Antifungals

1-Isomangostin hydrate, a natural product extracted from the Mangosteen vine, exhibits antifungal activity.

Butoconazole nitrate is an antifungal agent and is used for the treatment of vaginal yeast infections. It inhibits the synthesis of ergosterol, disrupting the fungal cell membrane.

Pafuramidine is an antiprotozoal prodrug with action on protozoal DNA synthesis inhibition and is used for treating African sleeping sickness and Pneumocystis pneumonia.

Sulbentine (Dibenzthione) is an antifungal agent.

Benodanil (Calirus) is a kind of fungicide.

Abafungin is an antifungal agent and is used for treating fungal infections.

Applications An isotopically Labelled metabolite of Itraconazole, an orally active antimycotic structurally related to Ketoconazole. It is a COVID19-related research product. References Saag, M., et al.: Antimicrob. Agents Chemother., 32, 1 (1988), Haria, M., et al.: Drugs, 51, 585 (1996), Kousoulos, C., et al.: Anal. Bioanal. Chem., 384,199 (2006),

Triclopyr (NSC 190671) is a synthetic growth hormone-like herbicide and fungicide with cytotoxicity and mitochondrial damage induced in rat liver

Applications Deoxo Anhydro Itraconazole Bromide is an impurity of Itraconazole (I937500), which is orally active antimycotic drug structurally related to Ketoconazole (K186000). Antifungal. It is a COVID19-related research product. References Espinel-Ingroff, A., et al.: Antimicrob. Agents Chemother., 26, 5 (1984); Heykants, J., et al.: Mycoses, 32, Suppl 1, 67 (1989); Sugar, A.M.,et al.: Curr. Clin. Top. Infect. Dis., 13, 74 (1993);

Fengycin A analogue is an antifungal lipopeptide, which is a cyclic compound derived from microbial sources, specifically produced by Bacillus subtilis strains. It functions primarily by disrupting the cell membranes of pathogenic fungi, leading to altered membrane permeability and subsequent cell death. The unique structure of fengycin allows it to interact with membrane lipids, compromising membrane integrity and inhibiting fungal growth. The uses and applications of Fengycin A analogue are notable in agricultural settings, where it serves as a biocontrol agent against various fungal pathogens affecting crops. Its role extends to contributing to sustainable agricultural practices by reducing the need for chemical fungicides. Additionally, it is of interest in pharmaceutical research due to its potential therapeutic applications against fungal infections. The compound's specific mode of action and natural origin make it a promising candidate for further investigation in both the development of novel antifungal strategies and the enhancement of plant health.

Eberconazole Nitrate (Ebernet) is an azole antifungal agent and broad-spectrum imidazole derivative.

Kanosamine (3-Amino-3-deoxyglucose) is an antifungal agent produced by a Streptomyces sp.

Phenylethyl isothiocyanate (JC5411) is an HDAC inhibitor. It potentially for the treatment of benign prostatic hypertrophy.

Picropodophyllone is one of the lignans from the roots of D. aurantiocaulis and D. pleianthum.