Deuterated Compounds

Applications Verapamil-d3 Hydrochloride is the labeled analogue of Verapamil Hydrochloride (V125000), which is a calcium channel blocker, antihypertensive, antianginal, and antiarrhythmic (class IV). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Atlas, D, and Adler, M.: Proc. Natl. Acad. Sci. USA, 78, 1237 (1981); Janis, R., et al.: Adv. Drug. Res., 16, 309 (1987)

Applications Cuprous Cyanide-15N is an intermediate in the synthesis of Bictegravir-15N, d2 (B382096), which is the labeled version of Bictegravir, which is a novel, potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM. References Tsiang M. et al.: Antimicrob Agents Chemother. 2016 Nov 21;60(12):7086-7097;

Applications 5-Ethyl-3-[[(2R)-1-methyl-2-pyrrolidinyl]methyl]-1H-indole-d5 is an isotope labelled impurity of Eletriptan (E505000), a serotonin 5-HTIB/ID receptor agonist and an antimigraine agent. References Madasu, S. B., et al.: Beilstein. J. Org. Chem., 8, 1400 (2012); Willems, E., et al.: Arch. Pharmacol., 358, 212 (1998), Napier, C., et al.: Eur. J. Pharmacol., 368, 259 (1999), Goadsby, P.J., et al.: Neurology, 54, 156 (2000)

Applications 4-Bromotoluene-2,3,5,6-D4 is used in the synthesis of some deuteriated benzene derivatives like isotopically labelled ZD4054 used to support the development of drug metabolism and pharmokinetics program. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Bergin, J. A., et al.: Journal of Label. Compds Radiopharm., 50, 431 (2007); Renaud, R. N., et al.: Canadian J. Chem., 39, 21 (1961)

Applications (R)-3-(2-Chloro-4-nitro-1H-imidazol-1-yl)-2-(4-trifluoromethoxybenzyl-d2-oxy)propyl-3,3-d2 Benzoate is an intermediate used in the synthesis of (S)-PA 824-d4 (P122502), which is a labelled novel anti-tuberculosis drug. References Diacon, A.H. et al.: Antimicrob. Anents Chemother., 54, 3402 (2010); Dogra, M. et al.: Br. J. Pharmacol., 162, 226 (2010); Ginsberg, A.M. et al.: Antimicrob. Agents Chemother., 53, 3720 (2009);

Applications 2-Butanol-d3 has been used to examine the loss of water form metastable 2-butanol/Mn+ cations using mass spectrometry. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Schroder, D., Schwarz, H.: Int. J. Mass Spec., 231, 139 (2004)

Applications m-Toluidine-d9 (CAS# 352431-22-2) is a useful isotopically labeled research compound.

Applications Thiodiglycol-d8 is the isotope labelled analog of Thiodiglycol, an environmental contaminant and the main product of sulfur mustard hydrolysis. References Angerhofer, R.A., et al.: Int. J. Toxicol., 33, 393 (2014)

Applications 1,2,4-Trichlorobenzene-d3 (CAS# 2199-72-6) is a useful isotopically labeled research compound.

Applications 4-​(Dimethyloxidoamino)​butanoic Acid-d6 Hydrochloride is the labelled form of 4-​(Dimethyloxidoamino)​butanoic Acid (D447160). 4-​(Dimethyloxidoamino)​butanoic Acid is a metabolite of Lauramine Oxide (L178530), which is a frequently used amine oxide surfactant. It is strongly hydrophilic , and it forms normal micelles and normal liquid crystalline phases. References Kocherbitov, v., et al.: J. Molec. Struct.: Theochem., 808, 111 (2007); Kocherbitov, v., et al.: J. Phys. Chem. B., 110 (27), 13649 (2006); Turan, T.S., et al.: Xenobiotica, 11, 447 (1981)

Applications p-​Tolunitrile-d7 is an isotopic analog of p-​Tolunitrile (T536235), a reagent used in the preparation of 1H-Indazoles from imidates and nitrosobenzenes. References Wang, Q. et al.: Org. Lett., 18, 2102 (2016);

Applications 4-​(Dimethylamino)​benzoic-​2,​3,​5,​6-​d4 Acid is an intermediate in the synthesis of DMABA-d4 NHS Ester (D678402), which is a labelled DMABA NHS ester (D678400). DMABA NHS ester is a reagent that reacts with the primary amine group of PE lipids. DMABA NHS ester has been used in combination with DMABA NHS ester-d4, -d6, and -d10 to study relative changes in PE lipid abundance before and after radical oxidation. References Wester, H., et al.: Nucl. Med. Bio., 23, 365 (1996), Frees, D., et al.: Mol. Microbiol., 48, 1565 (2003), Michel, A., et al.: J. Bacteriol., 188, 5783 (2006), Voelker, T., et al.: Bioorg. Med. Chem., 17, 2047 (2009),

Applications (9β,10α)-4-Chloro-Androst-4-ene-3,17-dione-d4 is an isotope labelled impurity of Androstenedione (A637550), a Testosterone (T155000) precursor and metabolite with androgenic activity. References Walker, V.R., et al.: Anal. Biopchem., 234, 194 (1996); King, D.S., et al.: J. Am. Med. Assoc., 281, 2020 (1999)

Applications Labelled Malic Acid. The naturally occuring isomer is the L-form which has been found in apples and many other fruits and plants. Selective α-amino protecting reagent for amino acid derivatives. Versatile synthon for the preparation of chiral compounds including κ-opioid receptor agonists, 1α,25-dihydroxyvitamin D3 analogue, and phoslactomycin B. References Rindi, G., et al.: Biochem. J., 80, 214 (1961), Wolfgang, M., et al.: J. Biol. Chem., 281, 37265 (2006), Navarro, D., et al.: Metab. Brain Dis., 23, 115 (2008),