NF-κB
El factor nuclear kappa-light-chain-enhancer de células B activadas (NF-κB) es un factor de transcripción que regula la expresión de genes involucrados en respuestas inmunitarias, inflamación, supervivencia celular y proliferación. El NF-κB se activa en respuesta a varios estímulos, incluidos citocinas, patógenos y señales de estrés. La desregulación de la señalización de NF-κB está asociada con enfermedades inflamatorias crónicas, cáncer y trastornos autoinmunes. En CymitQuimica, ofrecemos una selección integral de moduladores de la vía NF-κB para apoyar su investigación en inflamación, oncología y regulación inmunitaria.
Productos de "NF-κB"
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SZM679
SZM679: Oral RIPK1 inhibitor, Kd 8.6 nM, weak RIPK3 affinity (>5000 nM). Reduces inflammation, Tau phosphorylation in AD research.Fórmula:C27H18F5N3O5SPureza:98%Forma y color:SolidPeso molecular:591.51IRAK4-IN-26
IRAK4-IN-26 (Compound 21), an IRAK4 inhibitor with an IC50 of 6.2 nM, exhibits an oral bioavailability of 21%.Fórmula:C22H23N5O3Pureza:98%Forma y color:SolidPeso molecular:405.45Antiproliferative agent-22
CAS:Antiproliferative agent-22 is an anticancer compound that shows antiproliferative activity on MCF-7, MDA-MB-231 and MDA-MB-468 cells.Fórmula:C17H13N3O3Pureza:99.20% - 99.30%Forma y color:SolidPeso molecular:307.31-Caffeoylquinic acid
CAS:1-Caffeoylquinic acid: a lignin precursor with anti-influenza, antioxidant properties, and moderates post-meal glucose release.Fórmula:C16H18O9Pureza:98.77% - 99.16%Forma y color:SolidPeso molecular:354.31Ref: TM-TN1051
1mg90,00€5mg243,00€10mg351,00€25mg548,00€50mg735,00€100mgA consultar1mL*10mM (DMSO)225,00€ETHYL CAFFEATE
CAS:Ethyl Caffeate (ETHYL 3,4-DIHYDROXYCINNAMATE) suppressed the differentiation of naive CD4+ T cells into Th1 in vitro.Fórmula:C11H12O4Pureza:97.79%Forma y color:SolidPeso molecular:208.21AZ1495
CAS:AZ1495: oral IRAK4 inhibitor (IC50: 5 nM), IRAK1 (23 nM), treats MYD88L265P DLBCL.Fórmula:C21H31N5O2Pureza:98.81%Forma y color:SolidPeso molecular:385.5Ref: TM-T14367
1mg87,00€5mg164,00€10mg259,00€25mg369,00€50mg520,00€100mg792,00€200mg1.064,00€1mL*10mM (DMSO)178,00€(E/Z)-IT-603
CAS:(E/Z)-IT-603 is a cell-permeable c-Rel inhibitor. IT-603 directly and reversibly binds to c-Rel to change its conformation and blocks its DNA binding activity.Fórmula:C11H9BrN2O3SPureza:99.35%Forma y color:SolidPeso molecular:329.17Ref: TM-T8799
1mg59,00€5mg126,00€10mg202,00€25mg406,00€50mg607,00€100mg845,00€500mg1.738,00€1mL*10mM (DMSO)140,00€Myrislignan
CAS:Myrislignan exhibits anti-inflammatory, anti-cancer properties, hinders NF-κB pathway, curbs A549 cell growth, and triggers apoptosis and cell cycle arrest.Fórmula:C21H26O6Pureza:98.77% - 99.41%Forma y color:SolidPeso molecular:374.43Ref: TM-T4S1540
1mg47,00€5mg93,00€10mg144,00€25mg250,00€50mg406,00€100mg592,00€1mL*10mM (DMSO)107,00€CBL0137
CAS:CBL0137 (Curaxin 137), a metabolically stable curaxin, activates p53 (EC50: 0.37 μM) and inhibits NF-κB (EC50: 0.47 μM).Fórmula:C21H24N2O2Pureza:99.57%Forma y color:SolidPeso molecular:336.434-Aminosalicylic acid
CAS:4-Aminosalicylic acid (para-aminosalicylic acid) is an analog of para-aminobenzoic acid (PABA) with antitubercular activity.Fórmula:C7H7NO3Pureza:97.07%Forma y color:Minute Crystals From Alc SolidPeso molecular:153.14IRAK-4 protein kinase inhibitor 2
CAS:IRAK-4 protein kinase inhibitor 2 is a potent interleukin-1 receptor-associated kinase-4 (IRAK-4) inhibitor(IC50 = 4 μM).Fórmula:C14H10N4O3Pureza:99.67%Forma y color:SolidPeso molecular:282.25BMS986299
CAS:BMS986299 is a modulator of NLRP3 with an EC50 of 1.28 μM and can be used in studies about NLRP3 signaling and the treatment of associated diseases.Fórmula:C18H19N7OPureza:99.93% - 99.93%Forma y color:SolidPeso molecular:349.39Esculentoside A
CAS:Esculentoside A dampens inflammation in ALI, modulates T cells, and could treat autoimmune diseases and BXSB mice by adjusting cytokines and renal cells.Fórmula:C42H66O16Pureza:98% - 99.85%Forma y color:SolidPeso molecular:826.96Dendrophenol
CAS:Dendrophenol (Moscatilin) is a natural product isolated from the stem of Dendrobium loddigesii Rolfe, act as a NF-κB inhibitor. Antineoplastic activity.Fórmula:C17H20O5Pureza:98.2% - 98.96%Forma y color:SolidPeso molecular:304.34Ref: TM-T3S1707
1mg104,00€2mg145,00€5mg227,00€10mg338,00€25mg558,00€50mg797,00€100mg1.074,00€1mL*10mM (DMSO)246,00€NF-κB-IN-10
NF-κB-IN-10 (compound E1) is an inhibitor of NF-κB that mitigates heart failure symptoms through the modulation of the Nrf2/NF-κB signaling pathway, alleviatingFórmula:C26H30N2O4Pureza:98%Forma y color:SolidPeso molecular:434.53DHMEQ racemate
CAS:DHMEQ racemate is an NF-κB inhibitor. The activity of DHMEQ racemate is lower than (-)-DHMEQ.Fórmula:C13H11NO5Pureza:98%Forma y color:SolidPeso molecular:261.23NLRP3-IN-13
CAS:NLRP3-IN-13 is an NLRP3 inhibitor that inhibits NLRP3-associated inflammation.NLRP3-IN-13 can be used in the study of neurological disorders and inflammation.Fórmula:C19H15N3O3SPureza:98.82%Forma y color:SolidPeso molecular:365.41E3330
CAS:E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.Fórmula:C21H30O6Pureza:98.83%Forma y color:SolidPeso molecular:378.46Ref: TM-T6823
1mg50,00€2mg72,00€5mg107,00€10mg167,00€25mg304,00€50mg500,00€100mg725,00€200mg1.017,00€500mg1.510,00€1mL*10mM (DMSO)88,00€Ginsenoside Rk3
CAS:Ginsenosides Rk3 & Rh4 may treat inflammation and ischemic heart disease.Fórmula:C36H60O8Pureza:99.33% - 99.88%Forma y color:SolidPeso molecular:620.86Ref: TM-T6S1495
1mg85,00€5mg172,00€10mg255,00€25mg426,00€50mg630,00€100mg898,00€1mL*10mM (DMSO)283,00€
