NF-κB
El factor nuclear kappa-light-chain-enhancer de células B activadas (NF-κB) es un factor de transcripción que regula la expresión de genes involucrados en respuestas inmunitarias, inflamación, supervivencia celular y proliferación. El NF-κB se activa en respuesta a varios estímulos, incluidos citocinas, patógenos y señales de estrés. La desregulación de la señalización de NF-κB está asociada con enfermedades inflamatorias crónicas, cáncer y trastornos autoinmunes. En CymitQuimica, ofrecemos una selección integral de moduladores de la vía NF-κB para apoyar su investigación en inflamación, oncología y regulación inmunitaria.
Productos de "NF-κB"
Ordenar por
Muscone
CAS:Muscone (3-Methylcyclopentadecanone) is an organic compound that is the primary contributor to the odor of musk.Fórmula:C16H30OPureza:99.28%Forma y color:Colourless Liquid LiquidPeso molecular:238.41TBK1-IN-1
TBK1-IN-1 is a TANK-binding kinase 1 inhibitor with anticancer activity.TBK1-IN-1 inhibits the expression of TBK1 downstream target genes, cxcl10 and ifnβ.Fórmula:C27H37N7O2Pureza:99.91%Forma y color:SolidPeso molecular:491.63Zingerone
CAS:Zingerone (Vanillylacetone) is a nontoxic methoxyphenol isolated from Zingiber officinale with potent anti-inflammatory, antidiabetic and anti-tumor properties.Fórmula:C11H14O3Pureza:99.38% - 99.85%Forma y color:Clear Slightly Yellow LiquidPeso molecular:194.23PROTAC IRAK4 degrader-8
CAS:PROTAC IRAK4 Degrader-8 (Compound 2) is a PROTAC designed to target IRAK4 with an IC50 of 15.5 nM [1].Fórmula:C43H50ClF2N11O5Pureza:98%Forma y color:SolidPeso molecular:874.38WAY-169916
CAS:WAY-169916 inhibits ER by blocking NF-kB activity, lacks estrogenic effects.Fórmula:C17H13F3N2O2Pureza:98.63% - 98.64%Forma y color:SolidPeso molecular:334.29Ref: TM-T8981
2mg42,00€5mg64,00€10mg97,00€25mg197,00€50mg329,00€100mg475,00€200mg655,00€1mL*10mM (DMSO)94,00€Gue1654
CAS:Gue1654 is an OXE-R inhibitor and cardiomyocyte apoptosis.Gue1654 can be used for the study of cardiovascular diseases.Fórmula:C23H17N3OS3Pureza:98.02% - 98.31%Forma y color:SolidPeso molecular:447.6Malachite green oxalate
CAS:Malachite green oxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions.Fórmula:C23H25N2·C2HO4C2H2O4Forma y color:Dark Green Crystals With A Metallic LusterPeso molecular:463.51IMD-0354
CAS:IMD-0354 (IKK2 Inhibitor V) is an IKKβ inhibitor and inhibits IκBα phosphorylation in NF-κB pathway.Fórmula:C15H8ClF6NO2Pureza:99.56% - 99.71%Forma y color:SolidPeso molecular:383.67Ref: TM-T6141
2mg48,00€5mg66,00€10mg92,00€25mg163,00€50mg221,00€100mg310,00€500mg753,00€1mL*10mM (DMSO)69,00€RIP2 Kinase Inhibitor 3
CAS:RIP2 Kinase Inhibitor 3 is a potent and selective inhibitor of RIP2 with an IC50 of 1 nM.Fórmula:C19H24N4O3SPureza:98.28% - 98.35%Forma y color:SolidPeso molecular:388.48Benzoyloxypaeoniflorin
CAS:Benzoyloxypaeoniflorin, a natural compound, enhances blood flow by inhibiting platelet aggregation and coagulation.Fórmula:C30H32O13Pureza:97.64% - 98.7%Forma y color:SolidPeso molecular:600.57Ref: TM-T4S1658
1mg127,00€5mg298,00€10mg432,00€25mg697,00€50mg938,00€100mg1.293,00€1mL*10mM (DMSO)378,00€GSK319347A
CAS:GSK319347A is a dual inhibitor of TBK1 and IKKε that inhibits IKK2 and can be used to study bladder and lung adenocarcinomas.Fórmula:C22H19N3O5S2Pureza:98.42%Forma y color:SolidPeso molecular:469.53Ref: TM-T15558
1mg73,00€5mg153,00€10mg255,00€25mg535,00€50mg910,00€100mg1.216,00€1mL*10mM (DMSO)340,00€RIPK1-IN-16
CAS:RIPK1-IN-16 is an orally active, potent RIPK1 inhibitor that mitigates excessive inflammation via inhibition of RIPK1-mediated necroptosis in vivo.Fórmula:C20H19N5O2SPureza:98%Forma y color:SolidPeso molecular:393.46IRAK4-IN-20
CAS:IRAK4-IN-20 is a potent and orally active IRAK4 inhibitor (IC50:3.55 nM).Fórmula:C22H25F3N4O3Pureza:97.32%Forma y color:SolidPeso molecular:450.45Asatone
CAS:Asatone from Radix et Rhizoma Asari has anti-inflammatory properties, acting on NF-κB and suppressing p-MAPK pathways (ERK, JNK, p38).Fórmula:C24H32O8Pureza:99.84% - 99.92%Forma y color:SolidPeso molecular:448.51Ref: TM-T10383
1mg88,00€5mg202,00€10mg303,00€25mg509,00€50mg725,00€100mg938,00€500mg1.882,00€1mL*10mM (DMSO)198,00€BMS-345541 hydrochloride
CAS:BMS-345541 hydrochloride is a selective IKK inhibitor (IKK2 and IKK1 with IC50 of 0.3 μM and 4 μM,respectively).Fórmula:C14H18ClN5Pureza:99.13%Forma y color:SolidPeso molecular:291.78Ref: TM-T8542
1mg40,00€2mg52,00€5mg87,00€10mg126,00€25mg225,00€50mg376,00€100mg563,00€1mL*10mM (DMSO)55,00€Velutin
CAS:Velutin shows the strongest inhibitory effect in NF-κB activation and exhibits the greatest effects in blocking the degradation of inhibitor of NF-κB as well asFórmula:C17H14O6Pureza:99.69%Forma y color:SolidPeso molecular:314.29AZD3264
CAS:AZD3264 is a new type IKK2 inhibitor.Fórmula:C21H23N5O4SPureza:98.98% - 99.17%Forma y color:SolidPeso molecular:441.5Ref: TM-T6771
1mg52,00€2mg70,00€5mg103,00€10mg160,00€25mg311,00€50mg502,00€100mg805,00€500mg1.605,00€1mL*10mM (DMSO)114,00€IMM-H007
CAS:IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expressionFórmula:C22H23N5O8Pureza:97.73%Forma y color:SolidPeso molecular:485.45Ref: TM-T9010
1mg40,00€5mg96,00€10mg135,00€25mg226,00€50mg320,00€100mg434,00€200mg602,00€1mL*10mM (DMSO)131,00€PROTAC IRAK4 degrader-12
CAS:PROTAC IRAK4 degrader-12, a Cereblon ligand-based PROTAC, induces a maximum degradation of IRAK4 in K562 cells at 108.46% with an IC50 value of 4.87 nM. (Structure Note: Pink, IRAK4 Inhibitor; Blue, E3; Black, linker.)Fórmula:C46H50ClF2N11O6Forma y color:SolidPeso molecular:926.41BI-69A11
CAS:BI-69A11 is a dual AKT/NFkB inhibitor, increasing colon cancer cell sensitivity to mda-7/IL-24.Fórmula:C25H16ClN3O2Pureza:96.97%Forma y color:SolidPeso molecular:425.87Ref: TM-T25150
1mg46,00€2mg57,00€5mg82,00€10mg96,00€25mg180,00€50mg259,00€100mg369,00€1mL*10mM (DMSO)93,00€
