Receptor sigma
Los receptores sigma son sitios de unión únicos que, a diferencia de los GPCR tradicionales, no encajan en las categorías clásicas de proteínas receptoras. Están involucrados en la modulación de los sistemas de neurotransmisores y se han implicado en varios trastornos neurológicos y psiquiátricos. Los receptores sigma también están asociados con la supervivencia celular, y sus ligandos se están explorando para aplicaciones terapéuticas en neuroprotección, cáncer y manejo del dolor. En CymitQuimica, ofrecemos una selección de moduladores de receptores sigma de alta calidad para apoyar su investigación en neurociencia, oncología y biología de receptores.
Productos de "Receptor sigma"
Ordenar por
Blarcamesine
CAS:Blarcamesine (AVex-73) is a muscarinic M1 agonist potentially for the treatment of Alzheimer's disease.Fórmula:C19H23NOPureza:99.87%Forma y color:SolidPeso molecular:281.39BD-1047
CAS:BD-1047 is a selective functional antagonist of sigma receptors. It can alleviate climbing behavior induced by Apomorphine and head twitching caused by Phencyclidine.Fórmula:C13H20Cl2N2Forma y color:SolidPeso molecular:275.217Amitriptyline
CAS:Amitriptyline: a tricyclic antidepressant used for depression and neuropathic pain.Fórmula:C20H23NPureza:98.24% - 99.64%Forma y color:Crystals SolidPeso molecular:277.4Opipramol
CAS:Opipramol (Ensidon) is a compound with antidepressant activity, a sigma (σ) receptor agonist, and anxiolytic activity.Fórmula:C23H29N3OPureza:99.84% - 99.98%Forma y color:SolidPeso molecular:363.5Sigma-1 receptor antagonist 3
CAS:Sigma-1 receptor antagonist 3 is a more potent and selective antagonist of Sigma-1 (σ1) receptor (Ki = 1.14 nM) than σ2 receptor(Ki = 1239 nM).Fórmula:C19H23ClFN3OPureza:100%Forma y color:SolidPeso molecular:363.86Pre-084
CAS:Pre-084 is a high affinity, selective σ1 agonist.Fórmula:C19H28ClNO3Pureza:99.91%Forma y color:SolidPeso molecular:353.88Sigma-LIGAND-1
CAS:Sigma-LIGAND-1 is a selective Sigma Receptor ligand with an IC50s of 16 nM, 19 nM at the DTG site and the PPP site, respectively.Fórmula:C27H33NO4Pureza:100%Forma y color:SolidPeso molecular:435.56Ref: TM-T13510
1mg64,00€5mg149,00€10mg215,00€25mg335,00€50mg452,00€100mg620,00€200mg835,00€1mL*10mM (DMSO)172,00€KB-5492 free base
CAS:KB-5492 free base is an antiulcer agent that inhibits sigma receptors and can be used to study gastric lesions and gastric secretion.Fórmula:C23H30N2O6Pureza:97.72% - 99.07%Forma y color:SolidPeso molecular:430.49Ref: TM-T62396
2mg42,00€5mg62,00€10mg87,00€25mg126,00€50mg177,00€100mg263,00€500mg647,00€1mL*10mM (DMSO)67,00€SARS-CoV-2-IN-57
CAS:SARS-CoV-2-IN-57 (compound (+)-R-26) is a potent inhibitor of SARS-CoV-2 with an IC50 of 80 nM and demonstrates high affinity for the Sigma Receptor, exhibitingFórmula:C23H37N3OPureza:98%Forma y color:SolidPeso molecular:371.56UKH-1114
CAS:UKH-1114 is a potent σ2 receptor/Tmem97 agonist with a Ki value of 46 nM, demonstrating antinociceptive effects against mechanical hypersensitivity. This compound alleviates mechanical hypersensitivity in mice caused by nerve injury without inducing motor impairment and is a promising candidate for neuropathic pain research.Fórmula:C22H24F3NOForma y color:SolidPeso molecular:375.43AB21 oxalate
AB21 oxalate, a potent and selective S1R antagonist, exhibits binding affinities (Kis) of 13 nM and 102 nM for S1R and S2R, respectively.Fórmula:C25H30N2O5Pureza:98%Forma y color:SolidPeso molecular:438.52BD1063 dhydrochloride
CAS:BD1063 dhydrochloride is a potent and selective sigma 1(σ1) receptor antagonist(Ki = 9 nM).Fórmula:C13H20Cl4N2Pureza:99.52% - ≥95%Forma y color:SolidPeso molecular:346.12Ref: TM-T7488
2mg48,00€5mg72,00€10mg90,00€25mg187,00€50mg339,00€100mg499,00€200mg702,00€500mg1.074,00€Sigma-1 receptor antagonist 4
Sigma-1 receptor antagonist 4 (Compound 32) is a potent σ1R antagonist that significantly enhances morphine's analgesic effects and reverses morphine-inducedFórmula:C22H26N2OForma y color:SolidPeso molecular:334.45KB-5492 FA
KB-5492 FA is a selective sigma receptor inhibitor with antiulcerogenic effects.CAS 번호128-52-56-8Fórmula:C24H32N2O8Pureza:98.54%Forma y color:SolidPeso molecular:476.52PD 144418
CAS:PD 144418 displays potential antipsychotic activity.Fórmula:C18H22N2OPureza:98%Forma y color:SolidPeso molecular:282.38Sigma-1 receptor antagonist 1
CAS:Sigma-1 receptor antagonist 1 is an effective and selective antagonist of sigma-1 receptor.Fórmula:C19H23Cl2N3OPureza:99.81%Forma y color:SolidPeso molecular:380.31S1RA
CAS:S1RA (E-52862)(E-52862) is a potent, selective antagonist of the sigma-1 receptor (σ1R, Ki=17 nM), demonstrating significant selectivity over the sigma-2Fórmula:C20H23N3O2Pureza:99.45%Forma y color:SolidPeso molecular:337.42BMY-14802 hydrochloride
CAS:BMY-14802 hydrochloride (BMS 181100 hydrochloride) is a selective antagonist of σ receptor (IC50 = 112 nM) with antipsychotic effects.Fórmula:C18H23ClF2N4OPureza:98.64%Forma y color:SolidPeso molecular:384.85Sigma-1 receptor antagonist 2
CAS:Sigma-1 receptor antagonist 2 is a more potent and selective antagonist of sigma 1 receptor (σ1 R, Ki = 3.88 nM) than σ2 receptor (Ki = 1288 nM).Fórmula:C20H26ClN3O2Pureza:99.52%Forma y color:SolidPeso molecular:375.89Ref: TM-T12911
1mg64,00€5mg145,00€10mg235,00€25mg394,00€50mg562,00€100mg758,00€200mg1.017,00€1mL*10mM (DMSO)160,00€Ditolylguanidine
CAS:Ditolylguanidine (Di-o-tolylguanidine) is an agonist of sigma receptor (σ1/σ2 receptor).Fórmula:C15H17N3Pureza:98.42%Forma y color:White To Pinkish Solid PowderPeso molecular:239.32
