Canal de sodio
Los canales de sodio son proteínas de membrana esenciales que permiten el paso de iones de sodio (Na+) a través de la membrana celular, generando y propagando señales eléctricas en neuronas, células musculares y otros tejidos excitables. Estos canales son vitales para la iniciación y conducción de potenciales de acción, lo que los hace cruciales en procesos como la transmisión de impulsos nerviosos, la contracción muscular y la función cardíaca. La desregulación de los canales de sodio puede llevar a trastornos neurológicos, arritmias y condiciones de dolor crónico. En CymitQuimica, ofrecemos una variedad de moduladores de canales de sodio para apoyar su investigación en neurobiología, cardiología y manejo del dolor.
Productos de "Canal de sodio"
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Clopamide
CAS:Clopamide (Brinaldix) is a piperidine and sulfamoylbenzamide-based diuretic with thiazide-like diuretic activity.Fórmula:C14H20ClN3O3SPureza:99.21%Forma y color:White To Yellowish Crystalline PowderPeso molecular:345.84NaV1.7 inhibitor-1
CAS:NaV1.7 inhibitor-1, an efficacious inhibitor of voltage-gated sodium channel (NaV) 1.7 (IC50 of 0.6 nM for hNaV1.7).Fórmula:C23H30FNO4SPureza:99.89%Forma y color:SolidPeso molecular:435.55Ref: TM-T12181
1mg104,00€5mg255,00€10mg406,00€25mg700,00€50mg938,00€100mg1.378,00€1mL*10mM (DMSO)280,00€Rufinamide
CAS:Rufinamide (E 2080), a triazole derivative, is used as voltage-gated sodium channel blocker for the treatment of seizure disorders.Fórmula:C10H8F2N4OPureza:99.77% - 99.89%Forma y color:White PowderPeso molecular:238.19Lifarizine FA
Lifarizine FA is a sodium channel blocker used in the treatment of neurological disorders and cardiovascular diseases, study of stroke.Fórmula:C30H34N4O2Pureza:99.87%Forma y color:SolidPeso molecular:482.62Zonisamide-13C2-15N
CAS:Applications Zonisamide-13C2-15N is the labeled analogue of Zonisamide (Z700000), a sulfonamide antiseizure agent; blocks repetitive firing of voltagesensitive sodium channels and reduces voltage-sensitive T-type calcium currents. Heterocyclic methanesulfonide with anticonvulsant properties. The compound is under investigation for potential therapeutic use as an antiepileptic drug. Anticonvulsant. References Masuda, Y., et al.: Arzneim.-Forsch., 30, 477 (1980); Hammond, E.J., et al.: Gen. Pharmacol., 18, 303 (1987); Schmidt, D., et al.: Epilepsy Res., 15, 67 (1993); Sorkin, E.M., et al.: Drugs, 45, 760 (1993)Fórmula:C613C2H8N15NO3SForma y color:Off-White To Light YellowPeso molecular:215.2rac-Kavain-d3
CAS:Producto controladoStability Light and Moisture Sensitive Applications Isotope Labelled analogue of rac-Kavain (K145490), the main kavalactone found in the roots of the kava plant. Kavain is known to exhibit anticonvulsive properties by attenuating vascular smooth muscle contraction through interactions with voltage-dependent sodium and calcium channels. rac-Kavain was shown in recent research to exhibit protective properties on anaerobic glycolysis, ATP content and intracellular calcium and sodium of anoxic brain vesicles. References Gleitz, J., et al: Neuropharmacol., 35, 1743 (1997); Hashimoto, T., et al.: Phytomedicine, 10, 309 (2003); Mulholland, P.J., et al.: Brain. Res., 945, 106 (2002);Fórmula:C14D3H11O3Forma y color:NeatPeso molecular:233.28Vinpocetine
CAS:Producto controladoApplications A derivative of Vincamine with vasodilating activity. Vasodilator (cerebral). References Han, et al.: J. Biol. Chem., 274, 22337 (1999), O’Donnell, et al.: Pharmacol. Biochem. Behav., 63, 185 (1999)Fórmula:C22H26N2O2Forma y color:White To Off-WhitePeso molecular:350.45TC-N 1752
CAS:TC-N 1752 is an orally active inhibitor of Nav1.7 channel with IC50 of 0.17 μM. TC-N 1752 shows analgesic activities.Fórmula:C25H27F3N6O3Pureza:97.87%Forma y color:SolidPeso molecular:516.52Ref: TM-T23439
1mg35,00€5mg80,00€10mg117,00€25mg259,00€50mg383,00€100mg545,00€200mg740,00€1mL*10mM (DMSO)88,00€Ralfinamide mesylate
CAS:Ralfinamide mesylate (FCE-26742A (mesylate)) is an orally available Na+ channel blocker.Fórmula:C18H23FN2O5SPureza:99.83%Forma y color:SolidPeso molecular:398.45Ref: TM-T7547
1mg78,00€5mg170,00€10mg256,00€25mg423,00€50mg562,00€100mg792,00€200mg1.064,00€1mL*10mM (DMSO)259,00€Pentisomide
CAS:Producto controladoApplications Pentisomide is a sodium channel blocker; derivative of disopyramide. Antiarrhythmic (class I). References Kuhlkamp, V., et al.: Int. J. Cardiol., 36, 69 (1992), Yuan, S., et al.: Cardiovasc. Drug Rev., 11, 74 (1993)Fórmula:C19H33N3OForma y color:NeatPeso molecular:319.48Ancistrotecine B
Ancistrotecine B (Compound 2), a Nav1.7 channel inhibitor (IC50: 0.73 μM), has been shown to alleviate inflammatory pain in mice [1].Fórmula:C26H31NO4Pureza:98%Forma y color:SolidPeso molecular:421.535-Tridecanol
CAS:5-Tridecanol blocks ion flux in sodium channels.Fórmula:C13H28OPureza:97.87%Forma y color:SolidPeso molecular:200.362,6-Dichloro-N-(2,6-dimethylphenyl)hexanamide
CAS:Producto controladoApplications 2,6-Dichloro-N-(2,6-dimethylphenyl)hexanamide is an impurity of the local anesthetic Levobupivacaine (B689546).Fórmula:C14H19Cl2NOForma y color:NeatPeso molecular:288.216-Iodoamiloride
CAS:6-Iodoamiloride is a potent inhibitor of acid-sensing ion channel 1 (ASIC1), exhibiting an IC50 value of 88 nM.Fórmula:C6H8IN7OPureza:98%Forma y color:SolidPeso molecular:321.08Sodium ionophore III
CAS:Sodium ionophore III (ETH2120) is a Na+ ionophore suitable for the test of sodium activity in plasma, serum, and blood.Fórmula:C34H52N2O4Pureza:98.2% - 98.54%Forma y color:SolidPeso molecular:552.79Ajmaline
CAS:Ajmaline, a class Ia anti-arrhythmic, diagnoses Brugada syndrome and treats tachycardia; inhibits cardiac Kv1.5/Kv4.3 channels.Fórmula:C20H26N2O2Pureza:99.67% - 99.87%Forma y color:SolidPeso molecular:326.436-Benzoylheteratisine
CAS:6-Benzoylheteratisine (Heteratisan-14-one, 6-(benzoyloxy)-20-ethyl-8-hydroxy-1-methoxy-4-meth) is a Aconitum alkaloid.Fórmula:C29H37NO6Pureza:99.87%Forma y color:SolidPeso molecular:495.61Nicainoprol
CAS:Nicainoprol (RU-42924) is a fast-sodium-channel blocking drug. Nicainoprol is a potent antiarrhythmic agent.Fórmula:C21H27N3O3Pureza:99.54%Forma y color:SolidPeso molecular:369.46Ref: TM-T4539
1mg140,00€5mg344,00€10mg512,00€25mg812,00€50mg1.093,00€100mg1.473,00€1mL*10mM (DMSO)350,00€Oxybuprocaine hydrochloride
CAS:Oxybuprocaine hydrochloride (Oxybuprocaine HCl), a local anesthetic, is used especially in otolaryngology and ophthalmology.Fórmula:C17H29ClN2O3Pureza:99.87%Forma y color:White Crystalline PowderPeso molecular:344.88Amitriptyline hydrochloride
CAS:Amitriptyline hydrochloride (Annoyltin) is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptiveFórmula:C20H24ClNPureza:97% - 99.94%Forma y color:Crystals White To Off-White PowderPeso molecular:313.86
