NF-κB
El factor nuclear kappa-light-chain-enhancer de células B activadas (NF-κB) es un factor de transcripción que regula la expresión de genes involucrados en respuestas inmunitarias, inflamación, supervivencia celular y proliferación. El NF-κB se activa en respuesta a varios estímulos, incluidos citocinas, patógenos y señales de estrés. La desregulación de la señalización de NF-κB está asociada con enfermedades inflamatorias crónicas, cáncer y trastornos autoinmunes. En CymitQuimica, ofrecemos una selección integral de moduladores de la vía NF-κB para apoyar su investigación en inflamación, oncología y regulación inmunitaria.
Productos de "NF-κB"
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PI-1840
CAS:PI-1840 is a reversible and selective chymotrypsin-like (CT-L) inhibitor, with little proteasome proteolytic effects on trypsin-like (T-L) and PGPH-L.Fórmula:C22H26N4O3Pureza:98.82%Forma y color:SolidPeso molecular:394.47Geranylgeraniol
CAS:Geranylgeraniol (FT0626663) is an isoprenoid found in fruits, vegetables, and grains, including rice.Fórmula:C20H34OPureza:99.89% - ≥98%Forma y color:SolidPeso molecular:290.48Triacetylresveratrol
CAS:Triacetylresveratrol (Acetyl-trans-resveratrol) has anti-cancer activity, it inhibits the phosphorylation of STAT3 and NFκB in pancreatic cancer cells.Fórmula:C20H18O6Pureza:99.81%Forma y color:Off White PowderPeso molecular:354.35Suberosin
CAS:Suberosin: anti-inflammatory, anticoagulant, deters Aedes aegypti bites, potential mosquito larvicide.Fórmula:C15H16O3Pureza:97.08% - 99.12%Forma y color:SolidPeso molecular:244.298-Deoxygartanin
CAS:8-Deoxygartanin is a butyrylcholinesterase (BChE) selective inhibitor, it exhibits significant inhibition of self-induced α2-amyloid (Aα2) aggregation, it hasFórmula:C23H24O5Pureza:99.04% - 99.76%Forma y color:SolidPeso molecular:380.43Madecassic acid
CAS:Madecassic acid (L-fucopyranose) is extracted from the whole herb of Centella asiatica.Fórmula:C30H48O6Pureza:98.80% - 99.69%Forma y color:SolidPeso molecular:504.7Anti-osteoporosis agent-4
Anti-osteoporosis agent-4 (Compound 11h) suppresses the differentiation of primary osteoclasts and attenuates RANKL-induced osteoclastogenesis.Fórmula:C26H26ClN3O7SPureza:98%Forma y color:SolidPeso molecular:560.02QNZ
CAS:QNZ (EVP4593) (EVP4593) is an effective inhibitor of NF-κB activation and TNF-α production. The IC50 of QNZ for NF-κB and TNF-α is11 nM and 7 nM, respectively.Fórmula:C22H20N4OPureza:98.16% - 99.17%Forma y color:White SolidPeso molecular:356.42Ref: TM-T6204
1mg43,00€2mg57,00€5mg93,00€10mg140,00€25mg226,00€50mg329,00€100mg490,00€1mL*10mM (DMSO)93,00€IKKγ NBD Inhibitory Peptide acetate
IKKγ NBD Inhibitory Peptide acetate is a NEMO-binding domain peptide (NBD peptide) acetate corresponding to the NEMO amino-terminal alpha-helical region.Pureza:99.15%Forma y color:SolidPeso molecular:N/ARef: TM-TP1615L
1mg131,00€2mg173,00€5mg255,00€10mg374,00€25mg625,00€50mg890,00€100mg1.206,00€500mg2.422,00€IKK-IN-1
CAS:IKK-IN-1 is an inhibitor of IKK.Fórmula:C22H26ClN3O4Pureza:98%Forma y color:SolidPeso molecular:431.91Okanin
CAS:Okanin shows significant activities on both linoleic acid peroxidation inhibition and DPPH radical scavenging effect.Fórmula:C15H12O6Pureza:95.19% - 99.4%Forma y color:SolidPeso molecular:288.25Ref: TM-TN2008
1mg88,00€5mg259,00€10mg311,00€25mg525,00€50mg750,00€100mg1.017,00€1mL*10mM (DMSO)217,00€RIP1 kinase inhibitor 7
CAS:RIP1 Kinase Inhibitor 7 (Compound 41) serves as a potent inhibitory agent for receptor interacting protein 1 kinase (RIP1) with an IC50 of under 100 nM.Fórmula:C20H20FN3OPureza:98%Forma y color:SolidPeso molecular:337.39Barlerin
CAS:Barlerin (8-O-Acetylshanzhiside methyl ester) has potential against cerebral ischemic injury, and protective effect on oxygen-glucose deprivation-induced injuryFórmula:C19H28O12Pureza:99.83% - ≥95%Forma y color:SolidPeso molecular:448.42Ref: TM-T5S1632
1mg40,00€2mg52,00€5mg85,00€10mg115,00€25mg245,00€50mg354,00€100mg533,00€1mL*10mM (DMSO)92,00€14-Deoxy-11,12-didehydroandrographolide
CAS:14-Deoxy-11,12-didehydroandrographolide (AP10) has hypotensive, anti-inflammatory, anti-asthma, and anti-cancer actions. It can inhibit NF-κB activation.Fórmula:C20H28O4Pureza:98.55% - 99.93%Forma y color:SolidPeso molecular:332.43Ref: TM-TQ0185
1mg69,00€5mg187,00€10mg274,00€25mg465,00€50mg677,00€100mg938,00€500mg1.882,00€1mL*10mM (DMSO)145,00€SP-100030
CAS:SP-100030: Strong NF-κB/AP-1 inhibitor, IC50=50 nM. Reduces IL-2, IL-8, TNF-alpha, and murine CIA.Fórmula:C14H5ClF9N3OPureza:99.57%Forma y color:SolidPeso molecular:437.65Ref: TM-T24816
1mg35,00€5mg73,00€10mg104,00€25mg243,00€50mg378,00€100mg542,00€500mgA consultar1mL*10mM (DMSO)82,00€RIPK1-IN-25
RIPK1-IN-25 (WL8) is a RIPK1 inhibitor with blood-brain barrier permeability, displaying an EC50 of 19.9 nM and a Kd of 25 nM. It is utilized in the research of neurodegenerative diseases.Forma y color:Odour SolidGanoderic acid H
CAS:Ganoderic acid H inhibits AP-1/NF-κB, suppressing uPA to exert antitumor effects.Fórmula:C32H44O9Pureza:95% - 97.14%Forma y color:SolidPeso molecular:572.69Galloylpaeoniflorin
CAS:Galloylpaeoniflorin (6'-O-Galloyl paeoniflorin) may be developed as a cytoprotector against ROS-mediated oxidative stress.Fórmula:C30H32O15Pureza:97.1%Forma y color:SolidPeso molecular:632.57Necrostatin 2 racemate
CAS:Necrostatin 2 racemate (Necrostatin-2 racemate) is an potent and specific inhibitor of RIPK1.Fórmula:C13H12ClN3O2Pureza:98% - 99.50%Forma y color:SolidPeso molecular:277.71Ref: TM-T7504
1mg65,00€5mg107,00€10mg169,00€25mg305,00€50mg527,00€100mg743,00€500mg1.510,00€1mL*10mM (DMSO)140,00€Bortezomib
CAS:Bortezomib (LDP 341) is a 20S proteasome inhibitor (Ki=0.6 nM) that is reversible and selective.Fórmula:C19H25BN4O4Pureza:100% - 99.97%Forma y color:Yellow SolidPeso molecular:384.24Ref: TM-T2399
5mg52,00€10mg64,00€25mg80,00€50mg96,00€100mg144,00€200mg225,00€500mg373,00€1mL*10mM (DMSO)52,00€
