Antifungals

Pramiconazole (R126638), an oral antifungal, treats dermatophyte and yeast infections in seborrheic dermatitis.

Robinetin (3,3',4',5',7-Pentahydroxyflavone) has antioxidant and antiradical activities, inhibits EYPC membrane lipid peroxidation and HbA glycosylation with

Oenothein B inhibits PAR-glycohydrolase with antioxidant, anti-inflammatory, antifungal, anti-HCV, and antitumor effects.

Methyl alpha-L-fucopyranoside inhibits rhizobial lectins & Trichoderma reesei coiling; blocks PLL3, LECB, BAMBL.

Chelator 1a has antifungal activity, inhibiting Aspergillus and Candida, and can be used to study fungal infections and cancer.

Anti-fungal; sterol demethylase inhibitor

Climbazole (BAY-e 6975) is a broad-spectrum imidazole antifungal agent with anti-dandruff benefits.

Applications Used in the synthesis of new 5-nitroimidazoles as potential antibacterial drugs via VNS procedure. References Cudmore, S., et al.: Clin. Microbiol. Rev., 17, 783 (2004), Upcroft, J., et al.: Antimicrob. Agents Chemother., 50, 344 (2006),

Ciclopirox is a broad-spectrum antifungal agent that is used to treat onychomycosis of fingernails and toenails in immunocomprised patients. Ciclopirox has been shown to work by binding to polyvalent metal cations such Al3+ and Fe3+. These cations interfere with cellular processes including mitochondrial electron transport and energy synthesis by inhibiting numerous enzymes, including cytochromes. Additionally, the plasma membrane of fungi appears to be altered by ciclopirox as well, leading to the disorder of internal structures. Ciclopirox olamine is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Applications (5E)-5-(3-Bromopropylidene)-5,11-dihydro-10H-dibenzo[a,d]cyclohepten-10-one is an intermediate in the synthesis of 10-Hydroxy (E)-Amitriptyline (D462790). (5E)-5-[3-(dimethylamino)propylidene]-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-ol is a metabolite of amitriptyline (A633350) which is a dibenzocycloheptadiene derivative and an antidepressant (1). Amitriptyline is also a TrkA and TrkB receptor agonist and exhibits neurotrophic and anti-inflammatory activities (2,3). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA).