Receptor del factor de crecimiento de fibroblastos (FGFR)
Los inhibidores de FGFR (receptores del factor de crecimiento de fibroblastos) son terapias dirigidas que bloquean la actividad de los FGFR, los cuales están involucrados en la proliferación celular, diferenciación y angiogénesis. La señalización de FGFR contribuye a la formación de nuevos vasos sanguíneos en los tumores, promoviendo su crecimiento y supervivencia. Inhibir FGFR puede, por lo tanto, reducir la angiogénesis y la progresión tumoral. En CymitQuimica, ofrecemos una gama de inhibidores de FGFR de alta calidad para apoyar su investigación en cáncer, biología del desarrollo y angiogénesis.
Productos de "Receptor del factor de crecimiento de fibroblastos (FGFR)"
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R1530
CAS:R1530 is a multikinase inhibitor with antineoplastic and antiangiogenesis activities.Fórmula:C18H14ClFN4OPureza:97.96%Forma y color:SolidPeso molecular:356.78TYRA-300
CAS:TYRA-300 is an oral and selective FGFR3 inhibito, in the Ba/F3 cell line for the treatment of metastatic uroepithelial carcinomas (mUCs) and chondrodysplasia.Fórmula:C25H24Cl2N6O3SPureza:99.66%Forma y color:SolidPeso molecular:559.47Ref: TM-T88841
1mg404,00€5mg735,00€10mg999,00€25mg1.588,00€50mg2.147,00€100mg2.902,00€1mL*10mM (DMSO)904,00€KHS101 hydrochloride
CAS:KHS101 is a TACC3 inhibitor and can selectively induce a neuronal differentiation phenotype.Fórmula:C18H22ClN5SPureza:99.6%Forma y color:SolidPeso molecular:375.92Ref: TM-T5170
2mg37,00€5mg55,00€10mg85,00€25mg156,00€50mg251,00€100mg369,00€200mg525,00€1mL*10mM (DMSO)62,00€PD-161570
CAS:PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM.Fórmula:C26H35Cl2N7OPureza:99.23%Forma y color:SolidPeso molecular:532.51Ref: TM-T23127
1mg35,00€5mg92,00€10mg149,00€25mg305,00€50mg492,00€100mg700,00€200mg938,00€1mL*10mM (DMSO)125,00€Pazopanib
CAS:Pazopanib (GW786034) is an inhibitor of protein tyrosine kinases that inhibits VEGFR1/2/3. Pazopanib has antitumor activity. Cost-effective and quality-assured.Fórmula:C21H23N7O2SPureza:98.78% - 99.72%Forma y color:White PowderPeso molecular:437.52Ref: TM-T0097L
10mg49,00€25mg73,00€50mg96,00€100mg145,00€200mg236,00€500mg331,00€1mL*10mM (DMSO)59,00€BW710
BW710 is an orally active inhibitor specifically targeting fibroblast growth factor receptor 2 (FGFR2). It effectively inhibits the proliferation of BaF3-FGFR2 cells with an IC50 value of 2.8 nM. BW710 completely suppresses FGFR2 enzymatic activity and demonstrates selectivity among 75 tyrosine kinases, including FGFR1, FGFR3, and FGFR4, at a 1 μM concentration. Additionally, BW710 impedes FGFR2 signaling and selectively inhibits the proliferation of cancer cells driven by FGFR2. It exhibits promising pharmacokinetic properties, with an oral bioavailability of 29% in mice.Fórmula:C28H29FN6O2SForma y color:SolidPeso molecular:532.63XL 999
CAS:Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor(KDR, Flt-1, FGFR1 and PDGFRα with IC50s of 4nM, 20nM, 4nM, 2 nM ,respectively)Fórmula:C26H28FN5OPureza:98.24% - 99.55%Forma y color:SolidPeso molecular:445.53FGFR4-IN-16
CAS:FGFR4-IN-16 (CY-15-2) is a covalent inhibitor targeting FGFR-4, utilized in cancer research [1].Fórmula:C35H30Cl2N6O5Pureza:98%Forma y color:SolidPeso molecular:685.56Rogaratinib
CAS:Rogaratinib (BAY1163877) is an aberrant inhibitor of fibroblast growth factor receptor (FGFR).Fórmula:C23H26N6O3SPureza:99.54%Forma y color:SolidPeso molecular:466.56FGFR2-IN-3
CAS:FGFR2-IN-3 is an orally active selective FGFR2 inhibitor[1].Fórmula:C28H24FN7O2Pureza:99.24%Forma y color:SoildPeso molecular:509.53Ref: TM-T60185
1mg95,00€5mg202,00€10mg298,00€25mg630,00€50mg938,00€100mg1.264,00€1mL*10mM (DMSO)224,00€Orantinib
CAS:Orantinib (NSC 702827) , a excellent effective against PDGFR autophosphorylation with Ki of 8 nM, also highly inhibits Flk-1 and FGFR1 trans-phosphorylation.Fórmula:C18H18N2O3Pureza:100% - 98.01%Forma y color:SolidPeso molecular:310.35Pemigatinib
CAS:Pemigatinib (INCB054828) is an orally active, selective inhibitor of FGFR(IC50s of 0.4 nM, 0.5 nM, 1.2 nM, 30 nM for FGFR1, FGFR2, FGFR3, FGFR4, respectively).Fórmula:C24H27F2N5O4Pureza:98.15% - 99.95%Forma y color:SolidPeso molecular:487.5LC-MB12
CAS:LC-MB12 is a PROTAC FGFR2 compound that degrades FGFR2 and can be used to study gastric cancer.Fórmula:C43H44Cl2N10O8Pureza:99.16%Forma y color:SolidPeso molecular:899.78S49076 HCl
CAS:S49076 HCl (S-49076 Hydrochloride) is an effective inhibitor of MET, AXL/MER, and FGFR1/2/3.Fórmula:C22H18ClN3O5Pureza:98%Forma y color:SolidPeso molecular:439.85Infigratinib phosphate
CAS:Infigratinib phosphate (BGJ-398 phosphate) is an effective inhibitor of the FGFR family (IC50: 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, andFórmula:C26H34Cl2N7O7PPureza:99.24% - 99.6%Forma y color:SolidPeso molecular:658.47Dovitinib
CAS:Dovitinib is an orally active, multi-targeted tyrosine kinase (RTK) inhibitor with anti-tumor effects.Cost-effective and quality-assured.Fórmula:C21H21FN6OPureza:99.66% - 99.78%Forma y color:SolidPeso molecular:392.43Ref: TM-T6289
5mg47,00€10mg70,00€25mg126,00€50mg202,00€100mg328,00€200mg490,00€500mg783,00€1mL*10mM (DMSO)50,00€Gunagratinib
CAS:Gunagratinib (ICP-192) is a pan-FGFR inhibitor, useful in research on FGFR-related diseases.Fórmula:C22H25N5O4Pureza:99.68%Forma y color:SolidPeso molecular:423.47BO-264
CAS:BO-264 is a highly potent and orally active inhibitor of transforming acidic coiled-coil 3 (TACC3, IC50 of 188 nM and a Kd of 1.5 nM).Fórmula:C18H19N5O3Pureza:98.03% - 99.81%Forma y color:SolidPeso molecular:353.38CHIR-98014
CAS:CHIR-98014 (CT98014) is a selective GSK3 inhibitor; potentiate insulin activation of glucose transport and utilization in vitro and in vivo.Fórmula:C20H17Cl2N9O2Pureza:97.25% - 99.41%Forma y color:SolidPeso molecular:486.31Lucitanib
CAS:Lucitanib (E-3810) is a VEGFR/FGFR inhibitor targeting VEGFR1-3 and FGFR1-2 with IC50s 7-82.5 nM.Fórmula:C26H25N3O4Pureza:96.13%Forma y color:SolidPeso molecular:443.49Ref: TM-T15185
1mg48,00€2mg63,00€5mg87,00€10mg144,00€25mg269,00€50mg487,00€100mg710,00€1mL*10mM (DMSO)96,00€
