Antivirals

Raltegravir is an antiretroviral agent that is used for the treatment of HIV infections. It inhibits HIV integrase in order to prevent viral genome from being inserted into the human genome. It binds to the active site of the enzyme and prevents it from binding to a target sequence on the viral DNA. This drug is metabolized by glucuronidation. Raltegravir potassium is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Calcitriol Impurities D: Vitamin hormone, promotes cell differentiation, has bone activity, inhibits HIV, and aids in treating AIDS/viral infections.

Ganciclovir is an antiviral agent specifically designed for culture media use. It is a synthetic analogue of 2'-deoxy-guanosine, derived from nucleoside compounds, and operates primarily by inhibiting the replication of viral DNA. Its mode of action involves selective phosphorylation by viral kinases, which converts it into ganciclovir triphosphate, a potent inhibitor of viral DNA polymerase, ultimately preventing viral DNA synthesis. In scientific settings, Ganciclovir is frequently employed in the selective inhibition of viral replication within culture media, allowing for precise studies of cellular or viral interactions without interference from unwanted viral proliferation. Its specificity makes it an invaluable tool for virologists and molecular biologists conducting research in environments where control of viral replication is crucial. The precision in its application assists in obtaining clear, unconfounded results, particularly in studies related to viral pathogenesis and the development of antiviral therapies.

Equisetin is a secondary metabolite, which is produced by the fungus *Fusarium equiseti*. It operates predominantly through the inhibition of protein synthesis and interference with cellular processes within target organisms. Equisetin exhibits potent antibacterial and antifungal activities primarily by interfering with cell wall synthesis in bacteria and disrupting key pathways in fungi. The applications of Equisetin are chiefly in the fields of pharmaceutical research and agricultural science. In pharmaceutical research, it serves as a template for developing new antibiotics due to its unique mode of action and effectiveness against resistant microbial strains. In the realm of agriculture, Equisetin is investigated for its potential as a biocontrol agent to protect crops from pathogenic fungi and bacteria, thereby reducing reliance on synthetic chemical pesticides. The exploration of Equisetin’s structure and activity also provides valuable insights into natural product biosynthesis and potential novel therapeutic pathways.

Applications 3-(3-Azido-2,3-dideoxy-β-D-erythro-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione is an impurity of Zidovudine (A825000). Zidovudine is an antiviral agent used in the clinical treatment of HIV infections. References Radatus, B.K., Org. Process. Res. Dev., 15, 1281 (2011)

Applications Oseltamivir (O701000) impurity. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Muller, N., et al.: J. Phys. Chem., 83, 1393 (1979), Katritzky, A., et al.: Chem. Rev., 104, 175 (2004),