Antifungals

Difenoconazole, a broad-spectrum triazole fungicide, blocks ergosterol production, disrupting fungal cell membranes and causing cell death.

iKIX1 reactivates Pdr1 genes, reversing C. glabrata's azole antifungal resistance in vitro and in vivo.

Fungicide

Tetrahydroepiberberine, an isoquinoline alkaloid, has antifungal and selective inhibition against the PI-3 virus activities.

QST4 possessed antitubercular and antifungal activities with a MIC value of 6.25 μM in Mycobacterium tuberculosis Mycobacterium tuberculosis H37Rv.

Applications 3(2H)-Isoxazolone is a 3-hydroxyisoxazole with fungicidal activity. 3(2H)-Isoxazolone is an impurity of Cycloserine (C988800). References Takahi, Y.: San. Kenk. Nen., 25, 8 (1973);

Filastatin is a long-lasting inhibitor of Candida albicans filamentation, and has potent antifungal effect.

Anthelmintic; inhibitor of tubulin polymerization

Caspofungin is an echinocandin that belongs to the class of antifungal agents. It is used to treat Aspergillus and Candida infections. It works by inhibiting the synthesis of beta-(1,3)-D-glucan, an essential component of the cell wall of Aspergillus species and Candida species. Caspofungin acetate is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

21-Norrapamycin is a macrocyclic lactone antibiotic, which is derived from the bacterium Streptomyces hygroscopicus. Its chemical structure is closely related to that of rapamycin, a well-known immunosuppressant. The mode of action of 21-Norrapamycin involves the inhibition of the mechanistic target of rapamycin (mTOR) signaling pathway. By binding to the FK506-binding protein 12 (FKBP12), it forms a complex that then inhibits mTOR, a crucial regulator of cell growth, proliferation, and survival. This compound is pivotal in research focused on cellular and molecular biology, particularly in understanding processes related to cancer, aging, and metabolic disorders. Due to its ability to inhibit mTOR signaling, 21-Norrapamycin has been utilized in studies exploring novel therapeutic approaches for diseases where aberrant mTOR activity is implicated. It provides a valuable tool for dissecting the intricate pathways that govern cell metabolism and proliferation, offering insights that could lead to the development of new pharmacological interventions.

Antibacterial compound 2 is a potent antimicrobial agent effective against many human veterinary pathogens, inhibiting multi-drug resistant staphylococci,

FR194738 free base inhibits squalene epoxidase activity in HepG2 cell homogenates with an IC50 of 9.8 nM. 

Cynaroside (Luteolin 7-O-Glucoside) is a flavone, a flavonoid-like chemical compound. It has an anti-oxidant effect, inhibiting lipid and protein oxidation.

Filipin is a polyene macrolide antifungal agent with action on cholesterol in cell membranes and is used for histochemical staining and research on cholesterol metabolism.

Ravuconazole (ER-30346) is a potent triazole antifungal that potently inhibits a wide range of fungi.

Fluazinam: a pyridinamine fungicide, broad-spectrum, strongly inhibits S. sclerotiorum mycelial growth.