PDE
Las fosfodiesterasas (PDEs) son enzimas que hidrolizan nucleótidos cíclicos, como el AMPc y el GMPc, en sus formas inactivas, desempeñando un papel clave en la regulación de las vías de señalización intracelular. Los inhibidores de PDE se utilizan en el tratamiento de diversas afecciones, como enfermedades cardiovasculares, disfunción eréctil y trastornos respiratorios, debido a su capacidad para modular los niveles de nucleótidos cíclicos. En CymitQuimica, ofrecemos una gama de inhibidores de PDE para apoyar su investigación en señalización celular, farmacología y desarrollo terapéutico.
Productos de "PDE"
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Zatolmilast
CAS:Zatolmilast (BPN14770) is an allosteric inhibitor of selective phosphodiesterase 4D (PDE4D; IC50s: 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3).Fórmula:C21H15ClF3NO2Pureza:98.20%Forma y color:SolidPeso molecular:405.8Ref: TM-T10590
1mg70,00€5mg135,00€10mg245,00€25mg409,00€50mg562,00€100mg780,00€200mg1.026,00€1mL*10mM (DMSO)149,00€Difamilast
CAS:Difamilast is a selective inhibitor of phosphodiesterase-4 (PDE4) with particularly efficient inhibition of subtype B (IC50=11.2 nM).Fórmula:C23H24F2N2O5Pureza:99.04%Forma y color:SolidPeso molecular:446.44Ref: TM-T27172
1mg69,00€5mg149,00€10mg235,00€25mg469,00€50mg753,00€100mg1.216,00€1mL*10mM (DMSO)164,00€Vardenafil hydrochloride
CAS:Vardenafil hydrochloride is a New Phosphodiesterase Type 5(PDE5) Inhibitor, in the Treatment of Erectile Dysfunction in Men With DiabetesFórmula:C23H33ClN6O4SPureza:99.76% - 99.86%Forma y color:White To Off-White Cyrstalline SolidPeso molecular:525.06TP-10
CAS:TP-10 is a selective inhibitor of PDE10A against other PDEs with IC50 of 0.8 nM.Fórmula:C26H19F3N4OPureza:98.48%Forma y color:SolidPeso molecular:460.45Ref: TM-T13189
1mg92,00€2mg120,00€5mg187,00€10mg279,00€25mg487,00€50mg705,00€100mg998,00€500mg1.882,00€1mL*10mM (DMSO)188,00€Tanimilast
CAS:Tanimilast (CHF-6001) is a potent PDE4 inhibitor with IC50 of 0.026 nM, used topically for obstructive lung disease.Fórmula:C30H30Cl2F2N2O8SPureza:98.3%Forma y color:SolidPeso molecular:687.54PDE5-IN-9
CAS:WAY-639921 treats cardiovascular and respiratory conditions by inhibiting PDE1c.Fórmula:C18H14N4SPureza:100%Forma y color:SolidPeso molecular:318.4K-Ras-PDEδ-IN-1
CAS:K-Ras-PDEδ-IN-1 is a potent inhibitor of competitive K-Ras-PDEδ.It binds to the farnesyl binding pocket of PDEδ(Kd of 8 nM).Fórmula:C25H26FN5O2Pureza:99.48%Forma y color:SolidPeso molecular:447.5Isomazole
CAS:Isomazole is a novel orally available phosphodiesterase (PDE) inhibitor with calcium-sensitizing properties that inhibits PDE3 and PDE4.Fórmula:C14H13N3O2SPureza:99.12%Forma y color:SolidPeso molecular:287.34Cilostazol
CAS:Cilostazol (OPC 21) is a Phosphodiesterase 3 Inhibitor. The mechanism of action of cilostazol is as a Phosphodiesterase 3 Inhibitor.Fórmula:C20H27N5O2Pureza:99.58% - 99.90%Forma y color:Off-White SolidPeso molecular:369.46Nanterinone
CAS:Nanterinone: oral phosphodiesterase inhibitor, improves acute heart failure hemodynamics.Fórmula:C15H15N3OPureza:99.11%Forma y color:SolidPeso molecular:253.3EMD57439
CAS:EMD57439 is a selective PDE-III inhibitor, showing no significant increase in c-AMP concentration and producing little change in Ca(50).Fórmula:C22H23N3O4SPureza:98% - 99.38%Forma y color:SolidPeso molecular:425.5MK-0873
CAS:MK-0873 is a novel and potent selective phosphodiesterase 4 (PDE4) inhibitor.Fórmula:C25H18N4O3Pureza:99.29%Forma y color:SolidPeso molecular:422.44Anagrelide hydrochloride
CAS:Anagrelide hydrochloride (BL4162A) serves as a treatment for essential thrombocytosis.Fórmula:C10H7Cl2N3O·HClPureza:99.58%Forma y color:Off-White PowderPeso molecular:292.55Oglemilast
CAS:Oglemilast (GRC 3886) suppresses pulmonary cell infiltration, including eosinophilia and neutrophilia in vitro and in vivo.Fórmula:C20H13Cl2F2N3O5SPureza:98.11%Forma y color:SolidPeso molecular:516.3Anti-ALDH7A1 Antibody (1G435)
Anti-ALDH7A1 Antibody (1G435) is a Mouse antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody (1G435) can be used in ELISA.Forma y color:Odour LiquidTAK-915
CAS:TAK-915: potent, brain-ready PDE2A inhibitor, 0.61 nM IC50, 4100x selectivity over PDE1A.Fórmula:C19H18F4N4O5Pureza:98%Forma y color:SolidPeso molecular:458.36Crisaborole
CAS:Crisaborole (AN-2728) is a Phosphodiesterase 4 Inhibitor.Fórmula:C14H10BNO3Pureza:99.70%Forma y color:SolidPeso molecular:251.05Cudetaxestat
CAS:Cudetaxestat (BLD-0409) is a potent inhibitor of orally active autotaxin.Fórmula:C21H15Cl2F2N3O2SPureza:98.84%Forma y color:SolidPeso molecular:482.33Ref: TM-T63190
1mg77,00€5mg170,00€10mg248,00€25mg444,00€50mg662,00€100mg929,00€200mg1.225,00€1mL*10mM (DMSO)170,00€Ibudilast
CAS:Ibudilast (MN-166)(KC-404;AV-411;MN-166) is a relatively nonselective phosphodiesterase inhibitor. It is approved for use as an anti-inflammatory in Japan.Fórmula:C14H18N2OPureza:99.34% - 99.94%Forma y color:White SolidPeso molecular:230.31Enpp-1-IN-14
CAS:Enpp-1-IN-14: potent ENPP1 inhibitor, IC50 = 32.38 nM, exhibits anti-tumor properties.Fórmula:C15H22ClN5O4SPureza:100%Forma y color:SoildPeso molecular:403.88
