ALK
Los inhibidores de ALK son compuestos que específicamente atacan e inhiben la quinasa del linfoma anaplásico (ALK), una tirosina quinasa receptora involucrada en el desarrollo y progresión de ciertos tipos de cáncer, incluyendo el cáncer de pulmón de células no pequeñas y el neuroblastoma. Al inhibir ALK, estos compuestos bloquean las vías de señalización que promueven el crecimiento y la supervivencia de las células tumorales. En CymitQuimica, ofrecemos inhibidores de ALK para apoyar su investigación en oncología, terapias dirigidas contra el cáncer y transducción de señales.
Productos de "ALK"
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Alectinib hydrochloride
CAS:Alectinib hydrochloride (RO5424802 Hydrochloride) is a selective, and orally available inhibitor of ALK( IC50 : 1.9 nM)Fórmula:C30H35ClN4O2Pureza:99.61% - 99.96%Forma y color:SolidPeso molecular:519.08LDN193189
CAS:LDN193189 blocks BMP signaling by inhibiting ALK2/3; IC50: ALK1/2/3/6 = 0.8/0.8/5.3/16.7 nM.Fórmula:C25H22N6Pureza:98% - 99.86%Forma y color:SolidPeso molecular:406.48EW-7195
CAS:EW-7195 inhibits ALK5/TGFβR1 (>300x selective over p38α) with 4.83 nM IC50, blocking TGF-β1 signaling, EMT, and breast cancer lung metastasis.Fórmula:C23H18N8Pureza:98.76%Forma y color:SolidPeso molecular:406.44Ref: TM-T38752
1mg131,00€2mg187,00€5mg311,00€10mg535,00€25mg1.064,00€50mg1.738,00€100mg2.745,00€1mL*10mM (DMSO)344,00€OD36
CAS:OD36: Potent RIPK2 inhibitor, IC50=5.3 nM; hinders ALK2 signaling and osteogenesis, KD=37 nM; targets ALK2 ATP pocket.Fórmula:C16H15ClN4O2Pureza:99.89%Forma y color:SolidPeso molecular:330.77DMH-1
CAS:DMH-1 is a BMP inhibitor that inhibits ALK1, ALK2, ALK3 and ALK6. DMH-1 promotes pluripotent stem cell differentiation. Cost-effective and quality-assured.Fórmula:C24H20N4OPureza:98% - 99.92%Forma y color:SolidPeso molecular:380.44CH5424802 analog
CAS:CH5424802 analog is a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant.Fórmula:C28H30N4O2Pureza:98.96%Forma y color:SolidPeso molecular:454.56Ref: TM-T9224
1mg131,00€5mg286,00€10mg430,00€25mg710,00€50mg998,00€100mg1.349,00€1mL*10mM (DMSO)343,00€(-)-Cevimeline hydrochloride hemihydrate
(-)-Cevimeline HCl hemihydrate, a muscarinic agonist, treats Sjogren's xerostomia. Quick absorption, species-dependent metabolism.Fórmula:C10H19ClNO1·5SPureza:98%Forma y color:SolidPeso molecular:244.78ZX-29
CAS:ZX-29: Strong ALK inhibitor; IC50 - ALK 2.1 nM, L1196M 1.3 nM, G1202R 3.9 nM; triggers autophagy; anti-cancer.Fórmula:C23H28ClN7O3SPureza:98.32%Forma y color:SolidPeso molecular:518.03Ref: TM-T13416
1mg92,00€5mg230,00€10mg364,00€25mg620,00€50mg848,00€100mg1.121,00€1mL*10mM (DMSO)296,00€CEP-28122 mesylate salt (1022958-60-6 free base)
CEP-28122 mesylate salt (1022958-60-6 free base) is a highly selective orally active ALK inhibitor (IC50: 1.9 nM in an enzyme-based TRF assay).Fórmula:C29H39ClN6O6SPureza:99.79%Forma y color:SolidPeso molecular:635.17SB-505124 hydrochloride
CAS:SB-505124 hydrochloride (SB505124 hydrochloride) is a TGF-β type I receptor (ALK4, ALK5, ALK7) inhibitor for the study of colorectal cancer.Fórmula:C20H22ClN3O2Pureza:98.71%Forma y color:SolidPeso molecular:371.86KER047
CAS:ALK2-IN-4, a highly effective ALK2 inhibitor.Fórmula:C26H30FN7OPureza:100% - 98.49%Forma y color:SolidPeso molecular:475.56Ref: TM-T39764
1mg96,00€5mg227,00€10mg369,00€25mg753,00€50mg1.074,00€100mg1.644,00€1mL*10mM (DMSO)250,00€AZD-3463
CAS:AZD-3463 (ALK/IGF1R inhibitor) , an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency.Fórmula:C24H25ClN6OPureza:99.13%Forma y color:SolidPeso molecular:448.95ALKBH5-IN-5
CAS:ALKBH5-IN-5 is a highly selective, potent and covalently binding ALKBH5 inhibitor that alters m6A levels on mRNA, induces apoptosis, antitumo.Fórmula:C13H13NO3Pureza:99.54%Forma y color:SoildPeso molecular:231.25Ref: TM-T203011
1mg185,00€5mg459,00€10mg657,00€25mg1.026,00€50mg1.415,00€100mg1.872,00€200mg2.555,00€RepSox
CAS:RepSox (ALK5 Inhibitor II) is a TGFβR-1/ALK5 inhibitor that selectively inhibits the binding of ATP to ALK5 and the autophosphorylation of ALK5 (IC50=23/4 nM).Fórmula:C17H13N5Pureza:98.8% - 99.62%Forma y color:SolidPeso molecular:287.32Ref: TM-T6337
1mg35,00€2mg48,00€5mg66,00€10mg85,00€25mg123,00€50mg172,00€100mg255,00€500mg630,00€1mL*10mM (DMSO)72,00€BIBF0775
CAS:BIBF0775 is a selective TGFβ type I receptor (Alk5) inhibitor (IC50: 34 nM).Fórmula:C31H34N4O2Pureza:99.02% - 99.45%Forma y color:SolidPeso molecular:494.63Ref: TM-T5197
1mg43,00€5mg96,00€10mg135,00€25mg215,00€50mg304,00€100mg437,00€200mg610,00€1mL*10mM (DMSO)96,00€HG-14-10-04
CAS:HG-14-10-04 is a potent and specific ALK inhibitor.Fórmula:C29H34ClN7OPureza:100% - 99.75%Forma y color:SolidPeso molecular:532.08A 77-01
CAS:A 77-01 is a potent inhibitor of TGF-(beta) type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM.Fórmula:C18H14N4Pureza:98.82% - ≥95%Forma y color:SolidPeso molecular:286.33INCB-000928
CAS:Zilurgisertib (INCB-000928) is a selective and potent ALK 2 inhibitor for the study of cancer and MF anemia.Fórmula:C30H38N4O3Pureza:98.93%Forma y color:SolidPeso molecular:502.65SM 16
CAS:SM 16 is a ALK5/ALK4 kinase inhibitor (Ki: 10/1.5 nM).Fórmula:C25H26N4O3Pureza:99.72%Forma y color:SolidPeso molecular:430.5AZ12601011
CAS:AZ12601011 is a TGFBR1 kinase inhibitor that inhibits the growth of breast tumors.Fórmula:C19H15N5Pureza:98.81%Forma y color:SolidPeso molecular:313.36Ref: TM-T10426
1mg99,00€5mg235,00€10mg376,00€25mg728,00€50mg1.093,00€100mg1.510,00€1mL*10mM (DMSO)259,00€
