Antivirals

Applications A deuterated, potent and selective inhibitor of HIV-1 replication. References Mitsuya, H., et al.: Nature, 325, 773 (1987), Brehm, J., et al.: Biochem., 47, 14020 (2008), Paredes, R., et al.: J. Virol., 83, 2038 (2009), Wan, J., et al.: J. Med. Chem., 52, 1144 (2009), Mainardes, R., et al.: J. Pharm. Sci., 98, 257 (2009),

ITMN4077 is an antiviral that inhibits Hepatitis C replication in HuH7 cells, with an EC50 of 2.131μM.

Applications Daclatasvir Dihydrochloride is an anti-hepatitis C drug. References Song, B., et. al.: Zhongguo Xinyao Zazhi, 22, 2679 (2013); Gao, M., et al.: Nature, 465(7294), 96 (2010); Bell, T. W., Chem. Med. Chem., 5(10), 1663 (2010);

IM-250 possesses antiviral activity with IC values of 25 nM - 100 nM.

Impurity Tenofovir Disoproxil USP Related Compound A Applications The S-enantiomeric impurity of the antiviral Tenofovir Disoproxil Fumarate (T018505(P)), which is an acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor and used as an anti-HIV agent.Tenofovir Disoproxil USP Related Compound A. References Shaw, J. P., et al.: Pharm. Res., 14, 1824 (1997), Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007)

Applications Elenolic Acid is an antiviral agent that inhibits reverse transcriptases, inhibited the growth of chicken embryo fibroblast cells as well as Escherichia coli and Bacillus subtilis strains. References Heinze, J.E., et al.: Antimicrob. Agents Chemother., 8, 421 (1975); Renis, H,E..: Antimicrob. Agents Chemother., 8, 149 (1975)

Balapiravir is an antiviral agent, which is a synthetic derivative based on natural compounds, specifically designed to inhibit the replication of various viral pathogens. The source of Balapiravir integrates bio-based elements with modifications to enhance its therapeutic efficacy. The mode of action of Balapiravir involves its interference with the viral RNA polymerase enzyme, effectively halting the synthesis of viral RNA. This mechanism prevents the proliferation of the virus within the host cells, thereby reducing viral load and ameliorating disease symptoms. Balapiravir finds its applications in the treatment of viral infections such as influenza and certain emerging viral diseases. It is particularly significant in managing outbreaks due to its broad-spectrum activity. Research is ongoing to expand its application to include various other viral strains, enhancing its utility and adaptability across different viral challenges. The focus on Balapiravir underscores its potential as a strategic tool in antiviral therapy, contributing significantly to the clinical management and prevention of viral pathogenicity.

Applications Labelled Nevirapine (N391275), a potent (IC50=84nM) and selective non-nucleoside inhibitor of HIV-1 reverse transcriptase. Antiviral. References Hargrave, K.D., et al.: J. Med. Chem., 34, 2231 (1991), Cheeseman, S.H., et al.: Antimicrob. Agents Chemother., 37, 178 (1993), Guay, L.A., et al.: Lancet, 354, 795 (1999),

Anti-viral; NS5A protein inhibitor

Applications Labelled Dapivirine (D185500). Non-nucleoside Reverse Transcriptase inhibitor. An antiviral agent. References Qin, B., et al.: J. Med. Chem., 53, 4906 (2010), Woolfson, A., et al.: Int. J. Pharm., 388, 136 (2010), Johnson, T., et al.: Eur. J. Pharm. Sci., 39, 203 (2010),