PDE
Las fosfodiesterasas (PDEs) son enzimas que hidrolizan nucleótidos cíclicos, como el AMPc y el GMPc, en sus formas inactivas, desempeñando un papel clave en la regulación de las vías de señalización intracelular. Los inhibidores de PDE se utilizan en el tratamiento de diversas afecciones, como enfermedades cardiovasculares, disfunción eréctil y trastornos respiratorios, debido a su capacidad para modular los niveles de nucleótidos cíclicos. En CymitQuimica, ofrecemos una gama de inhibidores de PDE para apoyar su investigación en señalización celular, farmacología y desarrollo terapéutico.
Productos de "PDE"
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Olprinone
CAS:Olprinone (Loprinone)(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor.Olprinone has been reported to improve microcirculation and attenuateFórmula:C14H10N4OPureza:99.68%Forma y color:SolidPeso molecular:250.26Dovramilast
CAS:Dovramilast (CC-11050) is a PDE4 inhibitor that reduces the production of pro-inflammatory mediators in lupus erythematosus.Fórmula:C24H28N2O6SPureza:98.75% - 99.74%Forma y color:SolidPeso molecular:472.55Anagrelide
CAS:Anagrelide (Xagrid) is a Platelet-reducing Agent.Fórmula:C10H7Cl2N3OPureza:100%Forma y color:SolidPeso molecular:256.09Balipodect
CAS:Balipodect (TAK063) is a highly effective and selective PDE10A inhibitor (IC50: 0.30 nM); Its selectivity is >15000-fold over other PDEs.Fórmula:C23H17FN6O2Pureza:98.32% - 98.97%Forma y color:SolidPeso molecular:428.42Ref: TM-T1745
1mg38,00€2mg49,00€5mg79,00€10mg93,00€25mg156,00€50mg256,00€100mg444,00€1mL*10mM (DMSO)79,00€TPN171
CAS:TPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6, which has the potential for the treatment of pulmonaryFórmula:C24H35N5O3Pureza:100%Forma y color:SolidPeso molecular:441.57PQ-10
CAS:PQ-10 (A-844337) is a PDE-10 inhibitor. PQ-10 induces brain glucose metabolism patterns, which may be a potential translational biomarker.Fórmula:C22H21N5O3Pureza:99.30%Forma y color:SolidPeso molecular:403.43Ref: TM-T24656
2mg34,00€5mg52,00€10mg85,00€25mg170,00€50mg259,00€100mg374,00€200mg545,00€1mL*10mM (DMSO)57,00€Mirodenafil dihydrochloride
CAS:Mirodenafil dihydrochloride is a PDE-5 inhibitor developed for the treatment of erectile dysfunction.Fórmula:C26H39Cl2N5O5SPureza:99.64% - 99.78%Forma y color:SolidPeso molecular:604.59Bay 60-7550
CAS:Bay 60-7550 is a PDE2 inhibitor that exerts positive inotropic effects in the rat heart by increasing PKA-mediated phosphorylation.Fórmula:C27H32N4O4Pureza:98.14%Forma y color:SolidPeso molecular:476.57ENPP1 Inhibitor C
CAS:ML-354 (VU0099704) is an antagonist with and PAR4 for the study of cardiovascular diseases.Fórmula:C15H18N6Forma y color:SolidPeso molecular:282.34Vardenafil dihydrochloride
CAS:Vardenafil dihydrochloride (Levitra) is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.Fórmula:C23H34Cl2N6O4SPureza:98%Forma y color:SolidPeso molecular:561.52Enoximone
CAS:Enoximone is a selective inhibitor of phosphodiesterase III (PDE3), with treatment of congestive heart failure.Fórmula:C12H12N2O2SPureza:95.52%Forma y color:SolidPeso molecular:248.3KD-027
CAS:KD-027 is a novel and long-acting PDE5A(phosphodiesterase 5A) inhibitor with potential antihypertensive activity.Fórmula:C25H35N7O6SPureza:99.55%Forma y color:SolidPeso molecular:561.65MY-5445
CAS:MY-5445 (N-(3-chlorophenyl)-4-phenylphthalazin-1-amine) is a specific inhibitor of phosphodiesterase type 5 (PDE5).Fórmula:C20H14ClN3Pureza:99.77%Forma y color:SolidPeso molecular:331.8BW-A 78U
CAS:BW-A 78U is a PDE4 inhibitor (IC50: 3 μM). It is not inhibition on the lipopolysaccharide (LPS)-induced TNF-α release.Fórmula:C13H12FN5Pureza:99.45%Forma y color:SolidPeso molecular:257.27Ref: TM-T5101
1mg39,00€5mg101,00€10mg153,00€25mg249,00€50mg359,00€100mg507,00€200mg695,00€1mL*10mM (DMSO)44,00€Piclamilast
CAS:Piclamilast (RP 73401) is a PDE4 inhibitor.Fórmula:C18H18Cl2N2O3Pureza:98.28%Forma y color:SolidPeso molecular:381.25Filaminast
CAS:Filaminast (UNII-CDD69JC61J) is an analog of a phosphodiesterase 4 inhibitor (PDE4 inhibitor) and roliplam, which is used as an anti-asthma drug.Fórmula:C15H20N2O4Pureza:98.44% - 99.64%Forma y color:SolidPeso molecular:292.33Ref: TM-T31792
1mg226,00€5mg552,00€10mg735,00€25mg1.111,00€50mg1.491,00€100mg2.005,00€200mg2.707,00€1mL*10mM (DMSO)500,00€Senazodan hydrochloride
CAS:Senazodan hydrochloride (Senazodan HCl) is a Ca2+ sensitizer and phosphodiesterase 3 (PDE3) inhibitor used in the study of cardiovascular diseases.Fórmula:C15H15ClN4OPureza:99.93%Forma y color:SolidPeso molecular:302.76Ensifentrine
CAS:Ensifentrine (Ensifentrinum) is a PDE3/4 inhibitor, although its affinity for PDE3(IC50: 0.4 nM) is 3,440 times higher than that for PDE4(IC50: 1479 nM), thatFórmula:C26H31N5O4Pureza:98.45% - 99.94%Forma y color:SolidPeso molecular:477.56Ref: TM-T25376
1mg35,00€5mg96,00€10mg160,00€25mg329,00€50mg533,00€100mg847,00€200mg1.159,00€1mL*10mM (DMSO)105,00€Lodenafil
CAS:Lodenafil (Hydroxyhomosildenafil) is a potent PDE5 inhibitor, with treatment of erectile dysfunction (ED)Fórmula:C23H32N6O5SPureza:99.92%Forma y color:SolidPeso molecular:504.6Ref: TM-T7346
2mg35,00€5mg50,00€10mg81,00€25mg129,00€50mg187,00€100mg259,00€200mg373,00€1mL*10mM (DMSO)56,00€BAY 2666605
CAS:BAY 2666605 is an orally active inhibitor of PDE3A and PDE3B with IC50s of 87 nM and 50 nM, respectively. BAY 2666605 has anticancer effects.Fórmula:C17H12F4N2O2Pureza:99.98%Forma y color:SolidPeso molecular:352.28Ref: TM-T9805
1mg97,00€5mg235,00€10mg376,00€25mg828,00€50mg1.320,00€100mg2.118,00€1mL*10mM (DMSO)259,00€
