HSP
Los inhibidores de proteínas de choque térmico (HSP) se dirigen a las HSP, una familia de chaperonas moleculares que asisten en el plegamiento de proteínas, la estabilidad y la protección contra daños inducidos por el estrés. Las HSP suelen estar sobreexpresadas en células cancerosas, ayudándolas a sobrevivir en condiciones estresantes como la hipoxia y la quimioterapia. Inhibir las HSP puede interrumpir estos mecanismos de protección, lo que conduce a la muerte celular. Por lo tanto, los inhibidores de HSP son valiosos en la terapia contra el cáncer y en la investigación de respuestas al estrés. En CymitQuimica, ofrecemos una amplia gama de inhibidores de HSP de alta calidad para apoyar su investigación en homeostasis de proteínas, respuestas al estrés y oncología.
Productos de "HSP"
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NDNA4
NDNA4 (compound 17) is a selective Hsp90α inhibitor (IC50: 0.34 μM), characterized by its permanent charge and low membrane permeability.Fórmula:C31H35F3N2O5SPureza:98%Forma y color:SolidPeso molecular:604.68Paeoniflorin
CAS:Paeoniflorin (Peoniflorin) is a herbal constituent extracted from the root of Paeonia albiflora Pall.Fórmula:C23H28O11Pureza:96.9% - 97.16%Forma y color:White Fine PowderPeso molecular:480.46Hsp110-STAT3 interaction-IN-2
Hsp110-STAT3 interaction-IN-2 (compound 10b) is an inhibitor of the Hsp110-STAT3 interaction. It is utilized in research related to pulmonary arterial hypertension (PAH).Fórmula:C24H18F3N5O3Forma y color:SolidPeso molecular:481.43Tanespimycin
CAS:Tanespimycin (KOS 953) (17-AAG) is an inhibitor of Hsp90 that selectively inhibits BT474 tumor cell Hsp90 (IC50: 5 nM).Fórmula:C31H43N3O8Pureza:99.07% - 99.83%Forma y color:Dark Purple SolidPeso molecular:585.69KU-177
CAS:KU-177 is an Aha1 inhibitor that disrupts the interaction between Hsp90 and Aha1, eliminating cell proliferation and PI resistance induced by elevated AHSA1.Fórmula:C27H23NO8Pureza:97.34% - 98.54%Forma y color:SolidPeso molecular:489.47Calyxin H
CAS:Calyxin H at 1uM can increase the expression of heat shock factor 1 (HSF1), it has a possible application as a heat shock protein (HSP) inducer.Fórmula:C35H34O7Pureza:98%Forma y color:SolidPeso molecular:566.64SNX0723
CAS:SNX0723 is a potent Hsp90 Inhibitor with anti-Plasmodium activity.Fórmula:C22H26FN3O3Pureza:99.86%Forma y color:SolidPeso molecular:399.46Ref: TM-T28824
1mg89,00€5mg188,00€10mg316,00€25mg512,00€50mg702,00€100mg940,00€500mgA consultar1mL*10mM (DMSO)207,00€7-Aminocephalosporanic acid
CAS:7-Aminocephalosporanic acid (7-ACA) is used for synthesis of cephalosporin antibiotics and intermediates.Fórmula:C10H12N2O5SPureza:91.05% - 98.22%Forma y color:White Solid PowderPeso molecular:272.28HSP90-IN-23
HSP90-IN-23 (Comp 12-1), a heat shock protein 90 (HSP90) inhibitor, exhibits potent activity with an IC50 of 9nM.Fórmula:C22H24N2O6SPureza:98%Forma y color:SolidPeso molecular:444.5DN401
CAS:DN401 is a potent TRAP1 and Hsp90 Inhibitor( IC50 = 79 nM for TRAP1, IC50 = 698 nM for Hsp90) with potent anticancer activity.Fórmula:C13H9BrClN5O2Pureza:100%Forma y color:SolidPeso molecular:382.6Ref: TM-T27193
1mg185,00€5mg409,00€10mg605,00€25mg938,00€50mg1.293,00€100mg1.738,00€500mg3.496,00€1mL*10mM (DMSO)406,00€TRAP1-IN-2
CAS:TRAP1-IN-2, also known as compound 36, is a selective degrader of the TRAP1 client protein that does not affect Hsp90-cytosolic clients.Fórmula:C46H42F6N2O5P2Pureza:98%Forma y color:SolidPeso molecular:878.77Ethoxyquin
CAS:Ethoxyquin (Santoflex) is an antioxidant used in animal feeds.Fórmula:C14H19NOPureza:95.94%Forma y color:Yellow Liquid Mercaptan-Like Odor (Ntp 1992)Peso molecular:217.31Dihydroberberine
CAS:Dihydroberberine has anti-atherosclerotic, anti-inflammatory, hypolipidemic and antitumor activities.Fórmula:C20H19NO4Pureza:93.77%Forma y color:SolidPeso molecular:337.37Arimoclomol
CAS:Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP) and can be used in studies about the treatment of amyotrophic lateral sclerosis (Fórmula:C14H20ClN3O3Pureza:99.81%Forma y color:SolidPeso molecular:313.78Ref: TM-T13553
1mg115,00€5mg249,00€10mg369,00€25mg562,00€50mg787,00€100mg1.054,00€200mg1.406,00€1mL*10mM (DMSO)249,00€AT-533
CAS:AT-533 inhibits Hsp90, HSV, hinders HIF-1α/VEGF/VEGFR-2, Erk1/2, FAK, Akt/mTOR/p70S6K, and blocks tumor growth, angiogenesis, and HUVEC activities.Fórmula:C23H30N4O3Pureza:99.54%Forma y color:SoildPeso molecular:410.51Ref: TM-T67836
1mg51,00€5mg111,00€10mg170,00€25mg313,00€50mg467,00€100mg672,00€200mg905,00€1mL*10mM (DMSO)117,00€Novobiocin Sodium
CAS:Novobiocin Sodium (Albamycinsodium) binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound.Fórmula:C31H35N2NaO11Pureza:99% - 99.28%Forma y color:SolidPeso molecular:634.61Grp94 Inhibitor-1
CAS:Grp94 Inhibitor-1 is a potent, selective Grp94 inhibitor (IC50 : 2 nM).Fórmula:C22H28N2O2Pureza:97.02%Forma y color:SolidPeso molecular:352.47PF-04929113 Mesylate
CAS:PF-04929113 Mesylate (SNX-5422 Mesylate), a prodrug of SNX-2112, is an orally available Hsp90 inhibitor (Kd: 41 nM) and also induces Her-2 degradation (IC50: 37Fórmula:C26H34F3N5O7SPureza:99% - 99.46%Forma y color:SolidPeso molecular:617.63Ref: TM-T4342
1mg78,00€2mg100,00€5mg159,00€10mg288,00€25mg419,00€50mg615,00€100mg878,00€500mg1.776,00€1mL*10mM (DMSO)233,00€HS-27
CAS:HS-27 is a fluorescently-tethered inhibitor of Hsp90 with SNX-5422 tethered via a PEG linker to a fluorescein isothiocyanate or FITC.Fórmula:C52H60N6O12SPureza:97.09%Forma y color:SolidPeso molecular:993.13Ref: TM-T18018
1mg90,00€5mg215,00€10mg344,00€25mg612,00€50mg848,00€100mg1.159,00€1mL*10mM (DMSO)378,00€Onalespib
CAS:Onalespib (AT13387) is an oral Hsp90 inhibitor with anticancer potential, disrupting tumor cell growth and survival.Fórmula:C24H31N3O3Pureza:98.05% - 99.82%Forma y color:SolidPeso molecular:409.52
