HSP
Los inhibidores de proteínas de choque térmico (HSP) se dirigen a las HSP, una familia de chaperonas moleculares que asisten en el plegamiento de proteínas, la estabilidad y la protección contra daños inducidos por el estrés. Las HSP suelen estar sobreexpresadas en células cancerosas, ayudándolas a sobrevivir en condiciones estresantes como la hipoxia y la quimioterapia. Inhibir las HSP puede interrumpir estos mecanismos de protección, lo que conduce a la muerte celular. Por lo tanto, los inhibidores de HSP son valiosos en la terapia contra el cáncer y en la investigación de respuestas al estrés. En CymitQuimica, ofrecemos una amplia gama de inhibidores de HSP de alta calidad para apoyar su investigación en homeostasis de proteínas, respuestas al estrés y oncología.
Productos de "HSP"
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VER-82576
CAS:VER-82576 (NVP-BEP800), a synthetic HSP90β inhibitor (IC50: 58 nM), exhibits >70-fold selectivity against Hsp90 family members Trap-1 and Grp94.Fórmula:C21H23Cl2N5O2SPureza:98% - 99.16%Forma y color:SolidPeso molecular:480.41HSP90-IN-35
CAS:HSP90-IN-35 is an inhibitor targeting Hsp90, exhibiting anticancer activity. It demonstrates an IC50 ranging from 0.05 to 0.5 μM against Her2. Additionally, HSP90-IN-35 can be utilized in the synthesis of PROTAC.Fórmula:C27H33N5O5Forma y color:SolidPeso molecular:507.58KNK437
CAS:KNK437 (Heat Shock Protein Inhibitor I), a pan-HSP inhibitor, suppresses the synthesis of inducible HSPs(HSP105, HSP72, and HSP40).Fórmula:C13H11NO4Pureza:98.90%Forma y color:SolidPeso molecular:245.23H2-Gamendazole
CAS:H2-Gamendazole: inhibits spermatogenesis, cancer therapy, targets heat shock proteins & EF1α, regulates Hsp90.Fórmula:C18H13Cl2F3N2O2Pureza:97.36%Forma y color:SolidPeso molecular:417.21Ref: TM-T72076
1mg78,00€5mg190,00€10mg284,00€25mg505,00€50mg677,00€100mg929,00€200mg1.225,00€1mL*10mM (DMSO)215,00€CC-99677
CAS:CC-99677 (Gamcemetinib) is a MK2 inhibitor targeting autoimmune diseases; potent in rat assays with IC50=156.3 nM & EC50=89 nM.Fórmula:C22H20ClN5O3SPureza:99.51%Forma y color:SolidPeso molecular:469.94Debio 0932
CAS:Debio 0932 (CUDC-305) is a Hsp9 inhibitor, apoptosis, and has the advantage of being orally available and cross the BBB for cancers NSCLC and neuroblastoma.Fórmula:C22H30N6O2SPureza:98.98%Forma y color:SolidPeso molecular:442.58NCT-58
CAS:NCT-58 is a potent HSP90 inhibitor that blocks Akt, downregulates HER family, and induces apoptosis in HER2+ breast cancer without triggering HSR.Fórmula:C27H34N2O5Pureza:98.75%Forma y color:SolidPeso molecular:466.57Ref: TM-T9996
2mg46,00€5mg85,00€10mg126,00€25mg259,00€50mg415,00€100mg662,00€200mg889,00€1mL*10mM (DMSO)207,00€Luminespib
CAS:Luminespib (VER-52296) is an HSP90 inhibitor that inhibits HSP90α and HSP90β. Luminespib has antitumor activity. Cost-effective and quality-assured.Fórmula:C26H31N3O5Pureza:98% - 99.26%Forma y color:SolidPeso molecular:465.54Ref: TM-T1989
5mg57,00€10mg81,00€25mg145,00€50mg221,00€100mg363,00€200mg540,00€500mg872,00€1mL*10mM (DMSO)63,00€HSF1A
CAS:HSF1A is a cell-permeable activator of HSF1 that protects mammalian cells against stress-induced apoptosis.Fórmula:C21H19N3O2S2Pureza:98.89%Forma y color:SolidPeso molecular:409.52Ref: TM-T4125
1mg55,00€2mg88,00€5mg139,00€10mg207,00€25mg462,00€50mg677,00€100mg938,00€1mL*10mM (DMSO)130,00€Chetomin
CAS:Chetomin (BRN0077366) is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolarFórmula:C31H30N6O6S4Pureza:98%Forma y color:Off-White To Fawn SolidPeso molecular:710.87SNX2112
CAS:SNX2112 (PF 04928473) is an orally active Hsp90 inhibitor, with a Kd of 16 nM.Fórmula:C23H27F3N4O3Pureza:98.9% - 99.46%Forma y color:SolidPeso molecular:464.48Ref: TM-T6305
1mg40,00€5mg85,00€10mg127,00€25mg220,00€50mg334,00€100mg477,00€200mg662,00€1mL*10mM (DMSO)87,00€CCT251236
CAS:CCT251236 is an orally available Pirin ligand obtained from a heat shock transcription factor 1 (hsf1) phenotypic screen.Fórmula:C32H32N4O5Pureza:98.82% - 99.89%Forma y color:SolidPeso molecular:552.62Ref: TM-T14905
1mg39,00€5mg116,00€10mg221,00€25mg457,00€50mg733,00€100mg1.111,00€200mg1.501,00€1mL*10mM (DMSO)144,00€HSP27 inhibitor J2
CAS:HSP27 inhibitor J2 (J2) (J2) is a HSP27 inhibitor, inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function ofFórmula:C13H12O4SPureza:99.51%Forma y color:SolidPeso molecular:264.3Ref: TM-T7265
1mg130,00€2mg185,00€5mg311,00€10mg472,00€25mg753,00€50mg1.064,00€100mg1.415,00€1mL*10mM (DMSO)455,00€HSP70-IN-1
CAS:HSP70-IN-1 is a heat shock protein (HSP) inhibitor and inhibits the growth of Kasumi-1 cells (IC50: 2.3 μM).Fórmula:C24H28N6O2SPureza:100%Forma y color:SolidPeso molecular:464.58Ref: TM-T3487
1mg96,00€5mg227,00€10mg354,00€25mg620,00€50mg847,00€100mg1.169,00€1mL*10mM (DMSO)230,00€Col003
CAS:Col003 is a selective and potent inhibitor of Hsp47 and competitively binds to the collagen-binding site on Hsp47 (IC50: 1.8 μM).Fórmula:C14H11NO4Pureza:98.67% - 99.03%Forma y color:SolidPeso molecular:257.24Ref: TM-T10860
2mg47,00€5mg70,00€10mg107,00€25mg216,00€50mg350,00€100mg542,00€200mg778,00€500mg1.169,00€1mL*10mM (DMSO)70,00€Eupalinolide A
CAS:Eupalinolide B is a natural product ,and demonstrates potent cytotoxicity against A-549, BGC-823, SMMC-7721, and HL-60 tumour cell lines.Fórmula:C24H30O9Pureza:98.18% - 99.22%Forma y color:SolidPeso molecular:462.49NVP-HSP990
CAS:NVP-HSP990 (HSP990) is an effective and specific HSP90α/β inhibitor (IC50: 0.6 /0.8 nM).Fórmula:C20H18FN5O2Pureza:97.63% - 99.32%Forma y color:SolidPeso molecular:379.39BX-2819
CAS:BX-2819 is an Hsp90 inhibitor that exhibits potent antiproliferative activity with an IC50 of 41 nM .Fórmula:C21H24N4O4SPureza:98%Forma y color:SolidPeso molecular:428.51EC 144
CAS:EC 144, a second-generation selective inhibitor of Hsp90 , inhibits tumor growth for Hsp90α and degradation of Her-2 in MCF-7 cells.Fórmula:C21H24ClN5O2Forma y color:SolidPeso molecular:413.9YUM70
CAS:YUM70 inhibits GRP78 (IC50: 1.5μM), inducing ER stress and apoptosis in pancreatic cancer.Fórmula:C21H19ClN2O4Pureza:97.25%Forma y color:SolidPeso molecular:398.84Ref: TM-T8901
1mg48,00€5mg96,00€10mg135,00€25mg264,00€50mg389,00€100mg553,00€200mg750,00€1mL*10mM (DMSO)96,00€
