Canal de sodio
Los canales de sodio son proteínas de membrana esenciales que permiten el paso de iones de sodio (Na+) a través de la membrana celular, generando y propagando señales eléctricas en neuronas, células musculares y otros tejidos excitables. Estos canales son vitales para la iniciación y conducción de potenciales de acción, lo que los hace cruciales en procesos como la transmisión de impulsos nerviosos, la contracción muscular y la función cardíaca. La desregulación de los canales de sodio puede llevar a trastornos neurológicos, arritmias y condiciones de dolor crónico. En CymitQuimica, ofrecemos una variedad de moduladores de canales de sodio para apoyar su investigación en neurobiología, cardiología y manejo del dolor.
Productos de "Canal de sodio"
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Halofuginone
CAS:Halofuginone (RU-19110) inhibits prolyl-tRNA synthetase (Ki=18.3 nM), down-regulates Smad3, and blocks TGF-β at 10 ng/ml.Fórmula:C16H17BrClN3O3Pureza:97.67%Forma y color:Off-White SolidPeso molecular:414.68Bupivacaine N-Oxide Hydrochloride Salt
CAS:Producto controladoApplications The N-oxide of the local anesthetic Bupivacaine (B689546). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the packageFórmula:C18H29ClN2O2Forma y color:White To BeigePeso molecular:340.89Tizolemide
CAS:Tizolemide, a sulfonamide diuretic compound with alkaline properties, is cleared through the tubular transport system. It induces changes in the passive transport components across the basolateral membrane of isolated frog skin.Fórmula:C11H14ClN3O3S2Forma y color:SolidPeso molecular:335.83Vinpocetine
CAS:Vinpocetine (RGH-4405) is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).Fórmula:C22H26N2O2Pureza:99.85% - 99.98%Forma y color:White Crystalline SolidPeso molecular:350.45Metaflumizone
CAS:Applications Metaflumizone is a semicarbazone insecticide that works by blocking sodium channel in target insects resulting in paralyzation associated with blocking nerve activity. Metaflumizone is useful as a heartworm control treatment. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Zhang, Zhe,, et al.: J. Integrat. Agri. 11, 1145 (2012); Kuhn, D., et al.: Modern. Crop. Protect. Compound., 3, 1273 (2012);Fórmula:C24H16F6N4O2Forma y color:WhitePeso molecular:506.40KR-32568
CAS:KR-32568 is a sodium/hydrogen exchanger 1 (NHE-1) inhibitor (IC50: 230 nM).Fórmula:C13H12FN3O2Pureza:99.89%Forma y color:SolidPeso molecular:261.25Ref: TM-T36569
1mg46,00€5mg92,00€10mg145,00€25mg284,00€50mg411,00€100mg562,00€200mg743,00€1mL*10mM (DMSO)95,00€Capsazepine
CAS:Producto controladoApplications A selective vanilloid receptor antagonist (Ki=3.2uM) References Dickenson and Dray: Br. J. Pharmacol., 104, 1045 (1991), Kwak, et al.: Neuroscience, 86, 619 (1998), Szallasi and Blumberg: Pharmacol. Rev., 51, 159 (999)Fórmula:C19H21ClN2O2SForma y color:NeatPeso molecular:376.90QX-314 chloride
CAS:QX-314 chloride is a membrane-impermeable permanently charged blocker of sodium channel.Fórmula:C16H27ClN2OPureza:99.73%Forma y color:SolidPeso molecular:298.85Lubeluzole dihydrochloride
CAS:Lubeluzole (dihydrochloride) acts as a neuroprotective agent by blocking neuronal voltage-gated sodium channels and also affects cardiac sodium channels, exhibiting both tonic and blocking effects. This compound is considered promising in the research of antiarrhythmic agents.Fórmula:C22H27Cl2F2N3O2SForma y color:SolidPeso molecular:506.44Propafenone hydrochloride
CAS:Propafenone hydrochloride (Arythmol8) is a classic anti-arrhythmic medication, which treats illnesses associated with rapid heartbeats such as atrial.Fórmula:C21H27NO3·HClPureza:99.67%Forma y color:White SolidPeso molecular:377.9Prilocaine-D7 Hydrochloride
CAS:Producto controladoApplications Labelled Prilocaine (P725000). Prilocaine is a local anesthetic of the amino amide type. Prilocaine is often used in dentistry. Prilocaine is also often combined with lidocaine as a preparation for dermal anesthesia (lidocaine/prilocaine or EMLA), for treatment of conditions like paresthesia. References Caliaro, G., et al.: J. Pharm. Biomed. Anal., 26, 427 (2001), Ulmeanu, S., et al.: Pharm. Res., 20, 1317 (2003),Fórmula:C13H14D7ClN2OForma y color:NeatPeso molecular:263.81Phenazopyridine hydrochloride
CAS:Phenazopyridine HCl, an oral urinary analgesic, may cause nausea, anemia, and liver/kidney toxicity. Possibly carcinogenic.Fórmula:C11H12ClN5Pureza:99.27%Forma y color:Brownish-Yellow Crystals Aqueous Solutions Are Yellow To Brick-Red And Slightly Acidic; They May Be Stabilized By The AdditionPeso molecular:249.7Silperisone HCl
CAS:Silperisone HCl is a muscle relaxant and vasodilator, treating myoclonus, hypertonia, dystonia, and myospasm by blocking Na+ and Ca2+ channels.Fórmula:C15H25ClFNSiPureza:100%Forma y color:SolidPeso molecular:301.9Bupivacaine-d9 N-Oxide
CAS:Producto controladoStability Very Hygroscopic Applications The labelled N-oxide of the local anesthetic Bupivacaine (B689546).Fórmula:C18H19D9N2O2Forma y color:NeatPeso molecular:313.48ICA-121431
CAS:ICA-121431: a potent Nav1.7 inhibitor (IC50=19 nM for rat), minimal effect on human Nav1.5/Nav1.7.Fórmula:C23H19N3O3S2Pureza:98%Forma y color:SolidPeso molecular:449.55Dimethocaine Hydrochloride
CAS:Producto controladoApplications A local anesthetic with stimulant properties. Studies have shown its potency to be about half that of Cocaine (C633500). References Wppdward, J.J. et al.: Eur. J. Pharmacol., 277, 7 (1995); Rigon, A.R. et al.: Psychopharmacol., 127, 323 (1996); Wilcox, K.M. et al.: Synapse, 58, 220 (2005);Fórmula:C16H26N2O2·ClHForma y color:White To BeigePeso molecular:314.85Soraprazan
CAS:BS3 Crosslinker (Bis(sulfosuccinimidyl)suberate) is an ADC linker that can be used to synthesize antibody-coupled active molecules.Fórmula:C21H25N3O3Pureza:97.69% - 99.84%Forma y color:SolidPeso molecular:367.44Gitoxin
CAS:Producto controladoStability Hygroscopic Applications Gitoxin acts as in inhibitor of the sodium and potassium ion channels, interfering with ATPase activity and used in cancer treatment as a growth inhibitor. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Colovic, M. et al.: Russ. J. Phys. Chem. A., 83, 1602 (2009); Banuls, L. et al.: Mol. Canc., 12, 33 (2013);Fórmula:C41H64O14Forma y color:NeatPeso molecular:780.94Mepivacaine Hydrochloride
CAS:Producto controladoApplications An anti-inflammatory and analgesic agent. Anesthetic (local). Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Reynolds, et al.: Br. J. Anaesth., 43, 33 (1971), Tullar, et al.: J. Med. Chem., 14, 891 (1971), Aberg, G., et al.: Acta Pharmacol. Toxicol., 31, 273 (1972),Fórmula:C15H22N2O·ClHForma y color:WhitePeso molecular:282.8120(S)-Ginsenoside Rg3
CAS:20(S)-Ginsenoside Rg3 (Rg3) possess an ability to inhibit the lung metastasis of tumor cells via inhibition of the adhesion and invasion of tumor cells.Fórmula:C42H72O13Pureza:100% - 99.93%Forma y color:SolidPeso molecular:785.01
