PDE
Las fosfodiesterasas (PDEs) son enzimas que hidrolizan nucleótidos cíclicos, como el AMPc y el GMPc, en sus formas inactivas, desempeñando un papel clave en la regulación de las vías de señalización intracelular. Los inhibidores de PDE se utilizan en el tratamiento de diversas afecciones, como enfermedades cardiovasculares, disfunción eréctil y trastornos respiratorios, debido a su capacidad para modular los niveles de nucleótidos cíclicos. En CymitQuimica, ofrecemos una gama de inhibidores de PDE para apoyar su investigación en señalización celular, farmacología y desarrollo terapéutico.
Productos de "PDE"
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Ro 20-1724
CAS:Ro 20-1724 (4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone) is a widely used inhibitor of cyclic nucleotide phosphodiesterase with IC50 of 2.0 μM and Ki of 3.1Fórmula:C15H22N2O3Pureza:98% - 99.14%Forma y color:SolidPeso molecular:278.35Deltarasin
CAS:Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.Fórmula:C40H37N5OPureza:99.06%Forma y color:SolidPeso molecular:603.75SEP-0372814
CAS:SEP-0372814 is a potent inhibitor of PDE10.Fórmula:C21H19N7Pureza:99.29%Forma y color:SolidPeso molecular:369.42BC 11-38
CAS:BC 11-38 is a potent, selective PDE biodepressant which is mainly effective against PDE11 (IC50 : 0.28 μM).Fórmula:C15H16N2OS2Pureza:97.71% - 98.72%Forma y color:SolidPeso molecular:304.43Ref: TM-T21865
1mg35,00€5mg70,00€10mg97,00€25mg202,00€50mg329,00€100mg527,00€200mg747,00€1mL*10mM (DMSO)81,00€Zardaverine
CAS:Zardaverine (BY 290) is a PDE3/4 inhibitor with anti-hepatocarcinogenic activity and is used in the study of acute renal failure and chronic airflow obstructionFórmula:C12H10F2N2O3Pureza:99.11%Forma y color:SolidPeso molecular:268.22WAY-313170
CAS:WAY-313170 Inhibits hedgehog signaling and phosphodiesterase.Fórmula:C19H17ClN2O2S2Pureza:99.3%Forma y color:SolidPeso molecular:404.93RS-25344 hydrochloride
CAS:RS 25344 hydrochloride is a phosphodiesterase (PDE) 4 inhibitorFórmula:C19H14ClN5O4Pureza:99.25%Forma y color:SolidPeso molecular:411.8Ref: TM-T23256
2mg34,00€5mg52,00€10mg85,00€25mg170,00€50mg259,00€100mg374,00€200mg545,00€1mL*10mM (DMSO)65,00€ITI-214
CAS:ITI-214 is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members, exhibits potent PDE1 inhibitory activity.Fórmula:C29H29FN7O5PPureza:98.21%Forma y color:SolidPeso molecular:605.56Ref: TM-T11689
1mg74,00€2mg97,00€5mg166,00€10mg303,00€25mg533,00€50mg750,00€100mg1.064,00€1mL*10mM (DMSO)217,00€PF-05180999
CAS:α-2,3-sialyltransferase-IN-1 (Lith-O-Asp analog) is an α-2,3-sialyltransferase inhibitor with anticancer activity.Fórmula:C19H17F3N8Pureza:99.43%Forma y color:SolidPeso molecular:414.39Ziritaxestat
CAS:Ziritaxestat (GLPG1690), an autotaxin inhibitor, currently being evaluated in an exploratory phase 2 study in idiopathic pulmonary fibrosis patients.Fórmula:C30H33FN8O2SPureza:97% - 99.85%Forma y color:SolidPeso molecular:588.7UK 227786
CAS:UK 227786 is an inhibitor of phosphodiesterase 5 (PDE5), used for treatment of prostatic diseases.Fórmula:C22H22Cl2N4O4Pureza:100%Forma y color:SoildPeso molecular:477.34Ref: TM-T11220L
1mg115,00€2mg172,00€5mg255,00€10mg375,00€25mg562,00€50mg792,00€100mg1.064,00€500mg2.147,00€1mL*10mM (DMSO)304,00€Arofylline
CAS:Arofylline (LAS 31025) is a PDE4 inhibitor and can be used for asthma studies.Fórmula:C14H13ClN4O2Pureza:97.98%Forma y color:SolidPeso molecular:304.73Verofylline
CAS:Verofylline (Verofyllinum) is an orally available, long-acting, multiacting, methylxanthine-substituted bronchodilator with inhibitory effects on PDE4 for theFórmula:C12H18N4O2Pureza:97.97% - 99.55%Forma y color:SolidPeso molecular:250.3Siguazodan
CAS:Siguazodan (SKF 94836) is an effective, selective, orally active phosphodiesterase III ((PDE-III)) inhibitor with an IC50 of 117 nM.Fórmula:C14H16N6OPureza:99.63% - 99.77%Forma y color:SolidPeso molecular:284.32Ref: TM-T12913
1mg42,00€5mg88,00€10mg127,00€25mg264,00€50mg424,00€100mg655,00€200mg924,00€1mL*10mM (DMSO)87,00€GSK256066 Trifluoroacetate
CAS:GSK 256066 Trifluoroacetate: selective PDE4 inhibitor, IC50: 3.2 pM for PDE4B, treats COPD.Fórmula:C29H27F3N4O7SForma y color:SolidPeso molecular:632.61THPP-1
CAS:THPP-1 is a potent and orally bioavailable inhibitor of PDE10A(Ki of 1 nM and 1.3 nM for human and rat PDE10A, respectively).Fórmula:C23H21ClN6O3Pureza:99.46%Forma y color:SolidPeso molecular:464.9CI-1044
CAS:CI-1044 is an inhibitor of PDE4 (IC50s: 0.29, 0.08, 0.56, 0.09 μM for PDE4A5, PDE4B2, PDE4C2 and PDE4D3).Fórmula:C23H19N5O2Forma y color:SolidPeso molecular:397.43Anti-ALDH7A1 Antibody-FITC (5P692)
Anti-ALDH7A1 Antibody-FITC (5P692) is a FITC-conjugated Rabbit antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody-FITC (5P692) can be used in FCM.Forma y color:Odour LiquidML-030
CAS:ML-030 is a potent PDE4 inhibitor, selective for subtypes (A1, B1, B2, C1, D2) with IC50 ranging from 6.7 to 452 nM.Fórmula:C20H20N4O4SPureza:97.93%Forma y color:SolidPeso molecular:412.46Nortadalafil
CAS:Nortadalafil, a demethylated form of Tadalafil, is a PDE5 inhibitor used to treat ED and pulmonary arterial hypertension as Adcirca.Fórmula:C21H17N3O4Pureza:99.42%Forma y color:SolidPeso molecular:375.38Ref: TM-T6147
1mg37,00€2mg52,00€5mg79,00€10mg111,00€25mg202,00€50mg354,00€100mg567,00€200mg805,00€500mg1.198,00€1mL*10mM (DMSO)87,00€
