Antiparasitics

MMV688533 has antimalarial activity.

Applications Hydroxychloroquine Dimer is an impurity of the drug Hydroxychloroquine (H916900), an antimalarial; antirheumatic; lupus erythematosus suppressant. It is a COVID19-related research product. References Yarden, Y., et al.: Nature, 323, 226 (1986); Seifert, R., et al.: J. Biol. Chem., 264, 8771 (1989); Gahl, W., et al.: Mol. Genet. Metab., 76, 234 (2002); Card, J., et al.: Toxicol. Sci., 75, 169 (2003)

Isopimpinellin (4,9-Dimethoxypsoralen) is a natural product isolated from the roots of Pimpinella saxifrage with antiviral and antileishmanial activity.

Insecticidal agent 2 (example 2) is an effective pesticide that significantly inhibits pest growth [1].

NEU-1017 serves as a broad-spectrum antiparasitic compound, effectively inhibiting T. brucei, L. major, and P. falciparum with EC50 values of 210 nM, 240 nM, and 3 nM, respectively.

Niridazole (Ambilhar) is an antiparasitic compound belonging to nitroimidazoles.

Thiabendazole is a benzimidazole anthelmintic with action on parasitic worms by inhibiting energy metabolism and is used for treating infections like threadworm and roundworm.

Hexythiazox is a mite growth regulator and a thiazolidine based acaricide that has long-lasting effects against many kinds of mites and is applied at any stage

Stability Moisture Sensitive Applications N-(2-Benzoyl-4-chlorophenyl)formamide is used as a reagent in the synthesis of 2-aminoindole compounds that can be used as antimalarial agents. References Mazitschek, R., et al.: PCT Int. Appl. WO 2011053697 A1 20110505. May 5, 2011

Selamectin (UK-124114) is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in

Oxantel Pamoate (Oxantel embonate) is used as an Antinematodal agent.

Applications trans-4-(4-Chlorophenyl)cyclohexanecarboxylic Acid is an impurity of Atovaquone (A793500), which is a hydroxynaphthoquinone derivative that inhibits mitochondrial electron transport and possess antipneumocystic activity. References Hudson, A.T., et al.: Drugs Exp. Clin. Res., 17, 427 (1991), Fry, M., et al.: Biochem. Pharmacol., 43, 1545 (1992), El-Sadr, W.M., et al.: N. Engl. J. Med., 339, 1889 (1998),

Pyrantel pamoate (Pyrantel embonate) is a depolarizing neuromuscular blocking agent.

Naturally produced by the soil bacterium Streptomyces avermitili, Ivermectin is clinically used in the treatment of parasitosis in both humans and animals. Ivermectin is commercially available as a mixture of 80% 22, 23-dihydroavermectin B1a and 20% 22, 23-dihydroavermectin B1b. In 2020, research indicated that it was a good antiviral agent in the treatment of SARS-CoV-2 and a new mechanism of action has been suggested. Ivermectin would act on importin α/β heterodimer and affect nuclear transport and the translocation of viral proteins. Ivermectin is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.