
GluR
Inhibidores del Receptor de Glutamato son compuestos que bloquean la actividad de los receptores de glutamato, los principales receptores de neurotransmisores excitatorios en el cerebro. Estos receptores desempeñan un papel crucial en la transmisión sináptica, la plasticidad, el aprendizaje y la memoria. La desregulación de la señalización de glutamato está asociada con varios trastornos neurológicos, como la epilepsia, el accidente cerebrovascular y las enfermedades neurodegenerativas. Los inhibidores de los receptores de glutamato son esenciales para investigar los mecanismos de la excitotoxicidad y desarrollar estrategias neuroprotectoras. En CymitQuimica, ofrecemos una gama de inhibidores de receptores de glutamato para apoyar su investigación en la función sináptica, la neuroprotección y los trastornos cognitivos.
Productos de "GluR"
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ADX88178
CAS:ADX88178 is a potent positive allosteric modulator for metabotropic glutamate receptor 4 (mGluR4) with EC50 of 4 nM for human mGluR4.Fórmula:C12H12N6SPureza:99.55%Forma y color:SolidPeso molecular:272.33Ref: TM-T4500
2mg38,00€5mg58,00€10mg96,00€25mg156,00€50mg243,00€100mg354,00€200mg505,00€1mL*10mM (DMSO)60,00€LY392098
CAS:LY392098 (AMPA receptor modulator-3) is an allosteric modulator of AMPA receptor with EC50 of 4.4 μM and can be used in studies about mammalian nervous system.Fórmula:C18H22FNO2SPureza:99.85%Forma y color:SolidPeso molecular:335.44Ref: TM-T27951
1mg42,00€5mg87,00€10mg140,00€25mg226,00€50mg324,00€100mg437,00€200mg605,00€1mL*10mM (DMSO)92,00€NS 1209
CAS:NS 1209 (SPD 502) is a AMPA receptor antagonist.Fórmula:C24H27N4NaO7SPureza:98%Forma y color:SolidPeso molecular:538.55PHCCC
CAS:PHCCC is a Group I mGluR antagonist and enhances mGluR4 function; also blocks mGluR2/8.Fórmula:C17H14N2O3Pureza:99.31%Forma y color:SolidPeso molecular:294.3(S)-3,4-DCPG HCl
(S)-3,4-DCPG HCl is a selective mGluR8a agonist, impacting AV12-664 cells with an EC50 of 31 nM.Fórmula:C10H10ClNO6Pureza:99.06% - 99.90%Forma y color:SoildPeso molecular:275.64Ref: TM-T23288L
1mg183,00€5mg462,00€10mg660,00€25mg1.035,00€50mg1.415,00€100mg1.872,00€500mg3.763,00€1mL*10mM (DMSO)415,00€Dasolampanel
CAS:Dasolampanel (NGX-426) is an ionotropic glutamate receptor AMPA and Kainate receptor antagonist for the study of chronic pain disorders.Fórmula:C17H20ClN5O3Pureza:99%Forma y color:SolidPeso molecular:377.83VU0360172
CAS:VU0360172 is a positive allosteric modulator of mGlu5 receptors (EC50 = 16 nM; Ki = 195 nM).Fórmula:C18H15FN2OPureza:99.65%Forma y color:SolidPeso molecular:294.32Ref: TM-T29126
1mg57,00€5mg120,00€10mg187,00€25mg376,00€50mg588,00€100mg833,00€1mL*10mM (DMSO)115,00€XAP044
CAS:XAP044 blocks mGlu7, inhibiting long-term potentiation in mouse brain with a half-maximal effect at 88nm.Fórmula:C15H9IO4Pureza:97.41%Forma y color:SolidPeso molecular:380.13Ref: TM-T21995
1mg62,00€2mg87,00€5mg113,00€10mg207,00€25mg369,00€50mg557,00€100mg797,00€1mL*10mM (DMSO)155,00€DHPG
CAS:DHPG is a potent Group I mGluR agonist; doesn't affect Group II/III; linked to phospholipase D.Fórmula:C8H9NO4Pureza:99.55%Forma y color:SolidPeso molecular:183.16VU0361737
CAS:VU0361737 (ML-128) is a mGlu4 PAM; EC50 is 240 nM (human) and 110 nM (rat), weak at mGlu5/8, inactive at mGlu1/2/3/6/7, CNS-penetrant.Fórmula:C13H11ClN2O2Pureza:99.09% - 99.86%Forma y color:SolidPeso molecular:262.69Philanthotoxin 74 dihydrochloride
CAS:Philanthotoxin 74 dihydrochloride is an antagonist of AMPAR with IC50s of 263 and 296 nM for GluR3 and GluR1.Fórmula:C24H44Cl2N4O3Pureza:98.6%Forma y color:SolidPeso molecular:507.54CNQX
CAS:CNQX (FG9065) is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.3 and 1.5 μM for AMPA and kainate receptors, respectively)Fórmula:C9H4N4O4Pureza:99.70%Forma y color:Pale Yellow SolidPeso molecular:232.15Ro 67-7476
CAS:Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors.Fórmula:C17H18FNO2SPureza:99.48%Forma y color:SolidPeso molecular:319.39Ref: TM-T3478
1mg35,00€2mg50,00€5mg93,00€10mg131,00€25mg258,00€50mg465,00€100mg680,00€1mL*10mM (DMSO)82,00€JNJ-46281222
CAS:JNJ-46281222: mGlu2-selective, potent PAM, Kd = 1.7 nM, pEC50 = 7.71.Fórmula:C23H25F3N4Forma y color:SolidPeso molecular:414.47Ref: TM-T8862
1mg37,00€5mg80,00€10mg116,00€25mg259,00€50mg383,00€100mg545,00€200mg740,00€1mL*10mM (DMSO)93,00€IDRA-21
CAS:IDRA-21 is a positive AMPA receptor modulator.Fórmula:C8H9ClN2O2SPureza:99.73%Forma y color:SolidPeso molecular:232.69DMeOB
CAS:DMeOB (3,3'-Dimethoxybenzaldazine) is a negative regulator with mGluR5 agonist activity and is used in the study of neurological disorders.Fórmula:C16H16N2O2Pureza:98.34%Forma y color:SolidPeso molecular:268.31Ref: TM-T22736
1mg35,00€5mg70,00€10mg104,00€25mg202,00€50mg311,00€100mg472,00€500mg1.017,00€1mL*10mM (DMSO)85,00€JNJ-55511118
CAS:JNJ-55511118 is a TARP γ8 allosteric modulator with anticonvulsant activity, which can be used in research on chronic operant alcohol self-administration.Fórmula:C14H8ClF3N2O2Forma y color:SolidPeso molecular:328.67Pomaglumetad methionil hydrochloride
CAS:LY2140023 hydrochloride: oral methionine prodrug of LY404039, a selective mGlu2/3 agonist, studied for schizophrenia.Fórmula:C12H19ClN2O7S2Pureza:99.01%Forma y color:SolidPeso molecular:402.87Basimglurant
CAS:Basimglurant (CTEP Derivative) is a potent, selective and orally available modulator of mGlu5 negative allosteric(Kd of 1.1 nM).Fórmula:C18H13ClFN3Pureza:98.35%Forma y color:SolidPeso molecular:325.77Ref: TM-T12717
1mg78,00€5mg169,00€10mg246,00€25mg406,00€50mg562,00€100mg702,00€200mg949,00€1mL*10mM (DMSO)178,00€