PPAR
Los receptores activados por proliferadores de peroxisomas (PPARs) son un grupo de proteínas receptoras nucleares que funcionan como factores de transcripción regulando la expresión de genes involucrados en el metabolismo, particularmente en el almacenamiento de ácidos grasos y el metabolismo de la glucosa. Los inhibidores de PPAR son herramientas importantes para estudiar trastornos metabólicos como la diabetes, la obesidad y las enfermedades cardiovasculares. Estos inhibidores pueden modular el metabolismo de los lípidos, la sensibilidad a la insulina y la inflamación, lo que los convierte en valiosos en la investigación terapéutica. En CymitQuimica, ofrecemos una gama de inhibidores de PPAR para apoyar su investigación en enfermedades metabólicas, endocrinología y desarrollo de fármacos.
Productos de "PPAR"
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LG100754
CAS:LG100754 (UVI 2112) is an insulin sensitizer and RXR modulator, antagonizing RXR homodimers while agonizing RXR:PPARα/γ heterodimers.Fórmula:C26H36O3Forma y color:SolidPeso molecular:396.56AMG131
CAS:AMG131 (CHS 131) , is a novel, non-thiazolidinedione (TZD), selective peroxisome proliferator-activated receptor (PPAR)gamma modulator, which can be used forFórmula:C21H12Cl4N2O3SPureza:99.37%Forma y color:SolidPeso molecular:514.21SR1664
CAS:SR1664 is a potent and selective PPARγ inhibitor with potential antidiabetic activity.Fórmula:C33H29N3O5Pureza:98.02%Forma y color:SolidPeso molecular:547.6Ref: TM-T23389
1mg52,00€2mg74,00€5mg111,00€10mg144,00€25mg305,00€50mg543,00€100mg780,00€500mg1.605,00€1mL*10mM (DMSO)123,00€NSC-87877 disodium
CAS:NSC-87877 disodium (NSC87877) is a cell-permeable inhibitor of both SHP-1 and SHP-2. NSC-87877 also inhibits EGF-induced Erk1/2 activation in HEK293 cells.Fórmula:C19H13N3O7S2·2NaPureza:97.89%Forma y color:SolidPeso molecular:503.42CC618
CAS:CC618 is a selective PPARβ/δ antagonist with an IC50 of 10.0 μM.Fórmula:C20H15F6N3O3S2Pureza:99.37%Forma y color:SolidPeso molecular:523.47Ref: TM-T9767
1mg115,00€5mg249,00€10mg369,00€25mg562,00€50mg787,00€100mg1.054,00€200mg1.406,00€1mL*10mM (DMSO)314,00€PPARγ agonist 8
CAS:PPARγ agonist 8, a compound that acts on the peroxisome proliferator-activated receptor gamma (PPARγ), has been shown to stimulate peroxisome proliferatorFórmula:C19H12F4O2SPureza:98%Forma y color:SolidPeso molecular:380.36Clofibric acid
CAS:Clofibric acid (Chlorofibrinic acid) is an antilipemic agent that is the biologically active metabolite of CLOFIBRATE.Fórmula:C10H11ClO3Pureza:99.47% - 99.8%Forma y color:Pale Yellow SolidPeso molecular:214.65OPHIOPOGONIN D
CAS:Ophiopogonin D is a natural product,and is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation.Fórmula:C44H70O16Pureza:99.46% - ≥95%Forma y color:SolidPeso molecular:855.02CDDO-Im
CAS:CDDO-Im (TP-235) is an activator of Nrf2 and PPAR (Kis: 232/344 nM for PPARα/PPARγ).Fórmula:C34H43N3O3Pureza:100% - 98.3%Forma y color:SolidPeso molecular:541.72Ref: TM-TQ0120
1mg37,00€5mg79,00€10mg111,00€25mg210,00€50mg338,00€100mg512,00€500mg1.093,00€1mL*10mM (DMSO)94,00€Rosiglitazone
CAS:Rosiglitazone (BRL49653) is a PPARγ agonist, TRPC5 activator, and TRPM3 inhibitor with oral activity.Fórmula:C18H19N3O3SPureza:98.61% - 99.87%Forma y color:White To Off-White Crystalline PowderPeso molecular:357.43Daltroban
CAS:Daltroban (SKF 96148) is a specific thromboxane A2 (TXA2) receptor antagonist.Fórmula:C16H16ClNO4SPureza:99.49%Forma y color:SolidPeso molecular:353.82Ref: TM-T15049
1mg58,00€5mg129,00€10mg187,00€25mg311,00€50mg444,00€100mg605,00€200mg815,00€1mL*10mM (DMSO)117,00€AVE-8134
CAS:AVE-8134 is an agonist of PPARα. For human and rodent PPARα receptor, the EC50 values are 100 and 3000 nM, respectively.Fórmula:C22H23NO5Pureza:98%Forma y color:SolidPeso molecular:381.42PPARδ agonist 11
CAS:Compound 11, a selective PPARδ agonist, demonstrates an EC50 of 20 nM, indicating its high affinity for PPARδ receptors. This compound efficiently reduces levels of nitric oxide (NO), as well as the pro-inflammatory cytokines TNFα and IL-6 in LPS-stimulated RAW264.7 cells via the NF-κB pathway, showcasing its anti-inflammatory properties. Additionally, Compound 11 exhibits remarkable stability in human liver microsomes and plasma. It significantly ameliorates foot edema induced by Carrageenan, displaying favorable pharmacokinetic properties with a bioavailability of approximately 100%.Fórmula:C19H15F3N2O3S2Forma y color:SolidPeso molecular:440.46Muraglitazar
CAS:Muraglitazar (BMS-298585) is a PPAR α/γ dual agonist for the treatment of type 2 diabetes and associated dyslipidemia.Fórmula:C29H28N2O7Pureza:99.31%Forma y color:SolidPeso molecular:516.54SP4f
SP4f, an activator of PPAR-γ, exhibits an EC50 value of 826 nM in HK-2 cells.Pureza:98%Forma y color:Odour SolidOroxin A
CAS:Oroxin A, a partial PPARγ agonist, activates PPARγ, inhibits α-glucosidase, and has antioxidant properties.Fórmula:C21H20O10Pureza:98%Forma y color:SolidPeso molecular:432.38Eupatilin
CAS:Eupatilin (NSC-122413), a flavone derived from Artemisia princepsPampanini, is a PPARα agonist, with pharmacological activity.Fórmula:C18H16O7Pureza:98.42% - 99%Forma y color:SolidPeso molecular:344.32Indeglitazar
CAS:Indeglitazar (PPM 204) is orally available pan-agonist of PPAR (PPAR subtypes alpha (α), delta (δ), and gamma (γ)).Fórmula:C19H19NO6SPureza:99.73%Forma y color:SolidPeso molecular:389.42Magnolol
CAS:Magnolol (5,5'-Diallyl-2,2'-biphenyldiol) is a dual agonist of RXRα( EC50=10.4 μM) and PPARγ(EC50=17.7 μM). It blocks TNF-α-induced NF-KB activation.Fórmula:C18H18O2Pureza:99.49%Forma y color:A Bioactive Compound Found In The Bark Of The Houpu MagnoliaPeso molecular:266.33L-165041
CAS:L-165041 is a potent and selective agonist of the nuclear receptor PPARβ and PPARδ(Ki = 9 nM, EC50 = ~500 nM ,respectively)Fórmula:C22H26O7Pureza:97.97%Forma y color:SolidPeso molecular:402.44
