isotope labelled analog of Regorafenib (R143000); a compound that inhibits PDGFR tyrosine kinase with IC50=83nM and is useful for the treatment of inflammation. Also an anti-proliferative agent. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Leuner, C., et al.: Eur. J. Pharm. Biopharm., 50, 47 (2000)

Applications N-D readily exchanges in protic solvents. References Dong, X., et al.: Bioorg. Med. Chem., 16, 8151 (2008), Kotecha, J., et al.: Int. J. Pharm., 360, 96 (2008), Takenaka, S., et al.: J. Biosci. Bioeng., 107, 27 (2009),

Applications Trigonelline-D3 is an intermediate used in the synthesis of Trigonelline-d3 HCl (N-methyl-d3) (T794052), which is deuterium labelled Trigonelline HCl. Trigonelline HCl has utility in developing site-specific system that delivers drugs to the brain. It has also been suggested as a potential anti-Alzheimer disease agent. References Bodor, N., et al.: J. Med. Chem 26, 313 (1983); Makowska, J., et al.: J. Chromatogr. B 968, 101 (2014)

Aniline D5 is a metabolic probe used to study the activation of carcinogens. Aniline D5 inhibits the growth of cancer cells by binding to amines, which are present in epidermal growth factor and other growth factors. When an anhydrous sodium hydrogen bond forms between the amines and the aniline, it causes a frequency shift in the aromatic ring that leads to a change in its physical properties. This change can be detected using high-resolution NMR spectroscopy. The sensitivity of this technique has been improved by adding activated charcoal as a matrix effect.

Applications 2-​Methyl-​1-​propanol-d7 is the d7 labeled analogue of 2-​Methyl-​1-​propanol (I780075) which is a reagent used in organic reactions. It is used in the synthesis of new fluorinating reagents. It is also used in the lipase-catalyzed production of biodiesel as an energy source. References Middleton, W. et al.: J. Org. Chem., 04, 574 (1975); Nelson, L. et al.: J. Amer. Oil. Chem. Soc.,