Flavonoids

7,8-Dihydroxyisoflavone is an isoflavone compound, which is a naturally derived product found predominantly in plants like Trifolium pratense, also known as red clover. It is classified as a selective tyrosine receptor kinase B (TrkB) agonist, which means it can mimic the action of brain-derived neurotrophic factor (BDNF), a protein crucial for neuronal survival, growth, and differentiation in the central nervous system. The mode of action involves binding to the TrkB receptor, leading to autophosphorylation and activation of downstream signaling pathways, such as the PI3K/Akt and MAPK/ERK pathways. These pathways promote cell survival and neuroprotection, making 7,8-Dihydroxyisoflavone a compound of interest in neurology research. This compound is being studied for its potential therapeutic applications in neurodegenerative diseases like Alzheimer's, Parkinson's, and Huntington's disease, due to its ability to cross the blood-brain barrier and exert effects that may improve cognitive functions and inhibit neuronal apoptosis. Its involvement in mood regulation suggests potential use in treating depression and anxiety. Researchers are investigating its pharmacokinetics and safety profile to advance understanding and application in clinical settings.

Natural glycoside

Euchrestaflavanone B is a naturally occurring flavonoid, which is a type of polyphenolic compound. It is primarily sourced from various plant species, particularly those found in the Leguminosae family. The mode of action of Euchrestaflavanone B involves its interaction with cellular signaling pathways, where it exhibits a broad spectrum of bioactive effects. These include anti-inflammatory, antioxidant, and anticancer properties, potentially through modulation of enzyme activities and gene expression. In terms of applications, Euchrestaflavanone B is of significant interest in research related to pharmacology and nutraceuticals. Its ability to mitigate oxidative stress and modulate immune responses makes it a promising candidate for developing therapeutic agents aimed at treating chronic inflammatory diseases and cancer. Furthermore, due to its natural origin and bioactivity, Euchrestaflavanone B also attracts attention for use in dietary supplements and functional foods. However, while its potential is substantial, comprehensive clinical studies are necessary to fully understand its mechanisms and efficacy in human applications.

(E)-Deschlorophenyl fluoxastrobin is a synthetic fungicide, which is derived from the strobilurin class of compounds, originally sourced from natural fungal metabolites. It functions by inhibiting mitochondrial respiration in fungal cells through disruption of the cytochrome bc1 complex, specifically at the Qo site. This mode of action effectively curtails the energy supply of the pathogen, leading to its death, and is integral in managing resistance issues known to occur with other fungicide groups. The primary applications of (E)-Deschlorophenyl fluoxastrobin include its use in agriculture for protection against a wide range of fungal diseases affecting crops such as cereals, fruits, and vegetables. Its formulation is designed to provide both protective and curative effects, making it versatile in disease management protocols. Additionally, the compound offers systemic activity, allowing it to penetrate plant tissues and provide long-lasting protection even under adverse environmental conditions. The compound's unique properties and efficacy contribute significantly to improving yield and crop quality, thereby supporting sustainable agricultural practices.

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Swertiajaponin is a natural bioactive compound, classified as a flavonoid glycoside, which is derived from the plant Swertia japonica. Swertia japonica, a member of the Gentianaceae family, is predominantly found in East Asia, where it has been traditionally used in herbal medicine. As with many bioactive compounds, swertiajaponin exhibits its pharmacological effects through various biochemical interactions, including antioxidant, anti-inflammatory, and hepatoprotective activities. It is known to modulate cellular pathways and free radical scavenging, contributing to its therapeutic potential. The uses and applications of swertiajaponin are diverse, with research indicating its efficacy in protecting against liver damage, supporting wound healing, and exhibiting anti-cancer properties. It is also being studied for its potential benefits in managing diabetes and cardiovascular diseases due to its ability to regulate multiple metabolic pathways. Given its diverse range of effects, swertiajaponin represents a promising candidate for further pharmacological and clinical studies aimed at developing new therapeutic strategies.

6,7,3',4'-Tetrahydroxyflavone is a natural flavonoid compound, which is a class of polyphenolic molecules found ubiquitously in plants. These compounds are synthesized via the phenylpropanoid pathway, predominantly in the leaves, flowers, and fruits of plants. 6,7,3',4'-Tetrahydroxyflavone exhibits its effects primarily through antioxidant and anti-inflammatory mechanisms. It interacts with cellular pathways to scavenge free radicals and modulate signaling pathways involved in inflammation and oxidative stress. The compound’s modes of action include the inhibition of enzyme activities, such as cyclooxygenases, and modulation of gene expression related to pro-inflammatory mediators. These properties make it a subject of interest for research into its potential therapeutic applications in chronic diseases, such as cardiovascular diseases, neurodegenerative disorders, and certain types of cancer. It has been studied for its ability to protect cells from oxidative damage and to ameliorate inflammation-mediated tissue damage. As scientific investigations continue, this flavonoid holds promise for the development of novel therapeutic strategies.

3,2',4',5'-Tetra methoxyflavone is a specialized flavonoid compound, which is derived primarily from various plant sources, such as those belonging to the genus Kaempferia, a member of the ginger family. This compound is characterized by its four methoxy groups attached to its flavonoid backbone, which significantly influences its biological activity and solubility. Mode of action involves modulation of key signaling pathways related to inflammation and oxidative stress. The compound exerts its effects by inhibiting pro-inflammatory cytokines and enzymes, and enhancing the activity of cellular antioxidant systems. This dual action results in reduced cellular damage and inflammation, making it a target for therapeutic development. Applications of 3,2',4',5'-Tetra methoxyflavone include its use in research focused on the management of chronic inflammatory conditions and oxidative stress-related disorders. It serves as a biochemical tool in the exploration of flavonoid activity on molecular signaling pathways. The compound's role in modulating inflammation also presents potential for exploration in nutraceutical formulations aimed at improving health outcomes associated with inflammatory processes.

7,3'-Dimethoxyflavone is a flavonoid compound, which is a type of secondary metabolite found in various plants. This compound is primarily sourced from the leaves and stems of certain plant species, where it acts as a natural protector against pathogens and contributes to the plant's development and survival mechanisms. Flavonoids like 7,3'-Dimethoxyflavone exert their biological effects through several modes of action, including antioxidant activity, modulation of enzyme function, and interaction with cell signaling pathways. They are known to scavenge free radicals and reduce oxidative stress, thereby protecting biological systems from damage. Research into 7,3'-Dimethoxyflavone has highlighted its potential use in therapeutic applications. It is studied for its neuroprotective properties, as well as its ability to influence various cellular processes that may ameliorate conditions such as inflammation and certain neurodegenerative diseases. Additionally, the compound's potential to act as a chemopreventive agent underscores its relevance in ongoing pharmacological studies.

Applications 5α-Pregnane-3-one-20α-ol, is a steroid metabolome, that can be used for in studies of a possible tool for laboratory diagnosis of schizophrenia. It is also a metabolite of Progesterone (P755900) in adipose cells. References Bicikova, M., et al.: J. Steriod Biochem. Mol. Bio., 77, 133 (2013); Zhang, Y., et al.: Mol. Cell. Endocrinology, 298, 76 (2009);

Natural glycoside

Puerarin analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Natural glycoside