Flavonoids

Kaempferol 3-O-(6''-galloyl)-beta-D-glucopyranoside is a glucopyranoside that inhibits HIV-2 RNase H with an IC50 of 5.19 μM.

Theaflavin-3,3'-digallate is a polyphenolic compound, which is primarily derived from black tea through the oxidative fermentation of tea leaves. This compound is part of the theaflavins, which result from the enzymatic oxidation of catechins, the major constituents of green tea. It exhibits various biological activities due to its complex molecular structure, which includes multiple hydroxyl groups that facilitate specific intermolecular interactions. The mode of action of Theaflavin-3,3'-digallate is largely attributed to its ability to modulate cellular signaling pathways. It acts as a potent antioxidant by scavenging reactive oxygen species, thus reducing oxidative stress. Additionally, it has been shown to influence pathways involved in apoptosis and cell cycle regulation, making it a compound of interest in oncological studies. Theaflavin-3,3'-digallate has applications in the biomedical field, particularly in cancer research, due to its potential to inhibit tumor growth. Its antioxidant properties are also under investigation for the prevention of chronic diseases associated with oxidative damage, including cardiovascular diseases. Researchers focus on elucidating its precise mechanisms and potential therapeutic roles, aiming to harness its benefits for health applications.

5,8-Dihydroxy-3,3',4',7-tetramethoxyflavone is a secondary metabolite of plants that belongs to the group of phytochemicals. It is one of the most potent natural antioxidants and has been shown to have antioxidant activity in a number of different assays. 5,8-Dihydroxy-3,3',4',7-tetramethoxyflavone can be used for analytical purposes as an HPLC standard or reference material. This compound has also been shown to inhibit tumor cell proliferation in vitro and may be useful for research and development purposes.

Geraldol analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Oxygen-heterocyclic compound

Pratensein is an isoflavone compound that is derived primarily from plants such as red clover (Trifolium pratense). This natural product belongs to the class of phytochemicals known for their diverse biological activities. Pratensein is sourced through the extraction and purification processes that involve isolating the bioactive components from plant materials rich in flavonoids. The mode of action of Pratensein involves its ability to interact with biological pathways as an antioxidant. It functions by scavenging free radicals and mitigating oxidative stress within the cell, thus providing a protective mechanism against cellular damage. Pratensein’s structural properties allow it to incorporate within lipid bilayers, enhancing its efficacy in biological systems. Scientifically, Pratensein finds applications as a research focus in exploring therapeutic roles, particularly in studying its potential effects on inflammatory pathways and its contribution to the modulation of hormone-dependent processes. Its role in preclinical studies emphasizes its potential in contributing to the development of interventions for oxidative stress-related conditions, making it a compound of significant interest in the field of medicinal chemistry and pharmacology.

6-Hydroxy-5,7,4'-trimethoxyflavone is a methoxylated flavone, which is a type of polyphenolic compound. It is derived from various natural sources, including certain plant species where flavonoids are abundant. This compound features distinct methoxy and hydroxyl groups that contribute to its biochemical activity. The mode of action of 6-Hydroxy-5,7,4'-trimethoxyflavone involves interacting with molecular pathways related to oxidative stress and inflammation. Its structure allows for antioxidant activity, potentially neutralizing free radicals and reducing cellular damage. Additionally, it may play a role in modulating enzymatic pathways, influencing various biological responses. The applications of 6-Hydroxy-5,7,4'-trimethoxyflavone are quite varied, particularly in biomedical research. It is investigated for its potential therapeutic effects, including anti-cancer, anti-inflammatory, and neuroprotective properties. Studies explore its utility in developing novel pharmaceuticals and as a model compound for understanding the effects of methoxylated flavones in biological systems. Continued research is essential to fully elucidate its capabilities and potential clinical applications.

6-O-Acetyldaidzin is a chemical compound that serves as an isoflavone derivative, primarily obtained from the acetylation of daidzin. This compound is a naturally occurring glycoside found in soy products and other leguminous plants, acting as a bioactive constituent with diverse pharmacological properties. The mode of action of 6-O-Acetyldaidzin involves its metabolic conversion into daidzein within the human body. Daidzein is known to interact with estrogen receptors and exhibit antioxidant activities. Such interactions contribute to its potential role in hormone regulation and cellular protection against oxidative stress. In terms of applications, 6-O-Acetyldaidzin is explored in scientific research assessing its effects on health, particularly in the context of cancer prevention, cardiovascular health, and bone density. Its role in modulating estrogenic activity makes it a candidate for studies on menopausal symptoms. Furthermore, its antioxidant properties entail potential uses in combating cellular aging and inflammatory-related conditions. Studies are ongoing to fully elucidate its biological functions and therapeutic possibilities.

Oxygen-heterocyclic compound

3,6,2',4',5'-Pentamethoxyflavone is a flavonoid compound, which is a type of polyphenolic secondary metabolite found in various plants. It is isolated from certain plant species known for their medicinal properties, such as Orthosiphon stamineus. This compound is characterized by the presence of five methoxy groups attached to the flavone backbone, which is thought to significantly influence its biological activity. The mode of action of 3,6,2',4',5'-Pentamethoxyflavone involves interactions with cellular signaling pathways, potentially inhibiting enzymes and modulating receptor activities. This multifaceted mode allows it to exert effects on various biochemical targets within the cell, thereby influencing physiological and pathological processes. This compound has been extensively studied for its potential applications in pharmacology. It exhibits a range of activities, including anti-inflammatory, antioxidant, and cytotoxic effects, making it a candidate for therapeutic development in treating diseases such as cancer and inflammatory disorders. Moreover, its natural occurrence and derivation from plants highlight its potential as a lead compound in the search for novel, plant-based pharmacological agents.

7,2',4'-Tribenzyloxy-8-methoxyisoflavone is a synthetic isoflavone derivative, which is structurally modified for research purposes. It is typically derived from chemical manipulation of naturally occurring flavonoid compounds found in various plants. The compound is noted for its ability to modulate biochemical pathways due to its interaction with estrogen receptors and other cellular targets. This mode of action makes it particularly useful in the study of estrogenic activities and their implications in various biological processes. Researchers utilize this compound to explore its potential effects on cellular signaling pathways, including those involved in cancer research and endocrine studies. Its specific interactions with receptor sites and enzymes provide insights into the modulation of hormonal activities, making it a valuable tool for pharmacological investigations and drug development processes. Due to its structural properties, it often serves as a prototype molecule in the synthesis of other derivatives aimed at enhancing specific bioactivities.

Quercetin 3,7,4'-trimethylether is a flavonoid derivative, which is a naturally occurring compound. It is sourced from various plants where it acts as a secondary metabolite. Its mode of action involves the modulation of signaling pathways and the inhibition of certain enzymes. Specifically, it has demonstrated the ability to interfere with cellular processes fundamental to cancer progression, such as proliferation and apoptosis. Research into Quercetin 3,7,4'-trimethylether indicates its potential for use in therapeutic applications, particularly in oncology. It exhibits antioxidant properties that contribute to its ability to mitigate oxidative stress, a common factor in the development of chronic diseases. Furthermore, its role in modulating the immune response suggests broader applications in managing inflammatory conditions. Scientists are investigating its efficacy and safety profiles to better understand its potential benefits and limitations as a therapeutic agent.

7,3',4'-Trihydroxy-3,5-dimethoxyflavone is a flavonoid compound, which is a type of naturally occurring polyphenol. It is primarily derived from various plant sources, including medicinal herbs and fruits, known for their bioactive properties. The mode of action of this compound is associated with its antioxidant activity, which involves scavenging free radicals and reducing oxidative stress in biological systems. In scientific research, 7,3',4'-Trihydroxy-3,5-dimethoxyflavone is studied for its potential applications in pharmacology and biochemistry. Its antioxidant properties make it a point of interest for investigating therapeutic effects against diseases characterized by oxidative damage, such as neurodegenerative disorders and certain types of cancers. Additionally, it may influence signaling pathways involved in inflammation and cellular apoptosis, further extending its research applications. By understanding its molecular interactions and effects, researchers can explore its potential benefits in health science and drug development.

Natural glycoside

Natural glycoside

Manghaslin inhibits α-glucosidase and AChE, suggesting anti-diabetic benefits from litchi pulp.

Applications Vestitone reductase catalyzes a stereospecific NADPH-dependent reduction of (3R)-vestitone in the bio sysnthesis of antimicrobial isoflavonoid phytoalexin medicarpin. References Shao, H., et al.: J. Mol. Biol., 369, 265 (2007)