Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa
- CDK
- Detención del ciclo celular
- Chk
- c-Myc
- Dynamin
- DYRK
- Ferroptosis
- HSP
- Integrin
- Kinesina
- KSP
- LIM quinasa
- Asociado a microtúbulos
- PKC
- PLK
- Rho
- ROCK
- Wee1
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Productos de "Ciclo celular / Checkpoint"
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2-Methylbiphenyl-oxadiazole-NH-Ph-NH-PEG3-C2-NH-Boc
2-Methylbiphenyl-oxadiazole-NH-Ph-NH-PEG3-C2-NH-Boc is the PD-L1 ligand-linker polymer of AUTACPD-L1degrader-3. It can be utilized in the synthesis of AUTAC.Fórmula:C35H45N5O6Forma y color:SolidPeso molecular:631.76Clofarabine-5'-triphosphate
CAS:Clofarabine-5'-triphosphate is a metabolite of Clofarabine, produced via phosphorylation by deoxycytidine kinase (dCK). It exhibits cytotoxicity in cancer cells by inhibiting DNA synthesis and DNA repair.Fórmula:C10H14ClFN5O12P3Forma y color:SolidPeso molecular:543.62PD-1/PD-L1-IN-10
CAS:PD-1/PD-L1-IN-10 is an orally available PD-1/PD-L1 inhibitor (IC50 value of 2.7 nM) that shows anti-tumor activity.Cost-effective and quality-assured.Fórmula:C33H31N3O7Pureza:97.81%Forma y color:SolidPeso molecular:581.62CDK9-IN-26
CDK9-IN-26, also known as compound 1, is a potent inhibitor of Cyclin-Dependent Kinase 9 (CDK9) with an IC50 value of 0.18 μM.[1]Fórmula:C17H14N4O2Pureza:98%Forma y color:SolidPeso molecular:306.32Leukadherin-1
CAS:Leukadherin-1 boosts CD11b/CD18 adhesion, lowers leukocyte movement, cuts inflammation.Fórmula:C22H15NO4S2Pureza:98% - 98.49%Forma y color:SolidPeso molecular:421.49Palbociclib orotate
CAS:Palbociclib (PD 0332991) orotate, an orally active selective inhibitor of CDK4 and CDK6, exhibits IC50 values of 11 and 16 nM, respectively.Fórmula:C29H33N9O6Pureza:98%Forma y color:SolidPeso molecular:603.63Acelarin
CAS:Acelarin (NUC-1031) (NUC-1031) is a ProTide enhancement and transformation of the nucleoside analog, gemcitabine.Fórmula:C25H27F2N4O8PPureza:99.26%Forma y color:SolidPeso molecular:580.47Ref: TM-T4060
1mg46,00€2mg59,00€5mg87,00€10mg144,00€25mg274,00€50mg487,00€100mg708,00€1mL*10mM (DMSO)97,00€CM03
CAS:CM03 is a cell-selective G-quadruplex ligand with anti-cancer activity, stabilizing G4 genes, useful in pancreatic cancer research.Fórmula:C34H44N6O6Pureza:98.65%Forma y color:SolidPeso molecular:632.75S-trityl-L-Cysteine
CAS:S-trityl-L-Cysteine is a potent inhibitor of human mitotic kinesin Eg5Fórmula:C22H21NO2SPureza:97.02%Forma y color:Almost White To Light Yellow Granular PowderPeso molecular:363.476-Bromo-2-hydroxy-3-methoxybenzaldehyde
CAS:6-Bromo-2-hydroxy-3-methoxybenzaldehyde (NSC-95682) is an inhibitor of IRE-1α (IC50 : 0.08 μM).Fórmula:C8H7BrO3Pureza:99.82%Forma y color:SolidPeso molecular:231.04TH287
CAS:TH287 is a potent inhibitor of MTH1 (NUDT1), less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16.Fórmula:C11H10Cl2N4Pureza:97.73% - 99%Forma y color:SolidPeso molecular:269.13Ref: TM-T2069
1mg37,00€2mg48,00€5mg72,00€10mg96,00€25mg188,00€50mg366,00€100mg545,00€1mL*10mM (DMSO)79,00€Litronesib
CAS:Litronesib is a selective inhibitor of mitosis-specific kinesin Eg5. It also has antitumor activity.Fórmula:C23H37N5O4S2Pureza:98%Forma y color:SolidPeso molecular:511.7Polθ-IN-6
CAS:Polθ-IN-6 (Compound 89) is an inhibitor of DNA polymerase theta (Polθ) and exhibits antitumor activity.Fórmula:C25H23N3O3SForma y color:SolidPeso molecular:445.53Aurora inhibitor 1
CAS:Aurora inhibitor 1 is a potent Aurora inhibitor (IC50: ≤ 4 nM and ≤13 nM for Aurora A and Aurora B kinase).Fórmula:C23H25N9SPureza:98%Forma y color:SolidPeso molecular:459.57WRN inhibitor 17
CAS:WRN inhibitor 17 (Compound 250) is an orally active inhibitor of Werner syndrome ATP-dependent helicase (WRN), specifically targeting the helicase domain activity of WRN. It holds potential for use in cancer research.Fórmula:C33H34F4N4O6SForma y color:SolidPeso molecular:690.71Palbociclib Isethionate
CAS:Palbociclib Isethionate (PD 0332991 isethionate) 是一种高选择性的CDK4/6抑制剂,IC50为11 nM 和16 nM。它对一组 36 种额外的蛋白激酶没有抑制作用。Fórmula:C24H29N7O2·C2H6O4SPureza:99.01% - 99.27%Forma y color:SolidPeso molecular:573.66Mps1-IN-3
CAS:Mps1-IN-3 is an effective and selective inhibitor of MPS1 kinase (IC50: 50 nM).Fórmula:C26H31N7O4SPureza:99.25%Forma y color:SolidPeso molecular:537.63Ref: TM-T16130
2mg42,00€5mg64,00€10mg92,00€25mg170,00€50mg311,00€100mg449,00€200mg630,00€1mL*10mM (DMSO)74,00€Danofloxacin
CAS:Danofloxacin (Danofloxacin free base) is a fluoroquinolone antibiotic used in veterinary medicine.Fórmula:C19H20FN3O3Pureza:99.77% - 99.80%Forma y color:SolidPeso molecular:357.38Moloney murine leukemia virus RT
Moloney murine leukemia virus reverse transcriptase (MMLV RT) is a monomeric replicative polymerase intrinsic to the retrovirus life cycle [1].Pureza:98%Forma y color:Odour SolidIMP-1088
CAS:IMP-1088 is a potent inhibitor of human N-myristoyltransferases NMT1 and NMT2 dual.Fórmula:C25H29F2N5OPureza:98.26% - 99.08%Forma y color:SolidPeso molecular:453.53Ref: TM-T9350
1mg144,00€2mg188,00€5mg283,00€10mg469,00€25mg833,00€50mg1.121,00€1mL*10mM (DMSO)310,00€
