PDE
Las fosfodiesterasas (PDEs) son enzimas que hidrolizan nucleótidos cíclicos, como el AMPc y el GMPc, en sus formas inactivas, desempeñando un papel clave en la regulación de las vías de señalización intracelular. Los inhibidores de PDE se utilizan en el tratamiento de diversas afecciones, como enfermedades cardiovasculares, disfunción eréctil y trastornos respiratorios, debido a su capacidad para modular los niveles de nucleótidos cíclicos. En CymitQuimica, ofrecemos una gama de inhibidores de PDE para apoyar su investigación en señalización celular, farmacología y desarrollo terapéutico.
Productos de "PDE"
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Carbazeran
CAS:Carbazeran (UK-31,557) is an inhibitor of PDE2 and PDE3 and can be used for studies about metabolic diseases.Fórmula:C18H24N4O4Pureza:97.28%Forma y color:SolidPeso molecular:360.41Autotaxin modulator 1
CAS:Autotaxin modulator 1 is a new modulator of Autotaxin.Fórmula:C28H31F6NO3Forma y color:SolidPeso molecular:543.54Osoresnontrine
CAS:Osoresnontrine is a potent and selective inhibitor of PDE9A (IC50 of 52 nM),and can be used in the research of memory.Fórmula:C16H17N5O2Pureza:99.93%Forma y color:SolidPeso molecular:311.34Ref: TM-T8515
1mg38,00€2mg50,00€5mg81,00€10mg119,00€25mg188,00€50mg350,00€100mg522,00€200mg748,00€1mL*10mM (DMSO)89,00€PDE IV-IN-1
CAS:PDE IV-IN-1 is a potent phosphodiesterase 4 (PDE4) inhibitor with anti-inflammatory activity for the treatment of asthma, chronic obstructive pulmonary diseaseFórmula:C20H23ClN4O2Pureza:98.57%Forma y color:SolidPeso molecular:386.88Ref: TM-T10201
1mg341,00€5mg723,00€10mg969,00€25mg1.454,00€50mg1.948,00€100mg2.632,00€1mL*10mM (DMSO)815,00€ALDH7A1 Protein, Human, Recombinant (His)
ALDH7A1 (Aldehyde dehydrogenase 7 family, member A1) is a member of subfamily 7 in the aldehyde dehydrogenase family.Forma y color:Lyophilized PowderPeso molecular:56 kDa (predicted); 56 kDa (reducing conditions)Anti-ALDH7A1 Antibody (6G475)
Anti-ALDH7A1 Antibody (6G475) is a Mouse antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody (6G475) can be used in IHC-P.Forma y color:Odour LiquidRS-25344
CAS:RS-25344: a strong PDE4 blocker, curbs eosinophil movement, boosts sperm motility in vitro.Fórmula:C19H13N5O4Pureza:98.98%Forma y color:SolidPeso molecular:375.34Ref: TM-T9239
1mg88,00€5mg172,00€10mg259,00€25mg425,00€50mg598,00€100mg810,00€200mg1.074,00€1mL*10mM (DMSO)187,00€ATX inhibitor 5
CAS:ATX inhibitor 5: potent, oral autotaxin blocker, IC50 15.3 nM, curbs CCl4 liver fibrosis.Fórmula:C22H18ClF3N6OPureza:99.23%Forma y color:SolidPeso molecular:474.87Ref: TM-T10409
1mg64,00€5mg140,00€10mg219,00€25mg373,00€50mg510,00€100mg695,00€200mg937,00€1mL*10mM (DMSO)145,00€PDE7-IN-2
CAS:PDE7-IN-2 is an inhibitor of phosphodiesterase 7 (IC50 = 2.1 µM) and can be used in Parkinson's disease studies.Fórmula:C14H11ClN2O3SPureza:98%Forma y color:SolidPeso molecular:322.77IBMX
CAS:IBMX (Methylisobutylxanthine) is a broad-spectrum phosphodiesterase (PDE) inhibitor with inhibitory activity against PDE3, PDE4, and PDE5 (IC50=6.5/26.3/31.7 μMFórmula:C10H14N4O2Pureza:100% - 99.99%Forma y color:Off-WhitePeso molecular:222.24GSK256066
CAS:GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380, 000-fold selectivity versus PDE1/2/3/5/6 and >2500-foldFórmula:C27H26N4O5SPureza:99.52% - 99.66%Forma y color:SolidPeso molecular:518.58PDE9-IN-1
CAS:PDE9-IN-1 is a selective and orally bioavailable Inhibitor of PDE9A(IC50 of 8.7 nM).Fórmula:C17H23FN6O2Pureza:100%Forma y color:SolidPeso molecular:362.4Autotaxin-IN-4
CAS:Autotaxin-IN-4 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.Fórmula:C22H21N9O2Pureza:98%Forma y color:SolidPeso molecular:443.46PDE9-IN-(S)-C33
CAS:PDE9-IN-(S)-C33: potent PDE9 inhibitor with 11 nM IC50, for CNS diseases and diabetes study.Fórmula:C18H20ClN5OPureza:98.75%Forma y color:SolidPeso molecular:357.84Ref: TM-T28352
1mg39,00€5mg73,00€10mg94,00€25mg153,00€50mg219,00€100mg325,00€200mg465,00€1mL*10mM (DMSO)84,00€Adibendan
CAS:Adibendan (Adibendanum) is a selective inhibitor of PDE3 with an IC50 of 2.0 μM.Fórmula:C16H14N4OPureza:100% - 99.61%Forma y color:SolidPeso molecular:278.31Ref: TM-T23638
1mg115,00€2mg172,00€5mg255,00€10mg375,00€25mg562,00€50mg792,00€100mg1.064,00€500mgA consultar1mL*10mM (DMSO)240,00€PF-04822163
CAS:PF-04822163 is a potent inhibitor of PDE1 with IC50 value of 0.0024 μM.Fórmula:C19H17ClN2O2Pureza:100%Forma y color:SolidPeso molecular:340.8Lotamilast
CAS:Lotamilast (RVT-501) is a phosphodiesterase 4 (PDE-4) inhibitor (IC50: 2.8 nM) potentially for the treatment of atopic dermatitis.Fórmula:C26H24N4O5Pureza:97.03% - 99.29%Forma y color:SolidPeso molecular:472.49Ref: TM-T3987
1mg34,00€2mg47,00€5mg70,00€10mg96,00€25mg170,00€50mg298,00€100mg430,00€200mg607,00€1mL*10mM (DMSO)71,00€HA130
CAS:HA130 is a selective ATX (autotaxin) inhibitor.Fórmula:C24H19BFNO5SPureza:100% - ≥95%Forma y color:SolidPeso molecular:463.29Ref: TM-T2646
2mg39,00€5mg57,00€10mg93,00€25mg145,00€50mg235,00€100mg351,00€200mg528,00€1mL*10mM (DMSO)58,00€ICI 63197
CAS:ICI 63197 (2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one) is a PDE4 inhibitor.Fórmula:C9H13N5OPureza:99.02%Forma y color:White SolidPeso molecular:207.23PDE4B-IN-2
CAS:PDE4B-IN-2 (A 33), an oral PDE4B inhibitor, IC50: 15 nM; less potent on PDE4D (IC50: 1.7 µM), has anti-inflammatory properties.Fórmula:C19H18ClN3O2SPureza:99.37%Forma y color:SolidPeso molecular:387.88Ref: TM-T36832
1mg37,00€5mg79,00€10mg111,00€25mg216,00€50mg354,00€100mg567,00€500mg1.198,00€1mL*10mM (DMSO)87,00€
