NF-κB
El factor nuclear kappa-light-chain-enhancer de células B activadas (NF-κB) es un factor de transcripción que regula la expresión de genes involucrados en respuestas inmunitarias, inflamación, supervivencia celular y proliferación. El NF-κB se activa en respuesta a varios estímulos, incluidos citocinas, patógenos y señales de estrés. La desregulación de la señalización de NF-κB está asociada con enfermedades inflamatorias crónicas, cáncer y trastornos autoinmunes. En CymitQuimica, ofrecemos una selección integral de moduladores de la vía NF-κB para apoyar su investigación en inflamación, oncología y regulación inmunitaria.
Productos de "NF-κB"
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SZM-1209
CAS:SZM-1209 is a potent and specific RIPK1 inhibitor with oral activity, displaying a dissociation constant (Kd) of 85 nM.Fórmula:C31H29F5N4O5S2Pureza:98%Forma y color:SolidPeso molecular:696.71Penehyclidine hydrochloride
CAS:Penehyclidine hydrochloride: M1/M3 antagonist, activates NF-κB, anti-inflammatory, anticholinergic.Fórmula:C20H30ClNO2Pureza:99.7%Forma y color:SolidPeso molecular:351.91Isophysalin A
CAS:Isophysalin A exhibits anti-inflammatory activitiy, it exhibits conjugating abilities with glutathione and also shows significant nitric oxide (NO) productionFórmula:C28H30O10Pureza:98%Forma y color:SolidPeso molecular:526.53NT-0796
CAS:NT-0796 is an inflammasome NLRP3 inhibitor that inhibits NLRP3 activation.NT-0796 is a potential NDT-19795 delivery vector.Fórmula:C23H27N3O4Pureza:99.67%Forma y color:SolidPeso molecular:409.48DTP3
CAS:DTP3 is a selective MKK7/GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway.Fórmula:C26H35N7O5Forma y color:SolidPeso molecular:525.6IMD-vanillin
CAS:IMD-vanillin is a novel compound characterized as an imidazoquinolinone-derived dimer with NF-κB immunomodulatory properties.Fórmula:C37H45N7O4Pureza:98%Forma y color:SolidPeso molecular:651.8Ethacrynic acid
CAS:Ethacrynic acid (Edecrin) 是谷胱甘肽 S-转移酶抑制剂,也是NF-κB 信号传导途径的有效抑制剂,并且还调节白三烯的形成。它还可抑制 L 型电压依赖性和储存操作的钙通道,从而导致气道平滑肌细胞松弛。它是利尿剂,具有抗炎特性,可减轻类维生素 A 诱导的小鼠耳部水肿。Fórmula:C13H12Cl2O4Pureza:100% - 99.15%Forma y color:Crystals Physical Description White Solid (Ntp 1992)Peso molecular:303.14Zharp1-211
CAS:Zharp1-211 is a RIPK3 inhibitor,reduces JAK/ stat1-mediated chemokines and MHC class II molecules in IECs, (GVHD) for gastrointestinal inflammation.Fórmula:C24H25N5O4Pureza:99.71%Forma y color:SolidPeso molecular:447.494-Hydroxychalcone
CAS:4-Hydroxychalcone (P-Cinnamoylphenol) attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice.Fórmula:C15H12O2Pureza:99.75%Forma y color:Yellow PowderPeso molecular:224.25Forsythoside B
CAS:Forsythoside B inhibits LPS, NF-κB, inflammation, offers neuroprotection, reduces ischemia injury, and has antioxidant and antisepsis effects.Fórmula:C34H44O19Pureza:98% - 98.78%Forma y color:SolidPeso molecular:756.7GSK-843
CAS:GSK-843 (GSK'843) is a RIP3 inhibitor with analgesic activity, inhibits RIP3 expression, and can be used as an adjunctive treatment for inflammation.Fórmula:C19H15N5S2Pureza:99.18%Forma y color:SolidPeso molecular:377.49Sanggenon C
CAS:Sanggenon C inhibits NF-κB activity, the expression of inducible nitric oxide synthase, tumor necrosis factor-α-stimulated cell adhesion and the expression of vascular cell adhesion molecule-1 in RAW264.7 cells. Cost-effective and quality-assured.Fórmula:C40H36O12Pureza:97.76% - 98.54%Forma y color:SolidPeso molecular:708.71Lidocaine
CAS:Lidocaine, an amide local anesthetic, reduces pain and inflammation by dampening ICAM-1, cytokines, and neutrophil influx.Fórmula:C14H22N2OPureza:98.35% - 99.95%Forma y color:Needles From Benzene Or Alcohol SolidPeso molecular:234.344-O-Methyl honokiol
CAS:4-O-Methyl honokiol (4-O-Methylhonokiol), derived from Magnolia officinalis and Magnolia officinalis, is a PPARγ agonist with antiangiogenic properties.Fórmula:C19H20O2Pureza:99.31%Forma y color:SolidPeso molecular:280.36Ref: TM-T10153
1mg57,00€5mg120,00€10mg187,00€25mg354,00€50mg528,00€100mg758,00€500mg1.568,00€1mL*10mM (DMSO)131,00€IKK 16
CAS:IKK 16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.Fórmula:C28H29N5OSPureza:98.76% - 99.61%Forma y color:SolidPeso molecular:483.63Ref: TM-T6176
1mg40,00€2mg52,00€5mg88,00€10mg139,00€25mg245,00€50mg406,00€100mg607,00€200mg845,00€1mL*10mM (DMSO)87,00€CA-4948
CAS:CA-4948 (Emavusertib) is a potent IRAK4/FLT3 inhibtor. CA-4948 with anti-tumor activity.Fórmula:C24H25N7O5Pureza:99.62%Forma y color:SolidPeso molecular:491.5Ref: TM-T9027
1mg35,00€2mg52,00€5mg77,00€10mg87,00€25mg170,00€50mg311,00€100mg535,00€1mL*10mM (DMSO)84,00€Lobeglitazone Sulfate
CAS:Lobeglitazone Sulfate (CKD-501) is an anti-inflammatory thiazolidinedione that prevents NLRP3 inflammasome activation and is used in T2DM research.Fórmula:C24H26N4O9S2Pureza:98.69%Forma y color:SolidPeso molecular:578.61Laquinimod
CAS:Laquinimod (LAQ) is an effective immunomodulator, which is currently under development in phase III trials for the treatment of multiple sclerosis as an oralFórmula:C19H17ClN2O3Pureza:98.16% - 98.84%Forma y color:SolidPeso molecular:356.8RI-962
CAS:RI-962 is a potent and selective inhibitor of RIPK1 that protects cells from necrotic apoptosis by inhibiting RIPK1, RIPK3, and MLKL phosphorylation.Fórmula:C28H28N6O2Pureza:99.39%Forma y color:SoildPeso molecular:480.56Berbamine
CAS:Berbamine is a natural product extracted from Phellodendron amurense.Fórmula:C37H40N2O6Pureza:98.92% - 99.64%Forma y color:White Crystal PowderPeso molecular:608.72
