Antifungals

Applications Blasticidin S Hydrochloride is a fungicide and antibiotic produced by Streptomyces griseochromogenes. Potential inhibitor of protein synthesis in bacteria and eukaryotes. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Svidritskiy, E. et al.: Proc. Natl. Acad. Sci. U.S.A., 110, 12283 (2013); Izumi, M. et al.: Exp. Cell. Res., 197, 229 (1991);

Dipyrithione appears to have novel cytotoxicity and potent broad-spectrum antitumor activity

Itraconazole is an anti-fungal drug that inhibits the synthesis of ergosterol, a component of the fungal cell membrane. Itraconazole is in a class of antifungals called triazoles. The drug binds to ergosterol in the fungal cell membrane and prevents it from being inserted into the membrane. This decreases the permeability of the plasma membrane, causing leakage of cellular contents. Additionally, it has been shown to have a glucose-lowering effect in the treatment of acute leukaemia and may be used for research in aiding to diagnose hematopoietic stem cell or leukaemia. Itraconazole is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Lucimycin is an antibiotic, which is derived from the fermentation of specific Streptomyces bacterial strains. This compound exerts its antibacterial effects by binding to the 50S subunit of the bacterial ribosome, thereby inhibiting protein synthesis and effectively halting bacterial growth. Lucimycin is particularly effective against Gram-positive bacteria and some Gram-negative species, making it a valuable tool in both clinical and research settings. The primary applications of Lucimycin are in the treatment of various bacterial infections where conventional antibiotics may fail or serve as second-line treatments. In research laboratories, it is often used to study bacterial resistance mechanisms and the efficacy of novel antibacterial combinations. Its unique mode of action provides essential insights into ribosomal function and protein synthesis pathways, contributing to the broader understanding of microbial biochemistry and cellular biology. Due to its potent inhibitory effects and specific action, Lucimycin remains a critical component in the arsenal against multidrug-resistant bacterial strains.

Fluxapyroxad is a broad-spectrum fungicide that inhibits the succinate dehydrogenase (SQR) enzyme.

Lawsone, a red-orange dye, found in henna leaves and water hyacinth flowers, is also 2-hydroxy-1,4-naphthoquinone.

Applications Benzotriazol-1-ylacetic Acid is used as a reagent in the synthesis of benzotriazole imidazoline compounds which are used as metal corrosion inhibitors. Benzotriazol-1-ylacetic Acid is also a reagent in the synthesis of N-(benzo[1,2,3]triazol-1-yl)-N-((benzyl)acetamido)phenyl carboxamides which are used as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors. References Turlington, M., et al.: Bioorg, Med. Chem. Lett., 23, 6172 (2013); Chen, Y., et al.: Faming Zhuanli Shenqing. CN 103664902 A 20140326. Mar 26, 2014

beta-Amyrone (β-Amyron) has antifungal activity against Chikungunya virus replication with an EC50 of 86 uM.

Stability Hygroscopic Applications L-Ergothioneine is a natural molecule isolated from the rye ergot fungus and later identified in rat erythrocytes and liver and in numerous other animal tissues. Its antioxidizing properties may afford the compound therapeutic potential or it may be used as a food additive or in cosmetics. References Nakamura, T., et al.: Biol. Pharm. Bull., 31, 1580 (2008), Yang, J., et al.: Food Chem., 114, 898 (2009), Grigat, S., et al.: Drug Metab. Disposition, 37, 330 (2009),

Alexidine dihydrochloride: antifungal, antibiofilm, targets PTPMT1 for mitochondrial apoptosis, potential cancer treatment.

Trifloxystrobin is a fungicide against R. solani in sugar beets with EC50s: 23.0 μg/L for Daphnia neonates, 1.7 μg/L for embryos.

Chlorothalonil (DAC 2787): Broad-spectrum, efficient, low-toxicity fungicide for fruits, vegetables, rice, wheat, cotton.

Oxiconazole is an anti-fungal agent that is used for the treatment of various dermatophyte infections. It can be used to treat athlete’s foot, ringworm and jock itch. This drug inhibits ergosterol biosynthesis and acts to destabilize the fungal cytochrome enzyme P450 51. Additionally, this drug has shown to inhibit DNA synthesis and suppress concentrations of ATP. Oxiconazole nitrate is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Epoxiconazole (BAS-480F) is a 14-α demethylase inhibitor. It inhibits ergosterol synthesis and fungal cell wall formation.