HSP
Los inhibidores de proteínas de choque térmico (HSP) se dirigen a las HSP, una familia de chaperonas moleculares que asisten en el plegamiento de proteínas, la estabilidad y la protección contra daños inducidos por el estrés. Las HSP suelen estar sobreexpresadas en células cancerosas, ayudándolas a sobrevivir en condiciones estresantes como la hipoxia y la quimioterapia. Inhibir las HSP puede interrumpir estos mecanismos de protección, lo que conduce a la muerte celular. Por lo tanto, los inhibidores de HSP son valiosos en la terapia contra el cáncer y en la investigación de respuestas al estrés. En CymitQuimica, ofrecemos una amplia gama de inhibidores de HSP de alta calidad para apoyar su investigación en homeostasis de proteínas, respuestas al estrés y oncología.
Productos de "HSP"
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Gedunin
CAS:Gedunin, a Meliaceae seed limonoid, inhibits Hsp90 and ovarian cancer growth.Fórmula:C28H34O7Pureza:99.38% - 99.68%Forma y color:SolidPeso molecular:482.57Ref: TM-T21883
1mg393,00€5mg1.169,00€10mg1.596,00€25mg2.365,00€50mg3.192,00€100mg4.304,00€1mL*10mM (DMSO)1.283,00€NDNA3
NDNA3 (compound 14) selectively inhibits Hsp90α with an IC50 of 0.51 μM, demonstrating low membrane permeability and minimal toxicity to Ovcar-8 and MCF-10AFórmula:C28H32N2O3SPureza:98%Forma y color:SolidPeso molecular:476.63TRAP1-IN-1
TRAP1-IN-1 (compound 35) is a potent, selective TRAP1 inhibitor affecting the mitochondrial variant of Hsp90.Fórmula:C45H39F7N2O4P2Pureza:98%Forma y color:SolidPeso molecular:866.74HSP90-IN-25
HSP90-IN-25 (compound 4a) is an inhibitor targeting HSP90, specifically impeding its ATPase function [1].Fórmula:C29H48O10Pureza:98%Forma y color:SolidPeso molecular:556.69KUNG65
CAS:KUNG65 acts as a selective Grp94 inhibitor, demonstrating a target dissociation constant (K_d) of 540 nM. It exhibits a minimum selectivity of 73-fold compared to other Hsp90 isoforms.Fórmula:C23H20ClFO4Forma y color:SolidPeso molecular:414.85PU-H71 HCl
CAS:PU-H71 HCl (Zelavespib HCl) is a novel Hsp90 inhibitor, a novel purine-based analog, and a radiosensitizer that may be a promising agent for CIRT.Fórmula:C18H22ClIN6O2SPureza:98.95%Forma y color:SoildPeso molecular:548.83Hsp90-IN-38
CAS:Hsp90-IN-38 (compound 20m) is an inhibitor of HSP90 (heat shock protein). It demonstrates a strong binding affinity to HSP90 with a Kd of 87 nM. The compound inhibits ATPase activity with an IC50 of 0.13 μM. Hsp90-IN-38 also shows inhibitory effects on HCT116, MCF-7, SKBr3, K562, and A549 cells with IC50 values of 0.187, 0.072, 0.105, 0.403, and 0.031 μM, respectively.Fórmula:C28H35N3O5Forma y color:SolidPeso molecular:493.595TRC051384
CAS:TRC051384 is a HSP70 inducer that reduces stroke-associated neuronal damage and increases survival in a rat model of transient ischemic stroke.Fórmula:C25H31N5O4Pureza:92.66%Forma y color:SolidPeso molecular:465.54Ref: TM-T3527
1mg37,00€5mg80,00€10mg111,00€25mg210,00€50mg298,00€100mg432,00€200mg622,00€1mL*10mM (DMSO)81,00€Geldanamycin
CAS:Geldanamycin, an HSP90 inhibitor (Kd: 1.2 μM), specifically disrupts glucocorticoid receptor (GR)/HSP association.Fórmula:C29H40N2O9Pureza:98.83% - 99.27%Forma y color:Yellow To Orange PowderPeso molecular:560.64KRIBB11
CAS:KRIBB11 is an inhibitor of Heat shock factor (HSF) inhibitor.Fórmula:C13H12N6O2Pureza:97.25% - 99.91%Forma y color:SolidPeso molecular:284.27Ref: TM-T3652
5mg51,00€10mg77,00€25mg159,00€50mg263,00€100mg510,00€200mg717,00€500mg1.093,00€1mL*10mM (DMSO)52,00€Rifabutin
CAS:Rifabutin (LM-427), a semisynthetic ansamycin, blocks bacterial RNA synthesis by inhibiting RNA polymerase.Fórmula:C46H62N4O11Pureza:99.27% - 99.8%Forma y color:Red-Violet Crystalline PowderPeso molecular:847Tasiamide B
CAS:Tasiamide B is a linear peptide and Cathepsin D inhibitor discovered in the marine cyanobacterium Symploca sp. This compound serves as an excellent template for the development of aspartic protease inhibitors. Tasiamide B effectively targets skin cancer through its strong interaction with the protein HSP90.Fórmula:C50H74N8O12Forma y color:SolidPeso molecular:979.17AMP-PCP
CAS:AMP-PCP is an ATP analog and can bind to the Hsp90 N-terminal domain (Kd: 3.8 μM). AMP-PCP binding favors the formation of the active homodimer of Hsp90.Fórmula:C11H18N5O12P3Pureza:98%Forma y color:SolidPeso molecular:505.212-Methoxyhydroquinone
CAS:2-Methoxyhydroquinone is a phenolic compound that reduces the production of TNF-α-induced chemokine (C-C motif) ligand 2 (CCL2) with an IC50 value of 64.3 µM. It also serves as a synthetic precursor to the Hsp90 inhibitor Geldanamycin.Fórmula:C7H8O3Forma y color:SolidPeso molecular:140.14MKT-077
CAS:MKT-077 (FJ-776) is a cationic rhodacyanine dye that demonstrates antiproliferative activity against cancer cell lines.Fórmula:C21H22ClN3OS2Pureza:98.2%Forma y color:SolidPeso molecular:432BIIB021
CAS:BIIB021 (CNF2024) is an orally-available, fully synthetic inhibitor of HSP90(Ki=1.7 nM, EC50=38 nM).Fórmula:C14H15ClN6OPureza:98% - 99.82%Forma y color:SolidPeso molecular:318.763-Phenyltoxoflavin
CAS:3-Phenyltoxoflavin (Phenyltoxoflavin) is an inhibitor of HSP90 (Kd = 585 nM) with anti-cancer activity.Fórmula:C13H11N5O2Pureza:98.84%Forma y color:SolidPeso molecular:269.26Ref: TM-T36123
1mg57,00€5mg120,00€10mg187,00€25mg338,00€50mg512,00€100mg753,00€200mg1.035,00€1mL*10mM (DMSO)133,00€CH5138303
CAS:CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM.Fórmula:C19H18ClN5O2SPureza:98%Forma y color:SolidPeso molecular:415.9TRC051384 HCl
CAS:TRC051384 is an inducer of heat shock protein Hsp70, activating heat shock factor-1 and enhancing Hsp72 expression in neurons and glial cells.Fórmula:C25H32ClN5O4Pureza:97.55%Forma y color:SolidPeso molecular:502.01AMP-PCP disodium
CAS:AMP-PCP disodium is an ATP analogue with binding affinity to the N-terminal domain of Hsp90, with a Kd value of 3.8 μM.Fórmula:C11H16N5Na2O12P3Pureza:100%Forma y color:SolidPeso molecular:549.17
