HSP
Los inhibidores de proteínas de choque térmico (HSP) se dirigen a las HSP, una familia de chaperonas moleculares que asisten en el plegamiento de proteínas, la estabilidad y la protección contra daños inducidos por el estrés. Las HSP suelen estar sobreexpresadas en células cancerosas, ayudándolas a sobrevivir en condiciones estresantes como la hipoxia y la quimioterapia. Inhibir las HSP puede interrumpir estos mecanismos de protección, lo que conduce a la muerte celular. Por lo tanto, los inhibidores de HSP son valiosos en la terapia contra el cáncer y en la investigación de respuestas al estrés. En CymitQuimica, ofrecemos una amplia gama de inhibidores de HSP de alta calidad para apoyar su investigación en homeostasis de proteínas, respuestas al estrés y oncología.
Productos de "HSP"
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17-AEP-GA
CAS:17-AEP-GA is an HSP90 antagonist and a potent inhibitor of glioblastoma cell proliferation, survival, migration and invasion.Fórmula:C34H50N4O8Pureza:97.77% - 99.56%Forma y color:SolidPeso molecular:642.78Apoptozole
CAS:Apoptozole (Apoptosis Activator VII) is an inhibitor of the ATPase domain of Hsc70 and Hsp70, and can induce apoptosis.Fórmula:C33H25F6N3O3Pureza:99.75%Forma y color:SolidPeso molecular:625.56Ref: TM-T3293
2mg35,00€5mg50,00€10mg84,00€25mg137,00€50mg235,00€100mg349,00€200mg515,00€1mL*10mM (DMSO)66,00€VER49009
CAS:VER49009 (CCT0129397) is an effective HSP90 inhibitor(IC50 =25 nM, Kd=78 nM).Fórmula:C19H18ClN3O4Pureza:100% - 99.17%Forma y color:SolidPeso molecular:387.82Ref: TM-T2268
1mg60,00€2mg85,00€5mg111,00€10mg167,00€25mg283,00€50mg472,00€100mg643,00€1mL*10mM (DMSO)96,00€KU-32
CAS:KU-32 is a novel and novobiocin-based Hsp90 inhibitor. It can protect against neuronal cell death.Fórmula:C20H25NO8Pureza:98%Forma y color:SolidPeso molecular:407.41HSP90-IN-22
CAS:HSP90-IN-22 (Compound 35) is an Hsp90 inhibitor exhibiting antiproliferative activity, with IC50 values of 3.65 μM in MCF7 breast cancer cells and 2.71 μM inFórmula:C25H30N4O3Pureza:98%Forma y color:SolidPeso molecular:434.53XL888
CAS:XL888 is an orally bioavailable Hsp90 inhibitor, blocking cell proliferation and inducing tumor regression with an IC50 of 24 nM.Fórmula:C29H37N5O3Pureza:98.1%Forma y color:SolidPeso molecular:503.64PROTAC Hsp90α degrader 1
Compound X10g (PROTAC Hsp90α degrader 1) is a selective agent targeting Hsp90α for degradation and is utilized in breast cancer research.Fórmula:C43H50N6O7Pureza:98%Forma y color:SolidPeso molecular:762.89VER-155008
CAS:VER-155008 is a potent Hsp70 family inhibitor with IC50 of 0.5 μM, 2.6 μM, and 2.6 μM in cell-free assays for HSP70, HSC70, and GRP78, respectively.Fórmula:C25H23Cl2N7O4Pureza:98.88% - 99.55%Forma y color:SolidPeso molecular:556.4Ref: TM-T7010
2mg47,00€5mg69,00€10mg93,00€25mg163,00€50mg283,00€100mg467,00€200mg653,00€1mL*10mM (DMSO)85,00€CYP51/Hsp90-IN-1
CYP51/Hsp90-IN-1 (Compound MM4) is a dual inhibitor of CYP51 and Hsp90. This compound exhibits antifungal activity against Candida albicans and effectively suppresses key fungal virulence factors. CYP51/Hsp90-IN-1 shows potential for research in treating invasive candidiasis.Fórmula:C38H40F2N6O4Forma y color:SolidPeso molecular:682.76KW-2478
CAS:KW-2478 is a non-ansamycin HSP90 inhibitor with IC50 of 3.8 nM.Fórmula:C30H42N2O9Pureza:98.68% - 99.52%Forma y color:SolidPeso molecular:574.66Ref: TM-T6558
1mg56,00€2mg81,00€5mg119,00€10mg187,00€25mg316,00€50mg472,00€100mg662,00€1mL*10mM (DMSO)205,00€2',4'-DIHYDROXYCHALCONE
CAS:2',4'-DIHYDROXYCHALCONE (2',4'-DHC) as a compound with Hsp90 inhibitory and antifungal effectsFórmula:C15H12O3Pureza:98.95%Forma y color:SolidPeso molecular:240.25Ref: TM-T8829
2mg42,00€5mg62,00€10mg87,00€25mg154,00€50mg235,00€100mg354,00€200mg520,00€1mL*10mM (DMSO)65,00€Rocaglamide
CAS:Rocaglamide (Roc-A) from Aglaia treats coughs, injuries, asthma, skin issues, and inhibits NF-κB in T-cells.Fórmula:C29H31NO7Pureza:95.32% - 98.46%Forma y color:SolidPeso molecular:505.56Feretoside
CAS:Feretoside is a natural product extracted from the barks of E. ulmoides. Feretoside shows inducible activity on the heat shock factor 1 (HSF1).Fórmula:C17H24O11Pureza:99.15%Forma y color:SolidPeso molecular:404.37Ref: TM-TQ0280
1mg85,00€5mg180,00€10mg274,00€25mg465,00€50mg663,00€100mg919,00€500mg1.833,00€1mL*10mM (DMSO)298,00€PU-H54
CAS:PU-H54 is a purine-derived Grp94 inhibitor targeting the S2 subpocket's unique binding region.Fórmula:C18H19N5SPureza:99.13%Forma y color:SolidPeso molecular:337.44PF04929113
CAS:PF04929113 (SNX-5422), a synthetic small molecule Hsp90 inhibitor, offers potent efficacy orally for various cancers.Fórmula:C25H30F3N5O4Pureza:99.06%Forma y color:SolidPeso molecular:521.53Ref: TM-T6341
1mg39,00€2mg49,00€5mg84,00€10mg119,00€25mg187,00€50mg354,00€100mg527,00€1mL*10mM (DMSO)96,00€HSP90-IN-19
CAS:HSP90-IN-19: potent Hsp90 inhibitor, IC50 = 0.27 μM, used in research on viral diseases, neurodegeneration, inflammation.Fórmula:C29H38O7Pureza:98%Forma y color:SolidPeso molecular:498.61HSP90-IN-32
CAS:HSP90-IN-32, a carboxy-terminus inhibitor of Hsp90C, exhibits antiproliferative activity in various cell lines including SKMel173, SKMel103, SKMel19, and A375, with IC50 values of 1.01 μM, 0.782 μM, 0.607 μM, and 1.413 μM, respectively. This compound holds potential for research in anticancer agents.Fórmula:C33H40N2O4Forma y color:SolidPeso molecular:528.68NMS-E973
CAS:NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.Fórmula:C22H22N4O7Pureza:99.82%Forma y color:SolidPeso molecular:454.43Ref: TM-T6609
2mg42,00€5mg64,00€10mg97,00€25mg197,00€50mg310,00€100mg442,00€200mg622,00€1mL*10mM (DMSO)70,00€Calenduloside E
CAS:Calenduloside E (Silphioside F) exhibits hypoglycemic activities by suppressing the transfer of glucose from the stomach to the small intestine and byFórmula:C36H56O9Pureza:96.16%Forma y color:SolidPeso molecular:632.822-hexyl-4-Pentynoic Acid
CAS:2-hexyl-4-Pentynoic Acid, a valproic acid (VPA) derivatives, is a potent and robust HDACs inhibitor with IC50 value of 13 μM.Fórmula:C11H18O2Pureza:98%Forma y color:SolidPeso molecular:182.26
