Fosfolipasa
Las fosfolipasas son un grupo de enzimas que hidrolizan fosfolípidos en ácidos grasos y otras sustancias lipofílicas, desempeñando un papel crítico en la biología de las membranas y la generación de moléculas de señalización. Los inhibidores de fosfolipasas se utilizan para estudiar su papel en enfermedades inflamatorias, trastornos cardiovasculares y neurodegeneración. Estos inhibidores también son valiosos para explorar las vías de señalización de lípidos y sus implicaciones en los mecanismos de enfermedades. En CymitQuimica, ofrecemos una variedad de inhibidores de fosfolipasas para apoyar su investigación en inflamación, metabolismo de lípidos y señalización celular.
Productos de "Fosfolipasa"
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Cambinol
CAS:Cambinol is a SIRT1/2 inhibitor (IC50: 56/59 μM), non-competitive with NAD, weak on SIRT5, and prompts apoptosis in lymphoma cells.Fórmula:C21H16N2O2SPureza:98.47% - 99.83%Forma y color:SolidPeso molecular:360.43Ref: TM-T4019
1mg40,00€2mg52,00€5mg85,00€10mg124,00€25mg219,00€50mg350,00€100mg522,00€500mg1.130,00€1mL*10mM (DMSO)66,00€A4333
A4333, a biotinylated derivative of A3373, selectively inhibits Phospholipase D1 (PLD1) while sparing PLD2.Pureza:98%Forma y color:Odour SolidSB-435495
CAS:SB-435495 is a compound characterized by its potent, selective, reversible, and non-covalent inhibition of Lp-PLA2, demonstrating an IC50 value of 0.06 nM.Fórmula:C38H40F4N6O2SPureza:≥98%Forma y color:SolidPeso molecular:720.82Difluprednate
CAS:Difluprednate (Myser)(Durezol) is a corticosteroid, approved for the treatment of post-operative ocular inflammation and pain.Fórmula:C27H34F2O7Pureza:99.23% - 99.86%Forma y color:SolidPeso molecular:508.55Ref: TM-T6472
10mg39,00€25mg55,00€50mg80,00€100mg101,00€200mg177,00€500mg283,00€1mL*10mM (DMSO)48,00€Lp-PLA2-IN-14
CAS:Lp-PLA2-IN-14 (Compound 19), an inhibitor of rhLp-PLA2, exhibits a potent inhibitory effect with a pIC50 value of 8.4.Fórmula:C16H14F3N3O3Pureza:98%Forma y color:SolidPeso molecular:353.3ML349
CAS:ML349 is an inhibitor of LYPLA2 (IC50: 144 nM). ML349 is an effective and specific acyl protein thioesterase 2 (APT-2) inhibitor (Ki: 120 nM).Fórmula:C23H22N2O4S2Pureza:99.59% - 99.82%Forma y color:SolidPeso molecular:454.56FAAH/cPLA2α-IN-1
CAS:FAAH/cPLA2α-IN-1 is a compound that simultaneously inhibits both FAAH and cPLA2α, demonstrating potent activity with half-maximal inhibitory concentrations (Fórmula:C19H26N4O5Pureza:98%Forma y color:SolidPeso molecular:390.43ASM-IN-1
CAS:ASM-IN-1: Oral acid sphingomyelinase inhibitor, IC50 = 1.5 µM; reduces lipid plaques, plasma ceramide, Ox-LDL.Fórmula:C16H12BrN3O4Pureza:98%Forma y color:SolidPeso molecular:390.19A3373
CAS:A3373 is a novel inhibitor targeting both Phospholipase D1 (PLD1) and Phospholipase D2 (PLD2), demonstrating half maximal inhibitory concentrations (IC50) ofFórmula:C17H9F7N2OPureza:98%Forma y color:SoildPeso molecular:390.26CAY10650
CAS:CAY10650 is an effective inhibitor of cytosolic phospholipase A2α (cPLA2α, IC50: 12 nM).Fórmula:C28H25NO6Pureza:95.56%Forma y color:SolidPeso molecular:471.5Ref: TM-TQ0105
1mg51,00€5mg137,00€10mg210,00€25mg424,00€50mg628,00€100mg938,00€1mL*10mM (DMSO)140,00€VU0359595
CAS:VU0359595 (ML-270) is a selective PLD1 inhibitor with 3.7 nM IC50; >1700x more selective over PLD2, for cancer/diabetes/neurodegenerative research.Fórmula:C25H29BrN4O2Pureza:99.15%Forma y color:SolidPeso molecular:497.43ST271
CAS:ST271 is an effective protein tyrosine kinase (PTK) inhibitor.Fórmula:C16H20N2O2Pureza:98.94%Forma y color:SolidPeso molecular:272.34VU0364739
CAS:VU0364739, a selective phospholipase D2 (PLD2) inhibitor with an IC50 of 22 nM, effectively reduces cancer cell proliferation [1].Fórmula:C26H27FN4O2Pureza:98%Forma y color:SolidPeso molecular:446.52BMS493
CAS:BMS493 is an inverse agonist of RAR that inhibits retinoic acid-induced differentiation and inhibits the increase in phospholipase A2 activity.Fórmula:C29H24O2Pureza:100%Forma y color:SolidPeso molecular:404.5Varespladib methyl
CAS:Varespladib methyl (LY333013), a bioavailable prodrug of Varespladib, is a selective group II secretory phospholipase A2 inhibitor.Fórmula:C22H22N2O5Pureza:100% - 99.69%Forma y color:SolidPeso molecular:394.42Ref: TM-T17218
1mg117,00€5mg283,00€10mg454,00€25mg750,00€50mg1.026,00€100mg1.406,00€500mg2.822,00€1mL*10mM (DMSO)423,00€PACOCF3
CAS:PACOCF3, a phospholipase A2 inhibitor, hinders Ca2+ signaling with an IC50 of 3.8 μM in renal cells.Fórmula:C17H31F3OPureza:99.57%Forma y color:SolidPeso molecular:308.42Lp-PLA2-IN-2
CAS:Lp-PLA2-IN-2 is a selective and potent lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor, with an IC50 0f 120 nM for recombinant human Lp-PLA2.Fórmula:C19H23FN2O4SPureza:98%Forma y color:SolidPeso molecular:394.46MAFP
CAS:MAFP (Methyl Arachidonyl Fluorophosphonate) is an effective irreversible inhibitor of anandamide amidase.Fórmula:C21H36FO2PForma y color:SolidPeso molecular:370.48m-3M3FBS
CAS:m-3M3FBS is a phospholipase C (PLC) activator.Fórmula:C16H16F3NO2SPureza:99.66%Forma y color:SolidPeso molecular:343.36Rapanone
CAS:Rapanone (2,5-Dihydroxy-3-tridecyl-[1,4]benzoquinone) is a natural benzoquinone that is a potent and selective inhibitor of human synovial PLA2.Fórmula:C19H30O4Pureza:99.56% - 99.56%Forma y color:SolidPeso molecular:322.44
