Canal TRP / TRPV
Los canales TRP (Receptor Potencial Transitorio), incluida la subfamilia TRPV, son un grupo de canales iónicos involucrados en diversos procesos sensoriales, como la sensación de temperatura, la percepción del dolor y la osmorregulación. Los canales TRP están ampliamente expresados en diferentes tejidos y desempeñan un papel en las respuestas fisiológicas a estímulos ambientales. Los canales TRPV, en particular, están involucrados en la detección de cambios de temperatura y están implicados en condiciones como el dolor crónico, la inflamación y el cáncer. En CymitQuimica, ofrecemos una gama completa de moduladores de canales TRP/TRPV para apoyar su investigación en biología sensorial, manejo del dolor y transducción de señales.
Productos de "Canal TRP / TRPV"
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GSK2193874
CAS:GSK2193874 was identified as a selective, orally active TRPV4 blocker.Fórmula:C37H38BrF3N4OPureza:98.79% - ≥95%Forma y color:SolidPeso molecular:691.62Ref: TM-T5640
1mg43,00€2mg57,00€5mg81,00€10mg127,00€25mg246,00€50mg404,00€100mg602,00€1mL*10mM (DMSO)111,00€AMTB hydrochloride
CAS:AMTB HCl: Novel TRPM8 blocker, relieves pain, treats urinary issues, moderates bladder reflexes in rats.Fórmula:C23H27ClN2O2SPureza:99.08%Forma y color:SolidPeso molecular:430.99Ref: TM-T19723
1mg37,00€5mg79,00€10mg126,00€25mg264,00€50mg449,00€100mg662,00€200mg939,00€1mL*10mM (DMSO)92,00€Pico145
CAS:Pico145 (HC-608) is a remarkable inhibitor of TRPC1/4/5 channels.Fórmula:C23H20ClF3N4O5Pureza:99.06%Forma y color:SolidPeso molecular:524.88Ref: TM-T16532
1mg77,00€5mg165,00€10mg240,00€25mg408,00€50mg562,00€100mg800,00€200mg1.074,00€1mL*10mM (DMSO)187,00€AMG 333
CAS:AMG 333 is TRPM8 antagonist with an IC50 of 13 nM,a Clinical Candidate for the Treatment of Migraine.Fórmula:C20H12F5N3O4Pureza:99.95%Forma y color:SolidPeso molecular:453.32SB-705498
CAS:SB705498 is a TRPV1 antagonist for hTRPV1. SB-705498 has been investigated for the treatment of Rhinitis, Chronic Cough, and Non-allergic Rhinitis.Fórmula:C17H16BrF3N4OPureza:99.16% - ≥95%Forma y color:SolidPeso molecular:429.23EIPA hydrochloride
CAS:EIPA hydrochloride also inhibits Na+/H+-exchanger (NHE) and macropinocytosisEIPA hydrochloride (L593754 hydrochloride) is a TRPP3 channel inhibitor with an IC50 of 10.5 μM.Fórmula:C11H19Cl2N7OPureza:98%Forma y color:SolidPeso molecular:336.22GFB-8438
CAS:GFB-8438 is a potent and subtype selective inhibitor of TRPC5(IC50s of 0.18 and 0.29 μM of hTRPC5 and hTRPC4, respectively).Fórmula:C16H14ClF3N4O2Pureza:99.58%Forma y color:SolidPeso molecular:386.76Ref: TM-T11394
2mg35,00€5mg52,00€10mg81,00€25mg117,00€50mg170,00€100mg250,00€200mg369,00€1mL*10mM (DMSO)58,00€AMG-0347
CAS:AMG-0347 inhibits TRPA1 ion channels in sensory neurons, blocking pain perception.Fórmula:C24H26F3N3O2Pureza:99.7%Forma y color:SolidPeso molecular:445.48Ref: TM-T29968
1mg226,00€5mg552,00€10mg735,00€25mg1.111,00€50mg1.491,00€100mg2.005,00€200mg2.707,00€1mL*10mM (DMSO)567,00€ML-SA1
CAS:ML-SA1 (Mucolipin synthetic agonist 1) is a selective TRPML agonist, inhibits DENV2 and ZIKV by promoting lysosomal acidification and protease activity.Fórmula:C22H22N2O3Pureza:99.71%Forma y color:SolidPeso molecular:362.42Ref: TM-T23004
2mg37,00€5mg51,00€10mg81,00€25mg150,00€50mg244,00€100mg364,00€200mg550,00€1mL*10mM (DMSO)58,00€JT010
CAS:JT010 is an effective agonist of TRPA1 (EC50 = 0.65 nM).Fórmula:C16H19ClN2O3SPureza:98.5%Forma y color:SolidPeso molecular:354.85M8-B Hydrochloride
CAS:M8-B Hydrochloride is a selective transient receptor potential melastatin-8 (TRPM8) channel antagonist.Fórmula:C22H25ClN2O3SPureza:99.33%Forma y color:SolidPeso molecular:432.96Ref: TM-T8442
2mg35,00€5mg52,00€10mg74,00€25mg145,00€50mg226,00€100mg335,00€200mg469,00€1mL*10mM (DMSO)64,00€ML329
CAS:ML329 is a small molecule inhibitor of MITF, inhibiting TRPM-1 promoter activity.Fórmula:C16H12N2O4SPureza:98.96%Forma y color:SolidPeso molecular:328.34Ref: TM-T4028
1mg52,00€2mg73,00€5mg115,00€10mg187,00€25mg424,00€50mg627,00€100mg893,00€1mL*10mM (DMSO)118,00€TRPM4-IN-1
CAS:TRPM4-IN-1 (4-chloro-2-(2-(2-chlorophenoxy)acetamido)benzoic acid) is a potent and selective inhibitor of TRPM4 with an IC50 of 1.5 μM.Fórmula:C15H11Cl2NO4Pureza:97.22%Forma y color:SolidPeso molecular:340.16TRPM8 antagonist 3
CAS:TRPM8 antagonist 3 is a blocker of TRPM8 (IC50 = 11 nM).Fórmula:C13H12N2O4SPureza:99.25%Forma y color:SolidPeso molecular:292.31Ref: TM-T9709
1mg62,00€5mg135,00€10mg202,00€25mg335,00€50mg490,00€100mg672,00€200mg905,00€1mL*10mM (DMSO)149,00€A-1165442
CAS:A-1165442 is a competitive TRPV1 antagonist. For human TRPV, the IC50 values is 9 nM.Fórmula:C22H20ClF2N3O2Forma y color:SolidPeso molecular:431.86ML204 hydrochloride
CAS:ML204 hydrochloride (ML204 HCl) is a TRPC4/TRPC5 channel antagonist.Fórmula:C15H19ClN2Forma y color:SolidPeso molecular:262.78HC-030031
CAS:HC-030031 (TOSLAB 829227) is a potent TRPA1 inhibitor, which antagonizes AITC- and formalin-evoked calcium influx with IC50s of 6.2 and 5.3 μM, respectively.Fórmula:C18H21N5O3Pureza:99.69% - ≥95%Forma y color:SolidPeso molecular:355.39Optovin
CAS:Optovin is a TRPA1 activator, which is reversibly photoactivated.Fórmula:C15H13N3OS2Pureza:100.00% - 99.16%Forma y color:SolidPeso molecular:315.41Ref: TM-T6617
1mg40,00€2mg51,00€5mg81,00€10mg97,00€25mg188,00€50mg314,00€100mg563,00€200mg687,00€1mL*10mM (DMSO)86,00€TRPM4-IN-2
CAS:NBA, or TRPM4-IN-2, is a potent TRPM4 inhibitor with IC50 of 0.16 μM, used in prostate and colorectal cancer research.Fórmula:C19H14ClNO4Pureza:99.21%Forma y color:SolidPeso molecular:355.77(S)-ABT 102
CAS:N-[(1S)-1H-inden-1-yl]-N'-indazol-4-ylurea is a strong TRPV1 blocker with a 123 nM IC50 against capsaicin.Fórmula:C21H24N4OPureza:99.41% - 99.78%Forma y color:SoildPeso molecular:348.44Ref: TM-T29522L
1mg77,00€5mg158,00€10mg225,00€25mg338,00€50mg472,00€100mg645,00€200mg868,00€1mL*10mM (DMSO)162,00€
