NF-κB
El factor nuclear kappa-light-chain-enhancer de células B activadas (NF-κB) es un factor de transcripción que regula la expresión de genes involucrados en respuestas inmunitarias, inflamación, supervivencia celular y proliferación. El NF-κB se activa en respuesta a varios estímulos, incluidos citocinas, patógenos y señales de estrés. La desregulación de la señalización de NF-κB está asociada con enfermedades inflamatorias crónicas, cáncer y trastornos autoinmunes. En CymitQuimica, ofrecemos una selección integral de moduladores de la vía NF-κB para apoyar su investigación en inflamación, oncología y regulación inmunitaria.
Productos de "NF-κB"
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Tyloxapol
CAS:Tyloxapol (Triton WR1339) is a non-ionic liquid polymer used as a surfactant.Fórmula:C70H124O13Pureza:polymer - polymerForma y color:Clear Light Yellow Viscous LiquidPeso molecular:137.18Ref: TM-T6S1371
1mg52,00€5mg97,00€10mg140,00€25mg274,00€50mg411,00€100mg597,00€500mg1.225,00€1mL*10mM (DMSO)105,00€Demethyleneberberine
CAS:Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria eitherFórmula:C19H18NO4Pureza:98.08% - 99.18%Forma y color:SolidPeso molecular:324.35Theaflavin 3,3'-digallate
CAS:Theaflavin 3,3'-digallate (8-Gingerol) , a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancerFórmula:C43H32O20Pureza:98.71% - 99.86%Forma y color:SolidPeso molecular:868.7Ocadusertib
CAS:Ocadusertib is an effective inhibitor of the serine/threonine kinase receptor-interacting protein kinase 1 (RIPK1).Fórmula:C25H25N5O4Forma y color:SolidPeso molecular:459.50Eclitasertib
CAS:Eclitasertib is a potent inhibitor of receptor-interacting protein kinase 1 (RIPK1, IC50 of <1 µΜ).Fórmula:C19H18N6O3Pureza:99.82%Forma y color:SolidPeso molecular:378.38Ref: TM-T9702
1mg106,00€2mg150,00€5mg227,00€10mg359,00€25mg652,00€50mg905,00€100mg1.293,00€1mL*10mM (DMSO)250,00€BX795
CAS:BX795 selectively inhibits PDK1 (IC50: 6 nM), 140x over PKA, 1600x over PKC, 100x over GSK3β in cell-free assays.Fórmula:C23H26IN7O2SPureza:98% - 99.57%Forma y color:SolidPeso molecular:591.47Ref: TM-T1830
5mg59,00€10mg97,00€25mg210,00€50mg343,00€100mg513,00€200mg740,00€500mg1.121,00€1mL*10mM (DMSO)88,00€CL075
CAS:CL075 (3M002) is a selective TLR8 agonist.CL075 has immunomodulatory activity by triggering the MyD88-dependent signaling pathway, activating NF-κB and IRF7 toFórmula:C13H13N3SPureza:99.25%Forma y color:SolidPeso molecular:243.33Flaconitine
CAS:Flaconitine (Acetylaconitine) is an NF-κB inhibitor and an alkaloid.Fórmula:C36H49NO12Pureza:98% - 99.84%Forma y color:SolidPeso molecular:687.77Flavanomarein
CAS:Flavanomarein: Antioxidant with radical scavenging, lipid peroxidation inhibition, and lipid-lowering in HepG2 cells.Fórmula:C21H22O11Pureza:97.53% - 98.63%Forma y color:SolidPeso molecular:450.39Ginsenoside Re
CAS:Ginsenoside Re (Ginsenoside B2) may have properties that inhibit or prevent the growth of tumors.Fórmula:C48H82O18Pureza:100% - 99.78%Forma y color:White PowderPeso molecular:947.15B022
CAS:B022 is an NF-κB-induced kinase (NIK) inhibitor that protects the liver from inflammation and injury caused by oxidative stress and toxins.Fórmula:C19H16ClN5OSPureza:99.74%Forma y color:SolidPeso molecular:397.88Mitogen-activated protein kinase 1
CAS:Mitogen-activated protein kinase 1 (MAPK1) activates the p38/NF-κB pathway and regulates cellular processes in sepsis-associated diseases.Pureza:98%Forma y color:SolidRIPK1-IN-9
CAS:RIPK1-IN-9, a potent dihydronaphthone, selectively inhibits RIPK1 with IC50 of 2 nM (U937) and 1.3 nM (L929).Fórmula:C26H25FN6O2Pureza:98.7%Forma y color:SolidPeso molecular:472.51Ref: TM-T63055
1mg205,00€5mg495,00€10mg677,00€25mg1.008,00€50mg1.349,00€100mg1.833,00€200mg2.452,00€1mL*10mM (DMSO)568,00€Gossypin
CAS:Gossypin exhibits multiple medicinal properties and inhibits NF-kappaB, reducing inflammation, cancer growth, and angiogenesis.Fórmula:C21H20O13Pureza:97.57% - 98.97%Forma y color:SolidPeso molecular:480.38NLRP3-IN-10
CAS:NLRP3-IN-10 (ZVN26391) is a strong NLRP3 inhibitor, IC50 251.1 nM, that reduces IL-1β and ASC speck, hindering inflammasome activation.Fórmula:C17H14BrFO3Pureza:99.63%Forma y color:SolidPeso molecular:365.19Ref: TM-T61392
5mg47,00€10mg70,00€25mg126,00€50mg187,00€100mg311,00€200mg465,00€1mL*10mM (DMSO)65,00€2,4-Diamino-6-hydroxypyrimidine
CAS:2,4-Diamino-6-hydroxypyrimidine (DAHP) (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesisFórmula:C4H6N4OPureza:99.82%Forma y color:White Solid CrystalsPeso molecular:126.12NLRP3-IN-11
CAS:NLRP3-IN-11 is an NLRP3 protein inhibitor with potential anti-inflammatory activity.NLRP3-IN-11 can be used in the study of atherosclerosis and parkinsonism.Fórmula:C17H17ClN4O2Pureza:100%Forma y color:SolidPeso molecular:344.8GSK2983559 active metabolite
CAS:GSK2983559 active metabolite (RIPK2-IN-1) is a potent, selective receptor-interacting protein-2 (RIP2) kinase inhibitor.Fórmula:C21H22N4O4S2Pureza:97.07% - 98.48%Forma y color:SolidPeso molecular:458.55Convallatoxin
CAS:Convallatoxin is a natural product.Fórmula:C29H42O10Pureza:99.27%Forma y color:Prisms From Methanol + Ether SolidPeso molecular:550.64
