Cromatina / Epigenética
Los inhibidores de cromatina/epigenética son compuestos que modulan la estructura y función de la cromatina o interfieren con modificaciones epigenéticas, como la metilación del ADN y la modificación de histonas. Estos inhibidores son herramientas esenciales para estudiar la regulación de la expresión génica y el papel de la epigenética en enfermedades como el cáncer, los trastornos neurológicos y las anomalías del desarrollo. Al dirigirse a los procesos epigenéticos, estos inhibidores pueden alterar los patrones de expresión génica y ofrecer nuevas vías terapéuticas. En CymitQuimica, ofrecemos una amplia selección de inhibidores de cromatina/epigenética de alta calidad para apoyar su investigación en biología molecular, genética y epigenética.
Subcategorías de "Cromatina / Epigenética"
Productos de "Cromatina / Epigenética"
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ARV-825
CAS:ARV-825: PROTAC recruits BRD4 to cereblon for rapid BRD4 degradation in all tested BL cells.Fórmula:C46H47ClN8O9SPureza:97.15% - 98%Forma y color:SolidPeso molecular:923.43BIX-01294 trihydrochloride
CAS:BIX-01294 trihydrochloride is an inhibitor of G9a histone methyltransferase.In a cell-free assay, the IC50=2.7 μM for G9a histone methyltransferase.Fórmula:C28H38N6O2·3HClPureza:99.41% - 99.95%Forma y color:SolidPeso molecular:600.02Ref: TM-T1959
1mg44,00€2mg55,00€5mg71,00€10mg107,00€25mg192,00€50mg274,00€100mg492,00€500mg1.103,00€1mL*10mM (DMSO)139,00€Eleven-Nineteen-Leukemia Protein IN-3
CAS:ENL YEATS inhibitor Eleven-Nineteen-Leukemia Protein IN-3, IC50 15.4 nM, orally active, suppresses MYC, stabilizes ENL in vitro.Fórmula:C28H27N5O2Pureza:98%Forma y color:SolidPeso molecular:465.55WIKI4
CAS:WIKI4 is a potent inhibitor of Wnt/β-catenin signaling and tankyrase 2 (TNKS2).Fórmula:C29H23N5O3SPureza:99.32% - 99.6%Forma y color:SolidPeso molecular:521.59Tozasertib
CAS:Tozasertib (MK-0457) is a pan-Aurora kinase inhibitor (Kis: 0.6/18/4.6 nM for Aurora A/Aurora B/Aurora C).Fórmula:C23H28N8OSPureza:99.99%Forma y color:SolidPeso molecular:464.59XD14
CAS:XD14 inhibits BET bromodomains with Kd: BRD4(1) 160nM, BRD2(1) 170nM, BRD3(1) 380nM, BRD3(2) 490nM, BRD2(2) 830nM, BRD4(2) 850nM.Fórmula:C20H27N3O5SPureza:98.4%Forma y color:SolidPeso molecular:421.51GSK-J4 Hydrochloride
CAS:GSK-J4 Hydrochloride (GSK J4 HCl) is a cell permeable, potent and selective histone demethylase(JMJD3 )inhibitor. It is an ethyl ester derivative of the GSK-J1.Fórmula:C24H28ClN5O2Pureza:97.95% - 98.23%Forma y color:SolidPeso molecular:453.97Ref: TM-T4383
1mg40,00€2mg52,00€5mg88,00€10mg127,00€25mg217,00€50mg363,00€100mg533,00€200mg745,00€1mL*10mM (DMSO)139,00€Amodiaquine dihydrochloride dihydrate
CAS:Amodiaquine dihydrochloride dihydrate (Amodiaquin hydrochloride) is an orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory effectsFórmula:C20H28Cl3N3O3Pureza:99.97%Forma y color:SolidPeso molecular:464.82ZEN-3219
CAS:ZEN-3219 is a BET inhibitor, which has inhibitory effect on BRD4(BD1), BRD4(BD2) and BRD4(BD1BD2).Fórmula:C19H18N2O3Pureza:99.06%Forma y color:SolidPeso molecular:322.36NVP-TNKS656
CAS:NVP-TNKS656 (TNKS656) is a highly potent, selective, and orally active TNKS2 inhibitor.Fórmula:C27H34N4O5Pureza:99.59%Forma y color:SolidPeso molecular:494.58Ref: TM-T3261
1mg46,00€2mg57,00€5mg88,00€10mg129,00€25mg261,00€50mg444,00€100mg652,00€1mL*10mM (DMSO)87,00€Ethyl 3,4-dihydroxybenzoate
CAS:Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain.Fórmula:C9H10O4Pureza:99.88%Forma y color:White Crystal Or PowderPeso molecular:182.17JQ-1 (carboxylic acid)
CAS:JQ-1 (carboxylic acid) is a cell-permeable BRD4 inhibitor with IC50s of 77 nM for BRD4(1) and 33 nM for BRD4(2)Fórmula:C19H17ClN4O2SPureza:99.14% - 99.9%Forma y color:SolidPeso molecular:400.88Aurora B inhibitor 1
CAS:Aurora B inhibitor 1 is an Aurora B (Aurora-1) inhibitor (Ki <0.010 uM) with potential anticancer activity for cancer research.Fórmula:C25H26ClF2N7O2Pureza:98.37%Forma y color:SolidPeso molecular:529.97TY-011
CAS:TY-011 is an inhibitor of Aurora A/B kinases. This compound induces DNA damage and cell apoptosis (Apoptosis) in human gastric cancer cells by promoting abnormal microtubule-kinetochore attachments, effectively suppressing cancer cell proliferation. The IC50 values for TY-011 in human gastric cancer cell lines range from 0.11-4.49 μM. It is utilized in research focused on gastric cancer.Fórmula:C18H16ClN5Forma y color:SolidPeso molecular:337.81Tetrahydrouridine
CAS:Tetrahydrouridine (NSC-112907; THU) is a multidrug resistance modulator.Fórmula:C9H16N2O6Pureza:98%Forma y color:SolidPeso molecular:248.23GSK9311
CAS:GSK9311 inhibits BRPF bromodomain (pIC50: 6.0 and 4.3 for BRPF1 and BRPF2, respectively).Fórmula:C24H31N5O3Pureza:98%Forma y color:SolidPeso molecular:437.53PRMT4-IN-3
PRMT4-IN-3 (compound 56) serves as a potent class I protein arginine methyltransferase (PRMT) inhibitor, specifically targeting PRMT4 with an IC50 value of 37Fórmula:C23H29N7OPureza:98%Forma y color:SolidPeso molecular:419.52Jaspamycin
CAS:Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα.Fórmula:C12H12N4O5Forma y color:SolidPeso molecular:292.25FD1024
CAS:FD1024 is a potent PIM inhibitor, displaying inhibitory concentrations (IC50s) of 1.96 nM, 38.9 nM, and 4.17 nM for PIM1, PIM2, and PIM3, respectively.Fórmula:C21H20F2N4O2SPureza:98%Forma y color:SolidPeso molecular:430.47Ginsenoside Rk1
CAS:Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures.Fórmula:C42H70O12Pureza:99.13%Forma y color:SolidPeso molecular:767
