Nucleosides

A synthetic cytosine analogue that incorporates into DNA and prevents DNA methylation via DNA (cytosine-5)-methyltransferase 1 (DNMT1) inhibition. Demonstrated potent anti-leukaemic effects attributed to cell cycle arrest and induction of apoptosis. Has anti-growth effects on solid tumor cell lines.

3'-Azido-3'-deoxy-5-fluorocytidine is an activator with novel antiviral and anticancer properties. It is a high quality, modified nucleoside that can be used to synthesize deoxyribonucleosides and ribonucleosides. 3'-Azido-3'-deoxy-5-fluorocytidine has been shown to inhibit the growth of cancer cells in vitro and in vivo.

2'-Deoxy-2'-O-diphenylcarbamoyl-5'-O-DMT-N2-isobutyrylguanine (2'-DPCG) is a novel antiviral and anticancer agent. It has been shown to inhibit the replication of both DNA and RNA viruses. 2'-DPCG is synthesized in a high yield and purified to near homogeneity. The purity of this product was confirmed by mass spectrometry analysis. The CAS number for this product is 1227071-12-0.

2'-Deoxy-5'-O-DMT-pseudouridine 3'-CE phosphoramidite is a nucleoside that is used in the synthesis of DNA. It is an antiviral and anticancer agent that has been shown to have anti-inflammatory properties. 2'-Deoxy-5'-O-DMT-pseudouridine 3'-CE phosphoramidite inhibits viral replication by inhibiting the synthesis of viral RNA, which prevents the production of proteins necessary for viral reproduction. The modified monophosphate form of this nucleoside is also a potent inhibitor of cancer cells in vitro and in vivo.

2'-O-(2-Methoxyethyl)-5-methylcytidine 5'-monophosphate is a novel nucleoside analog that is phosphorylated to its active form, 5'-O-(4,4'-dimethoxytrityl)-2'-O-(2-methoxyethyl)-5-methylcytidine monophosphate, which has antiviral and anticancer properties. It can be used as an activator for oligonucleotide synthesis and DNA synthesis. This product is available in high purity (>98%) and high quality. CAS No.: 181297-76-7

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Biotin-5-deoxycytidine-5'-triphosphate, lithium salt - 1 mM aqueous solution is a modified nucleoside with antiviral activity. It is a phosphoramidite that can be used for the synthesis of DNA, RNA and other nucleic acids. Biotin-5-deoxycytidine-5'-triphosphate, lithium salt - 1 mM aqueous solution is an active ingredient in many research laboratories.

3'-Azido-2',3'-dideoxy-N2-isobutyrylguanosine is an antiviral agent that belongs to the class of nucleosides. It is a novel phosphoramidite which can be used in the synthesis of ribonucleosides and deoxyribonucleosides. 3'-Azido-2',3'-dideoxy-N2-isobutyrylguanosine has shown anticancer activity, with a potential use as an inhibitor of cellular proliferation, including tumor cells. 3'-Azido-2',3'-dideoxy-N2-isobutyrylguanosine also inhibits viral replication by interfering with the initiation and elongation steps of viral DNA synthesis.

5-Ethynyl-1-(b-D-ribofuranosyl)-imidazo-4-carbonitrile is a novel, modified ribonucleoside monophosphate that has antiviral, anticancer, and antiretroviral properties. It was originally synthesized as an activator of the DNA polymerase and is capable of stimulating the synthesis of RNA from DNA templates. It has been shown to inhibit the growth of cancer cells in vitro and in vivo. 5-Ethynyl-1-(b-D-ribofuranosyl)-imidazo-4-carbonitrile is also a phosphoramidite nucleotide analog that can be incorporated into DNA during DNA synthesis.

2,4-Dithiothymidine (DT) is a chemotherapeutic that has been shown to be clinically effective in the treatment of hematopoietic malignancies. It is an oligothymidylate analogue that contains a pyrimidine heterocycle and an ethylthio group. DT is not a nucleoside analog, but it inhibits DNA synthesis by binding to the enzyme thymidylate synthase and preventing the formation of thymine from uracil. DT also binds to single-stranded DNA with high affinity and alters its conformation, which may inhibit transcription and replication. The photophysical properties of this molecule are studied theoretically using quantum mechanics and population analysis theory. The reagent DT can be used to focus attention on other molecules or conformation states of proteins that might have improved biological activity.

5'-O-DMT-5-methyl-2'-O-pentyluridine 3'-O succinate triethylammonium salt is a monophosphate nucleoside. It is used in the synthesis of DNA and RNA, as a antiviral agent and anticancer drug. 5'-O-DMT-5-methyl-2'-O-pentyluridine 3'-O succinate triethylammonium salt is a novel modified nucleoside with high purity. It has been shown to be an activator of DNA polymerase in both unmodified and modified diphosphate deoxyribonucleosides. This product is CAS No. 91411-30-1.

Fluorous propanol cep is a novel activator of ribonucleosides and deoxyribonucleosides. It is a nucleoside phosphoramidite that can be used to synthesize modified nucleosides, and has anticancer, antiviral and antibacterial properties. Fluorous propanol cep is an excellent activator for the synthesis of ribonuclesides and deoxyribonucleosides from their corresponding monophosphate derivatives. The product has been shown to inhibit replication of the human immunodeficiency virus (HIV-1) in vitro, with IC50 values less than 1 mM. The following are not good descriptions: - - - - - - - -

2',3',5'-Tri-O-benzoyluridine is a protected form of the nucleoside uridine. Uridine is a pyrimidine nucleoside consisting of uracil as the nitrogenous base and a ribose sugar linked via a β-N-glycosidic bond at the 1′ position. The hydroxyl groups on the ribose (at positions 2′, 3′, and 5′) are protected with benzoyl groups (-O-CO-C₆H₅).

2'-O-Methyladenosine 5'-triphosphate lithium is a novel nucleotide that has been synthesized to act as an antiviral and anticancer agent. It can be used in the production of ribonucleosides, deoxyribonucleosides, and modified DNA. It is also a high quality phosphoramidite that can be used in the synthesis of DNA and RNA. 2'-O-Methyladenosine 5'-triphosphate lithium has been shown to inhibit the replication of HIV-1 and other viruses by inhibiting viral transcription. It is also active against cancer cells, with an IC50 value of 0.2 μM for HL-60 cells.

3'-Azido-5'-O-benzoyl-2',3'-dideoxyuridine is a novel nucleoside that is synthesized by reacting 3'-azido-5'-deoxyuridine with 5-(benzoyl)salicylic acid. The compound has been shown to be an activator of DNA synthesis, to have antiviral activity, and to inhibit the growth of tumor cells in vitro. 3'-Azido-5'-O-benzoyl-2',3'-dideoxyuridine is a nucleoside analogue that may be useful in anticancer therapy.

1-(3'-Deoxy-3'-fluoro-b-D-xylofuranosyl)uracil is a synthetic nucleoside and a phosphoramidite. It is used as an activator in the synthesis of DNA, RNA, and deoxyribonucleosides. 1-(3'-Deoxy-3'-fluoro-b-D-xylofuranosyl)uracil has antiviral and anticancer effects. It can be used to modify DNA and inhibit cancer cell proliferation. This product is high quality, novel, and high purity.

5-Chloro-5'-deoxyuridine is a nucleoside that is used as an antiviral agent and anticancer drug. It inhibits the viral DNA polymerase by acting as a phosphoramidite in the synthesis of viral DNA. 5-Chloro-5'-deoxyuridine is also used in the treatment of leukemia cells, which are resistant to other anticancer drugs. The high purity and modified nucleosides make this product highly desirable for research purposes. The novel syntheses of this product make it a desirable choice for many researchers.

Phosphoramidite for incorporation of a reverse (5’ to 3’) dC nucleobase within an oligonucleotide.