p38 MAPK
Las p38 MAPK son un subgrupo de MAPK que responden a señales de estrés y están involucradas en la regulación de la inflamación, la diferenciación celular, la apoptosis y la autofagia. La señalización de p38 MAPK es crucial en las respuestas inmunitarias y está implicada en varias enfermedades, incluidas las condiciones inflamatorias crónicas, el cáncer y los trastornos neurodegenerativos. En CymitQuimica, ofrecemos una gama completa de inhibidores y moduladores de p38 MAPK para apoyar su investigación en inflamación, respuesta al estrés y desarrollo terapéutico.
Productos de "p38 MAPK"
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Paris saponin VII
CAS:Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.Fórmula:C51H82O21Pureza:99.51% - 99.63%Forma y color:SolidPeso molecular:1031.18VX-702
CAS:VX-702: selective p38α MAPK inhibitor, potent anti-cytokine for rheumatoid arthritis.Fórmula:C19H12F4N4O2Pureza:100% - 99%Forma y color:SolidPeso molecular:404.32Emprumapimod
CAS:Emprumapimod, an oral p38α MAPK inhibitor, targets RPMI-8226 cells, curbs LPS-induced IL-6; IC50: 100 pM; for cardiomyopathy, acute pain.Fórmula:C24H29F2N5O3Pureza:100% - 99.21%Forma y color:SolidPeso molecular:473.52MAPK13-IN-1
CAS:MAPK13-IN-1 is a potent MAPK13 (p38δ) inhibitor (IC50: 620 nM).Fórmula:C20H23N5O2Pureza:99.55%Forma y color:SolidPeso molecular:365.43Ref: TM-T11943
1mg99,00€2mg144,00€5mg235,00€10mg354,00€25mg610,00€50mg885,00€100mg1.293,00€500mg2.585,00€1mL*10mM (DMSO)259,00€Afatinib Dimaleate
CAS:Afatinib Dimaleate (BIBW 2992MA2) is an orally bioavailable anilino-quinazoline derivative and inhibitor of the EGFR family, with antineoplastic activity.Fórmula:C32H33ClFN5O11Pureza:100% - 98.11%Forma y color:SolidPeso molecular:718.08Ref: TM-T1773
1g467,00€5mg40,00€10mg59,00€25mg87,00€50mg107,00€100mg140,00€200mg188,00€500mg313,00€1mL*10mM (DMSO)66,00€Afatinib
CAS:Afatinib (BIBW 2992) is an irreversible and orally EGFR family inhibitor that inhibits EGFR and HER2. Afatinib has antitumor activity. Cost effective and quality assured.Fórmula:C24H25ClFN5O3Pureza:97.56% - 99.9%Forma y color:Off-White SolidPeso molecular:485.94Ref: TM-T21312
5mg35,00€10mg51,00€25mg86,00€50mg115,00€100mg144,00€200mg177,00€500mg300,00€1mL*10mM (DMSO)52,00€Nitidine chloride
CAS:1.Fórmula:C21H18ClNO4Pureza:96.59% - 98.91%Forma y color:SolidPeso molecular:383.82BI-3406
CAS:BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.Fórmula:C23H25F3N4O3Pureza:99.20% - 99.66%Forma y color:SolidPeso molecular:462.46Ref: TM-T12979
1mg73,00€5mg160,00€10mg250,00€25mg464,00€50mg663,00€100mg919,00€500mg1.833,00€1mL*10mM (DMSO)170,00€AMG 900
CAS:AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM.Fórmula:C28H21N7OSPureza:98.35% - 98.9%Forma y color:SolidPeso molecular:503.58Ref: TM-T6380
1mg52,00€5mg97,00€10mg166,00€25mg303,00€50mg467,00€100mg682,00€500mg1.415,00€1mL*10mM (DMSO)105,00€Akt/NF-κB/MAPK-IN-1
Akt/NF-κB/MAPK-IN-1 (compound 2m) serves as a potent, orally active inhibitor targeting NO with an IC50 of 7.70 μM and demonstrates low toxicity.Fórmula:C38H56N2O4Pureza:98%Forma y color:SolidPeso molecular:604.86SB 202190 hydrochloride
CAS:SB 202190 hydrochloride is a p38 MAPK inhibitor that inhibits p38α and p38β2 with selective, cell-permeable, and antitumor ,differentiation to cardiomyocytes.Fórmula:C20H15ClFN3OPureza:99.99%Forma y color:SolidPeso molecular:367.8Ref: TM-T35592
2mg49,00€5mg66,00€10mg90,00€25mg145,00€50mg207,00€100mg309,00€200mg459,00€1mL*10mM (DMSO)71,00€Dehydrocorydaline chloride
CAS:Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid with anti-inflammatory and anti-cancer activity. Can improve the activation of p38 MAPK.Fórmula:C22H24ClNO4Pureza:99.53%Forma y color:SolidPeso molecular:401.88Ref: TM-T10990
1mg58,00€5mg111,00€10mg160,00€25mg264,00€50mg396,00€100mg563,00€1mL*10mM (DMSO)124,00€PDE4-IN-26
PDE4-IN-26 (Compound A5) is an orally active, highly selective inhibitor of PDE4. It exhibits anti-inflammatory properties by inhibiting p38 MAPK phosphorylation. In mouse models of acute lung injury and chronic obstructive pulmonary disease, PDE4-IN-26 reduces lung inflammation, damage, and fibrosis, while promoting sputum secretion and alleviating cough. It is useful for researching lung injury-related diseases.Fórmula:C22H18F2N4O3SForma y color:SolidPeso molecular:456.47Wortmannin
CAS:Producto controladoApplications Wortmannin is a phosphatidylinositol 3 kinase (PI3K) inhibitor. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Liberman R., et. al.: J. Biol. Chem., 289, 1355 (2014)Fórmula:C23H24O8Forma y color:White To Light YellowPeso molecular:428.43PS-166276
CAS:PS-166276 is a potent p38 inhibitor with low cytotoxicity. It exhibits an IC50 value of 28 nM against p38 kinase and an IC50 of 170 nM in the THP-1 TNFα assay.Fórmula:C20H30N8OForma y color:SolidPeso molecular:398.51p38α inhibitor 4
CAS:p38α inhibitor 4 is a selective MAPK p38α inhibitor, which is used to study diabetes, pain and chronic inflammation.Fórmula:C14H7F6N3OPureza:99.79%Forma y color:SolidPeso molecular:347.215AZD7624
CAS:AZD7624 is an p38 inhibitor. It has potent anti-inflammatory activity.Fórmula:C27H30FN5O3Pureza:99.37%Forma y color:SolidPeso molecular:491.56Ref: TM-T14381
1mg73,00€5mg160,00€10mg250,00€25mg507,00€50mg737,00€100mg1.026,00€1mL*10mM (DMSO)170,00€OVA-E1 peptide TFA
CAS:OVA-E1 peptide TFA activates the p38 and JNK cascades similarly in mutant and wild-type thymocytes.Fórmula:C49H77F3N10O16Pureza:98%Forma y color:SolidPeso molecular:1119.19
