Ciclo celular / Checkpoint
Los inhibidores del ciclo celular/puntos de control son compuestos que interrumpen la progresión normal del ciclo celular, particularmente en puntos de control regulatorios clave. Estos inhibidores son cruciales para estudiar la división celular, comprender la proliferación de células cancerosas y desarrollar terapias anticancerígenas. Al dirigirse a fases específicas del ciclo celular, estos inhibidores pueden inducir la detención del ciclo celular, lo que lleva a apoptosis o senescencia en células de división rápida. En CymitQuimica, ofrecemos una amplia gama de inhibidores de alta calidad del ciclo celular/puntos de control para apoyar su investigación en biología del cáncer, biología celular y desarrollo de fármacos.
Subcategorías de "Ciclo celular / Checkpoint"
- Aurora quinasa
- CDK
- Detención del ciclo celular
- Chk
- c-Myc
- Dynamin
- DYRK
- Ferroptosis
- HSP
- Integrin
- Kinesina
- KSP
- LIM quinasa
- Asociado a microtúbulos
- PKC
- PLK
- Rho
- ROCK
- Wee1
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Productos de "Ciclo celular / Checkpoint"
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HNC-1664
CAS:HNC-1664 is an orally active inhibitor of RNA-dependent RNA polymerase (RdRP). It exhibits broad-spectrum antiviral activity against coronaviruses, including SARS-CoV-2 wild type and its variants (XBB.1.18, HK.3.1, BF.7.14, BA.1, HCoV-229E, HCoV-OC43), as well as arenaviruses. HNC-1664 also demonstrates anti-infective efficacy in a mouse model infected with the SARS-CoV-2 Delta variant.Fórmula:C12H13FIN3O3Forma y color:SolidPeso molecular:393.153AZD-7762
CAS:AZD-7762, an effective and specific inhibitor of Chk1(IC50=5 nM), is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck.Fórmula:C17H19FN4O2SPureza:98.96% - 99.19%Forma y color:SolidPeso molecular:362.42Ref: TM-T6093
1mg38,00€2mg49,00€5mg81,00€10mg96,00€25mg177,00€50mg280,00€100mg449,00€1mL*10mM (DMSO)88,00€WBC100
CAS:WBC100 (14-D-Valine-TPL) is a potent, selective, and orally active c-Myc glue degrader that targets the ubiquitin E3 ligase CHIP-mediated 26S proteasome pathwayFórmula:C25H33NO7Pureza:98%Forma y color:SolidPeso molecular:459.53SB-218078
CAS:SB-218078 is less potently inhibits Cdc2 (IC50: 250 nM) and PKC (IC50: 1000 nM).Fórmula:C24H15N3O3Pureza:98%Forma y color:SolidPeso molecular:393.39Lusianthridin
CAS:Lusianthridin is a natural product from Dendrobium venustum.Fórmula:C15H14O3Pureza:99.11% - 99.11%Forma y color:SolidPeso molecular:242.27ddTTP trisodium
Dideoxythymidine triphosphate trisodium (ddTTP), a 2',3'-dideoxyribonucleoside 5'-triphosphate (ddNTP), functions as a chain-elongation inhibitor of DNAFórmula:C10H14N2Na3O13P3Pureza:98%Forma y color:SolidPeso molecular:532.11Danofloxacin mesylate
CAS:Danofloxacin mesylate (CP 76136-27) is a synthetic antibacterial agent of the fluoroquinolone class, acts principally by the inhibition of bacterial DNA-gyrase.Fórmula:C19H20FN3O3·CH4O3SPureza:99.73%Forma y color:Crystalline SolidPeso molecular:453.48SMN-C2
CAS:SMN-C2, a SMN2 gene splicing regulator, is an RNA-binding ligand that regulates pre-mRNA splicing and has potential for studying spinal muscular atrophy.Fórmula:C24H27N5O2Pureza:99.01%Forma y color:SolidPeso molecular:417.5NSC 23766
CAS:NSC 23766 is a Rac1 GTPase inhibitor by targeting GEFs, inhibiting cell proliferation.NSC23766 competitively inhibits M2 mAChR-induced Rac1 activation.Fórmula:C24H35N7Pureza:99.49%Forma y color:SolidPeso molecular:421.58Gentisin
CAS:Gentisin is a novel inhibitor of vascular smooth muscle cells (VSMC) proliferation with an IC50 value of 7.84 μM. Gentisin has mutagenic activity.Fórmula:C14H10O5Pureza:95.34%Forma y color:SolidPeso molecular:258.23GFB-12811
CAS:GFB-12811 is an orally active, selective, and potent CDK5 inhibitor, used in the study of autosomal dominant polycystic kidney disease.Fórmula:C22H23F4N5OPureza:98.88%Forma y color:SolidPeso molecular:449.44L-Uridine
CAS:L-Uridine, an RNA component from Poria cocos fungus, is a D-uridine enantiomer with antiviral potential and a phosphate acceptor.Fórmula:C9H12N2O6Pureza:99.57%Forma y color:SolidPeso molecular:244.2LFM-A13
CAS:LFM-A13(IC50=2.5 μM), a specific Bruton's tyrosine kinase (BTK), is more than 100-fold specificity than other protein kinases, such as JAK1, JAK2, HCK, EGFR,Fórmula:C11H8Br2N2O2Pureza:99.9%Forma y color:SolidPeso molecular:360qsl-304
QSL-304 is a DNA gyrase B inhibitor that serves as an antibacterial agent, exhibiting an IC50 of 31.23 mg/mL against Staphylococcus aureus SA-P2003 [1].Fórmula:C11H9NO4S2Pureza:98%Forma y color:SolidPeso molecular:283.32Tetrapeptide
CAS:Tetrapeptide, an α-MSH analogue, stimulates melanin production and mitigates DNA damage by attenuating reactive oxidative species generation and augmenting DNAFórmula:C32H40N10O5Pureza:98%Forma y color:SolidPeso molecular:644.72CDK9-IN-10
CAS:CDK9-IN-10 is a potent CDK9 inhibitor and the ligand for the PROTAC CDK9 degrader-2.Fórmula:C22H16O5Pureza:99.8%Forma y color:SolidPeso molecular:360.36Methotrexate metabolite
CAS:DAMPA, active metabolite of Methotrexate, is a chemotherapeutic and immunosuppressive folic acid antagonist.Fórmula:C15H15N7O2Pureza:95.28% - 99.7%Forma y color:SolidPeso molecular:325.33XMD-17-51
CAS:XMD-17-51 has DCLK1 kinase inhibitory activity, inhibits DCLK1 and cell proliferation, and can be used in lung cancer research.Fórmula:C21H24N8OPureza:99.39%Forma y color:SoildPeso molecular:404.47Pidilizumab
CAS:Pidilizumab (CT-011), a humanized IgG1κ anti-PD-1 monoclonal antibody, serves as a DLL1 antagonist with potential applications in researching hematologicPureza:98%Forma y color:LiquidLZ9
CAS:LZ9 is an ATP-competitive inhibitor of CDK1 and CDK2, with potential applications in colorectal cancer (CRC) research.Fórmula:C17H11F3N4O2Forma y color:SolidPeso molecular:360.29
