Flavonoids

Isorhamnetin-3-O-rutinoside analytical standard provided with w/w absolute assay, to be used for quantitative titration.

(S)-Hesperetin is a flavonoid compound, which is a naturally occurring polyphenolic structure. It is predominantly derived from citrus fruits, including oranges and lemons, through the metabolic breakdown of its glycoside form, hesperidin. This transformation occurs in the human body, where hesperidin is hydrolyzed to release hesperetin and other metabolites. The mode of action of (S)-Hesperetin involves its ability to modulate various biological pathways. It exhibits potent antioxidant activity by scavenging free radicals and chelating metal ions, which helps in reducing oxidative stress at the cellular level. Additionally, it interacts with signaling cascades to exert anti-inflammatory effects, and has been observed to influence lipid metabolism and modulate enzyme activities related to detoxification processes. (S)-Hesperetin is used in research focused on chronic diseases where oxidative stress plays a role, such as cardiovascular disease, neurodegenerative disorders, and cancer. Its potential applications extend to the development of functional foods and nutraceuticals aimed at enhancing human health by leveraging its antioxidant and anti-inflammatory properties. Scientists are particularly interested in exploring its bioavailability and metabolic pathways to better harness its therapeutic potential.

Oxygen-heterocyclic compound

5,2'-Dimethoxyflavone is a synthetic or naturally occurring flavone, which is derived from certain plants. It belongs to the class of polyphenolic compounds found predominantly in the plant kingdom. As a secondary metabolite, this compound is linked to the plant's defense mechanisms, typically sourced from herbs known for their therapeutic potential. The mode of action of 5,2'-Dimethoxyflavone involves various biological pathways. It is hypothesized to interact with signaling pathways and receptors, potentially influencing anti-inflammatory, antioxidant, and neuroprotective responses. The precise biochemical interactions remain an ongoing area of research, with studies indicating its ability to modulate enzyme activity and gene expression. Applications of 5,2'-Dimethoxyflavone are primarily concentrated within the pharmacological and biochemical research domains. It is explored for its potential therapeutic benefits against a range of conditions, such as oxidative stress-related disorders, inflammation, and neurodegenerative diseases. Researchers utilize this compound as a model to elucidate underlying biological processes and assess the possibility of developing novel therapeutic agents. The continued study of 5,2'-Dimethoxyflavone is significant for advancing our understanding of flavonoids in medicinal chemistry.

4',5,7-Trihydroxyisoflavone is used to inhibitor of tyrosine protein kinase. Genistein inhibits EGF-stimulated phosphorylation in cultured cells. Also used to explore signal transduction pathways. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

7,2'-Dibenzyloxy-4'-methoxyisoflavone is a synthetic isoflavone compound, which is derived from chemical synthesis processes rather than natural sources. Isoflavones are a class of flavonoids often studied for their diverse biological activities, including antioxidant, anti-inflammatory, and potential anticancer properties. This compound is characterized by its unique chemical structure that incorporates benzyl and methoxy groups, possibly enhancing its pharmacokinetic profile and efficacy. The mode of action for 7,2'-Dibenzyloxy-4'-methoxyisoflavone may involve modulation of cellular signaling pathways and enzyme inhibition, although specific mechanisms require further elucidation. Its interactions at the molecular level could affect various biological processes, warranting detailed pharmacological studies. Applications of this compound can span a range of scientific research fields, including pharmacology, biochemistry, and molecular biology. Researchers might explore its potential as a lead compound in drug development, focusing on its ability to target specific biological pathways pertinent to disease states. Effective utilization in experimental setups could provide insights into novel therapeutic strategies and deepen understanding of isoflavone-related bioactivities.

Hinokiflavone-7,7”,4”’-trimethyl ether is a specialized biflavonoid compound, which is a type of plant secondary metabolite. Derived primarily from certain species of the Cupressaceae family, it showcases the diverse capabilities of flavonoids in biochemical pathways. This compound functions by modulating enzyme activities, interacting with cellular receptors, and exhibiting antioxidant properties. It acts through mechanisms involving inhibition of specific kinases and other enzymes, thereby influencing cell signaling pathways and inflammatory responses. The primary uses and applications of hinokiflavone-7,7”,4”’-trimethyl ether are found in the realm of pharmacological research. Scientists are investigating its potential roles in mitigating oxidative stress and its anti-inflammatory effects, which could translate into therapeutic strategies for chronic diseases such as cancer and arthritis. Its mode of action and source specificity also makes it an intriguing candidate for studying plant biochemistry and interspecies interactions within ecological settings. The ongoing research aims to unravel further its molecular interactions and validate its efficacy and safety in clinical scenarios.

AntioxidantImage created by Dave Richardson sourced from https://www.inaturalist.org/photos/171407970

4',5,7-Trihydroxyflavone is a nonmutagenic flavonoid shown to inhibit cell proliferation, angiogenesis and protein kinase. Also induces apoptosis in breast cancer cells. It inhibit topoisomerase I-catalyzed DNA re-ligation and enhance gap junctional intercellular communication. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

3,7,3',4',5'-Pentamethoxyflavone is a polymethoxyflavone, which is a class of flavonoids characterized by multiple methoxy groups. It is predominantly found in certain citrus fruits, particularly in the peels. The compound is isolated through extraction and purification processes that leverage the natural abundance in these sources. With respect to its mode of action, 3,7,3',4',5'-Pentamethoxyflavone interacts with various cellular pathways. It demonstrates potential bioactive properties, including modulation of enzyme activity and anti-inflammatory effects, largely through its interaction with cellular signaling pathways. This action contributes to the regulation of immune responses and may affect oxidative stress mechanisms. Applications of 3,7,3',4',5'-Pentamethoxyflavone are currently a subject of extensive research. Scientists are exploring its potential in pharmacological contexts, particularly in anti-inflammatory and antioxidant therapies. Its ability to influence biological pathways underscores its potential role in developing new therapeutic agents. Further investigations are warranted to elucidate its full spectrum of biological activities and to assess its efficacy and safety in clinical applications.

Retusin is an alkaloid compound, which is derived from organic botanical sources, specifically certain plant species known for their medicinal properties. It functions primarily through a bactericidal mode of action by interfering with bacterial cell wall synthesis and disrupting critical metabolic pathways essential for bacterial survival. This interference effectively inhibits bacterial growth and proliferation, leading to cell death. Retusin is utilized in various biomedical applications, primarily as a therapeutic agent targeting bacterial infections resistant to standard antibiotics. It is of particular interest in the development of new antimicrobial agents, offering a novel mechanism of action that may circumvent common resistance pathways seen in traditional drugs. Researchers are also exploring its potential synergistic effects when used in combination with other antimicrobial therapies. Through rigorous laboratory studies, Retusin holds promise as a key component in addressing the global challenge of antibiotic resistance, pushing forward the boundaries of contemporary microbial pharmacology.

Rhamnetin-3-rutinoside is a specialized bioflavonoid, a type of plant-derived polyphenolic compound. It is typically sourced from various plant species, where it naturally occurs as part of the plant’s secondary metabolites. This compound functions primarily as an antioxidant, where its mode of action involves scavenging free radicals and stabilizing reactive oxygen species, thereby protecting cells from oxidative stress. In scientific research, Rhamnetin-3-rutinoside is studied for its potential protective effects against various diseases caused by oxidative damage, including certain cancers, cardiovascular diseases, and neurodegenerative disorders. Its application extends to the exploration of its therapeutic potential, possibly contributing to the development of pharmaceuticals or functional foods aimed at enhancing health through its antioxidative properties. Research continues to delve into its efficacy, bioavailability, and mechanisms of action within biological systems.