Receptor del factor de crecimiento de fibroblastos (FGFR)
Los inhibidores de FGFR (receptores del factor de crecimiento de fibroblastos) son terapias dirigidas que bloquean la actividad de los FGFR, los cuales están involucrados en la proliferación celular, diferenciación y angiogénesis. La señalización de FGFR contribuye a la formación de nuevos vasos sanguíneos en los tumores, promoviendo su crecimiento y supervivencia. Inhibir FGFR puede, por lo tanto, reducir la angiogénesis y la progresión tumoral. En CymitQuimica, ofrecemos una gama de inhibidores de FGFR de alta calidad para apoyar su investigación en cáncer, biología del desarrollo y angiogénesis.
Productos de "Receptor del factor de crecimiento de fibroblastos (FGFR)"
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FGFR3-IN-7
CAS:FGFR3-IN-7 is a potent, selective inhibitor of FGFR 3, demonstrating an IC50 value of less than 350 nM , and is utilized in cancer research [1].Fórmula:C25H24FN9OPureza:98%Forma y color:SolidPeso molecular:485.52SU 5402
CAS:SU 5402 is a potent multi-targeted receptor tyrosine kinase inhibitor with IC50 of 20 nM, 30 nM, and 510 nM for VEGFR2, FGFR1, and PDGF-Rβ, respectively.Fórmula:C17H16N2O3Pureza:98.91% - 99.64%Forma y color:Yellow-Green SolidPeso molecular:296.32Fazpilodemab
CAS:Fazpilodemab (BFKB8488A) is a humanized agonistic bispecific antibody that targets fibroblast growth factor receptor 1c (FGFR1c) and Klothoβ.Pureza:98%Forma y color:LiquidAZD4547
CAS:AZD4547 is an FGFR family inhibitor, and is able to act on FGFR1, FGFR2, FGFR3 and FGFR4. IC50:165 nM).Cost-effective and quality-assured.Fórmula:C26H33N5O3Pureza:99.37% - 99.88%Forma y color:SolidPeso molecular:463.57Ref: TM-T1948
2mg39,00€5mg49,00€10mg63,00€25mg88,00€50mg113,00€100mg156,00€200mg219,00€500mg366,00€1mL*10mM (DMSO)55,00€PF 477736
CAS:PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (Fórmula:C22H25N7O2Pureza:98.34% - 99.62%Forma y color:SolidPeso molecular:419.48FGFR1 inhibitor-9
FGFR1 inhibitor-9 (Compound 7) is an FGFR1 inhibitor with potent binding affinity, exhibiting an IC50 of 0.85 nM.Fórmula:C27H20ClNO5Pureza:98%Forma y color:SolidPeso molecular:473.9Infigratinib
CAS:Infigratinib (NVP-BGJ398) (BGJ398) is an orally bioavailable pan FGFR inhibitor (IC50: 0.9/1.4/1 nM for FGFR1/2/3), >40-fold selective for FGFR versus FGFR4 andFórmula:C26H31Cl2N7O3Pureza:98% - 98.97%Forma y color:SolidPeso molecular:560.48FGFR-IN-15
FGFR-IN-15 (compound 18i) acts as a pan-FGFR inhibitor, exhibiting potent inhibitory activity against FGFR1-4.Fórmula:C22H23N5O5SForma y color:SolidPeso molecular:469.51Heparan Sulfate
CAS:Heparan sulfate is a natural product, a linear polysaccharide. Heparan sulfate occurs as a proteoglycan (HSPG). Cost effective and quality assured.Fórmula:C12H19NO20S3(monomer)Pureza:98%Forma y color:SolidPeso molecular:593.47(monomer)SU4984
CAS:SU4984 is a cell-permeable, ATP-competitive and reversible inhibitor of the fibroblast growth factor receptor 1 (FGFR1).Fórmula:C20H19N3O2Pureza:100%Forma y color:SolidPeso molecular:333.38FGFR1 inhibitor-10
CAS:FGFR1 inhibitor-10 (Compound 4i), with an IC50 of 28 nM, effectively inhibits FGFR1 phosphorylation.Fórmula:C26H30F3N7O2SPureza:98%Forma y color:SolidPeso molecular:561.62PD168393
CAS:PD168393 is an irreversible EGFR inhibitor (IC50: 0.70 nM), irreversibly alkylate Cys-773; inactive against PKC, FGFR, PDGFR, and insulin.Fórmula:C17H13BrN4OPureza:99.13% - 99.7%Forma y color:SolidPeso molecular:369.22Ref: TM-T6932
1mg39,00€2mg49,00€5mg66,00€10mg89,00€25mg155,00€50mg222,00€100mg310,00€1mL*10mM (DMSO)56,00€PP58
CAS:PP58 is an inhibitor of PDGFR, FGFR and Src family.Fórmula:C22H19Cl2N5O2Pureza:99.21%Forma y color:SolidPeso molecular:456.32FGFR1 inhibitor 7
FGFR1 Inhibitor 7 (compound 5), a potent FGFR1 tyrosine kinase inhibitor, exhibits an IC50 of 0.33 nM against its target and demonstrates broad-spectrumFórmula:C25H16ClNO4Pureza:98%Forma y color:SolidPeso molecular:429.85PD-161570
CAS:Fórmula:C26H35Cl2N7OPureza:>98.0%(HPLC)Forma y color:White to Light yellow powder to crystalPeso molecular:532.51FGFR3-IN-6
CAS:FGFR3-IN-6 is a potent, selective inhibitor of FGFR 3, exhibiting an IC50 value of less than 350 nM , and is utilized in cancer research [1].Fórmula:C25H23FN8O2Pureza:98%Forma y color:SolidPeso molecular:486.5FGFR1 inhibitor-16
CAS:FGFR1inhibitor-16 (Compound 89) functions as an FGFR1 inhibitor, demonstrating an inhibition rate of 53.00% at a concentration of 50 μM and 24.95% at 10 μM. It is utilized in tumor research.Fórmula:C16H9N5O3SForma y color:SolidPeso molecular:351.339Dovitinib lactate hydrate
CAS:Dovitinib lactate hydrate (TKI258) is the Lactate of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit).Fórmula:C24H27FN6O4Pureza:99.82%Forma y color:SolidPeso molecular:482.51Roblitinib
CAS:Roblitinib (FGF-401), an FGFR4 inhibitor, potentially blocks tumor growth by halting cell proliferation and survival.Fórmula:C25H30N8O4Pureza:97.27% - 99%Forma y color:SolidPeso molecular:506.56Ref: TM-T4235
1mg58,00€2mg84,00€5mg103,00€10mg169,00€25mg306,00€50mg535,00€100mg752,00€500mg1.586,00€Nintedanib
CAS:Fórmula:C31H33N5O4Pureza:>95.0%(T)(HPLC)Forma y color:White to Yellow to Yellow green powder to crystalPeso molecular:539.64
