Antiparasitics

Applications The major product of the stereoselective human metabolism of Chloroquine, used for the therapy and prevention of malaria. It is a COVID19-related research product. References Essien, E., et al.: J. Pharm. Pharmacol., 38, 543 (1986), Akintonwa, A., et al.: Ther. Drug Monit., 10, 147 (1988), Boelaert, J., et al.: AIDS, 15, 2205 (2001), Basco, L., et al.: Antimicrob. Agents Chemother., 47, 1391 (2003),

4′-O-De(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-5-O-demethylavermectin A1a is a semi-synthetic derivative of avermectin, which is a naturally occurring compound isolated from the fermentation broth of the soil bacterium *Streptomyces avermitilis*. This compound exhibits potent antiparasitic activity by targeting the glutamate-gated chloride channels in the nervous systems of parasitic organisms. By binding and activating these channels, it increases the permeability of the cell membrane to chloride ions, resulting in paralysis and death of the parasite. The compound is primarily used to control a variety of parasitic worms and arthropods in both agricultural and veterinary contexts. Its specificity for invertebrate nerve cells over those of vertebrates makes it particularly effective with minimal toxicity to the host species. This precision in action helps maintain ecological balance while preserving host health. It is a critical tool in managing parasitic resistance, providing a reliable option for controlling infestations that are prone to adapt to other treatment strategies.

Antiparasitic Agent-20 (Compound 1p) exhibits broad-spectrum activity as a parasitic inhibitor, demonstrating efficacy against T.

Robenidine hydrochloride (Robenidine Hydrochoride) is an anticoccidial agent mainly used in poultry.

Decoquinate (Deccox) is a coccidiostat for poultry.

Antitrypanosomal agent 12, a C20-phenylthiourea, exhibits trypanocidal and cytotoxic activities, demonstrating antitrypanosomal activity with GI50 values of 0.

Compound 42 (Compound 2), an antimalarial agent, effectively inhibits Plasmodium falciparum during the asexual blood stages (IC 50 <0.5μM) and gametocytes (IC 50 is 0.14 μM).

Sulfadoxine (Sulphadoxine) is a broad-spectrum sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with bacteriostatic and antimalarial

Ferrocene, a crucial structural core in bioorganometallic chemistry, is renowned for its intrinsic stability, excellent oxygen reduction capabilities, and low toxicity. It also exhibits antimalarial and anticancer properties.

Ronidazole (Ronidazol) is an antiprotozoal and antimicrobial agent used mainly in veterinary practice.

Eprinomectin (MK-397) is an avermectin with anthelmintic and insecticidal activities.

Piperaquine tetraphosphate tetrahydrate is a potent anti-parasites agent.

BPH-715 inhibits the liver-stage growth of P. falciparum with an IC50 of 10 μM for P. falciparum exoerythrocytic forms in HepG2 cells.

Antitrypanosomal agent 14 (Compound 1), a potent T.

Halofuginone specifically inhibits collagen type I and MMP-2 gene expression, which may result in the suppression of angiogenesis and tumor cell growth.