Cromatina / Epigenética
Los inhibidores de cromatina/epigenética son compuestos que modulan la estructura y función de la cromatina o interfieren con modificaciones epigenéticas, como la metilación del ADN y la modificación de histonas. Estos inhibidores son herramientas esenciales para estudiar la regulación de la expresión génica y el papel de la epigenética en enfermedades como el cáncer, los trastornos neurológicos y las anomalías del desarrollo. Al dirigirse a los procesos epigenéticos, estos inhibidores pueden alterar los patrones de expresión génica y ofrecer nuevas vías terapéuticas. En CymitQuimica, ofrecemos una amplia selección de inhibidores de cromatina/epigenética de alta calidad para apoyar su investigación en biología molecular, genética y epigenética.
Subcategorías de "Cromatina / Epigenética"
Productos de "Cromatina / Epigenética"
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UNC0642
CAS:UNC0642 is an effective and specific G9a/GLP inhibitor (IC50< 2.5 nM).Fórmula:C29H44F2N6O2Pureza:98.75% - 99.5%Forma y color:SolidPeso molecular:546.7Ref: TM-T4166
1mg40,00€2mg52,00€5mg87,00€10mg131,00€25mg230,00€50mg378,00€100mg567,00€200mg825,00€1mL*10mM (DMSO)95,00€Amodiaquine
CAS:Amodiaquine is a synthetic aminoquinoline, used to treat malaria.Fórmula:C20H22ClN3OPureza:99.78%Forma y color:Crystals From Absolute Ethanol SolidPeso molecular:355.86Ref: TM-T8381
1mg52,00€2mg70,00€5mg96,00€10mg173,00€25mg304,00€50mg452,00€100mg647,00€1mL*10mM (DMSO)120,00€DDO-3055
CAS:DDO-3055 is an orally active PHD2 inhibitor utilized in studies related to anemia associated with chronic kidney disease.Fórmula:C17H13ClN2O5Forma y color:SolidPeso molecular:360.749BI-847325
CAS:BI-847325 is a selective dual inhibitor of MEK and aurora kinases (AK) with IC50 values of 4 and 15 nM for human MEK2 and AK-C, respectively.Fórmula:C29H28N4O2Pureza:97.13% - 97.54%Forma y color:SolidPeso molecular:464.56Ref: TM-T6785
1mg49,00€5mg97,00€10mg153,00€25mg296,00€50mg445,00€100mg660,00€200mg917,00€1mL*10mM (DMSO)97,00€Pumecitinib
CAS:Pumecitinib is a Janus kinase (JAK) inhibitor. Pumecitinib exhibits anti-inflammatory activity.Fórmula:C17H20N8O2SPureza:99.89%Forma y color:SoildPeso molecular:400.46LP99
CAS:LP99 is an epigenetic probe.Fórmula:C26H30ClN3O4SPureza:98.74%Forma y color:SolidPeso molecular:516.05Ref: TM-T15784
1mg43,00€5mg96,00€10mg145,00€25mg305,00€50mg442,00€100mgA consultar1mL*10mM (DMSO)97,00€SJ46421
SJ46421, a PROTAC protein degrader derived from (+)-JQ-1, targets KLHDC2. It efficiently forms a stable ternary complex with KLHDC2, exhibiting an IC50 of 7.8 nM. Furthermore, SJ46421 promotes the polyubiquitination of the BD2 domain of BRD2, BRD3, or BRD4.Fórmula:C42H41ClN8O5S2Forma y color:SolidPeso molecular:837.41LSD1-IN-6
CAS:LSD1-IN-6, a potent LSD1 inhibitor (IC50: 123 nM), enhances H3K4me2 without altering LSD1 expression. Reversible.Fórmula:C15H13BrN2O3Pureza:98%Forma y color:SolidPeso molecular:349.18JW 55
CAS:JW 55 (JW55) is an effective and selective β-catenin signaling pathway inhibitor, works by inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2Fórmula:C25H26N2O5Pureza:99.31% - 99.76%Forma y color:SolidPeso molecular:434.48LSD1-IN-38
LSD1-IN-38 (Compound 23e) is a reversible, orally active inhibitor of lysine-specific demethylase 1 (LSD1), with an IC50 of 1.2 nM. It effectively inhibits the proliferation of cancer cells MV4-11, Kasumi-1, and NCI-H526 with IC50 values of 5, 4, and 11 nM, respectively. Furthermore, LSD1-IN-38 activates CD86 expression with an EC50 of 0.034 μM and induces differentiation in MV4-11 cells. In mouse models, this compound demonstrates antitumor activity.Fórmula:C30H29F4N5Peso molecular:535.578BRD4770
CAS:BRD4770 is a histone methyltransferase G9a inhibitor and induces cell senescence.Fórmula:C25H23N3O3Pureza:99.82%Forma y color:SolidPeso molecular:413.47XY1
CAS:XY1 is a very close analogue of SGC707 (a potent, selective, and non-competitive inhibitor of PRMT3 with IC50 of 31 nM), It is intended to be used as aFórmula:C17H19N3O2Pureza:97.2% - 97.74%Forma y color:SolidPeso molecular:297.35E7016
CAS:E7016 (GPI 21016) is an orally available PARP inhibitor. E7016 inhibits of DNA repair. E7016 can enhance tumor cell radiosensitivity in vitro and in vivo.Fórmula:C20H19N3O3Pureza:98.16%Forma y color:SolidPeso molecular:349.38Fosifidancitinib
CAS:Fosifidancitinib is a potent inhibitor of JAK 1 and JAK 3.Fórmula:C21H21FN5O7PPureza:99.55%Forma y color:SolidPeso molecular:505.39Ref: TM-T38624
1mg87,00€2mg124,00€5mg187,00€10mg284,00€25mg452,00€50mg645,00€100mg867,00€200mg1.159,00€PROTAC BRD3/BRD4-L degrader-2
PROTAC BRD3/BRD4-L degrader-2, a PROTAC molecule, selectively degrades cellular BRD3 and BRD4-L with K i values of 16.91 and 2.8 nM, respectively, and exhibitsFórmula:C43H44ClN7O3Pureza:98%Forma y color:SolidPeso molecular:742.31STAT3-IN-18
CAS:STAT3-IN-18 (compound SPP), a platinum (IV) complex featuring an axial ligand from sandalwood, suppresses the JAK2-STAT3 pathway in breast cancer (BC) cells andFórmula:C18H24Cl2N2O6PtPureza:98%Forma y color:SolidPeso molecular:630.38UNC0321
CAS:UNC0321 is an effective inhibitor of histone methyltransferase G9a with a Ki of 63 pM and with IC50s 9 nM and 6 nM in ECSD and CLOT assays.Fórmula:C27H45N7O3Pureza:99.25%Forma y color:SolidPeso molecular:515.69GXF-111
GXF-111, a proteolysis targeting chimera (PROTAC) molecule, efficiently induces the selective degradation of the BRD3 and BRD4-L proteins.Fórmula:C42H42ClN7O3Pureza:98%Forma y color:SolidPeso molecular:728.28JAK1-IN-8
CAS:JAK1-IN-8, a specific inhibitor of Janus kinase 1 (JAK1, IC50<500 nM).Fórmula:C22H23FN4O3SPureza:98.36%Forma y color:SolidPeso molecular:442.51Ref: TM-T35899
5mg47,00€10mg79,00€25mg144,00€50mg250,00€100mg424,00€200mg568,00€1mL*10mM (DMSO)50,00€MI-136
CAS:MI-136 inhibits expression of androgen receptor (AR) target genes that DHT induced.Fórmula:C23H21F3N6SPureza:97.08% - 98.63%Forma y color:SolidPeso molecular:470.51Ref: TM-T6889
1mg47,00€5mg87,00€10mg147,00€25mg279,00€50mg472,00€100mg730,00€200mg1.017,00€1mL*10mM (DMSO)97,00€
