mTOR
Los inhibidores de mTOR son compuestos que inhiben la actividad de la Proteína diana de la rapamicina en mamíferos (mTOR), un regulador central del crecimiento celular, la proliferación, el metabolismo y la supervivencia. La vía de mTOR se altera con frecuencia en el cáncer y otras enfermedades, lo que convierte a mTOR en un objetivo crítico para la intervención terapéutica. Los inhibidores de mTOR se utilizan ampliamente en la investigación relacionada con el cáncer, el envejecimiento y los trastornos metabólicos. En CymitQuimica, ofrecemos una variedad de inhibidores de mTOR para apoyar su investigación en transducción de señales, oncología y desarrollo terapéutico.
Productos de "mTOR"
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Torkinib
CAS:Torkinib (PP 242) (PP 242) is a selective and ATP-competitive mTOR inhibitor (IC50: 8 nM). It also inhibits mTORC1/2 (IC50s: 30/58 nM).Fórmula:C16H16N6OPureza:99.11%Forma y color:SolidPeso molecular:308.34Ref: TM-T2414
5mg57,00€10mg74,00€25mg96,00€50mg136,00€100mg227,00€200mg338,00€500mg560,00€1mL*10mM (DMSO)63,00€3BDO
CAS:3BDO is a new mTOR activator. 3BDO inhibits autophagy.Fórmula:C18H17NO5Pureza:96.00%Forma y color:SolidPeso molecular:327.33Ref: TM-T14033
2mg47,00€5mg69,00€10mg97,00€25mg208,00€50mg331,00€100mg520,00€200mg777,00€500mg1.188,00€1mL*10mM (DMSO)74,00€ETP-45658
CAS:ETP-45658 (ETP45658) is a PI 3-kinase inhibitor (IC50 values are 22, 30, 129 and 710 nM for PI 3-Kα, PI 3-Kδ, PI 3-Kβ and PI 3-Kγ respectively).Fórmula:C16H17N5O2Pureza:99.13%Forma y color:SolidPeso molecular:311.34Ref: TM-T25399
1mg52,00€5mg111,00€10mg175,00€25mg316,00€50mg512,00€100mg747,00€1mL*10mM (DMSO)124,00€MKC-1
CAS:MKC-1 (Ro-31-7453) is an oral bisindolylmaleimide inhibitor that disrupts tubulin polymerization, potentially halting cancer cell division.Fórmula:C22H16N4O4Pureza:98.38% - 99.46%Forma y color:SolidPeso molecular:400.39Ref: TM-T9831
1mg57,00€5mg125,00€10mg177,00€25mg309,00€50mg445,00€100mg622,00€500mgA consultar1mL*10mM (DMSO)134,00€KU-0063794
CAS:KU-0063794 is a potent and highly specific dual-mTOR inhibitor of mTORC1 and mTORC2.Fórmula:C25H31N5O4Pureza:100% - 98.35%Forma y color:SolidPeso molecular:465.54PI-103
CAS:PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2/3/3/15/30/23 nM for p110α/β/δ/γ, mTOR, and DNA-PK).Fórmula:C19H16N4O3Pureza:96.59% - 99.3%Forma y color:SolidPeso molecular:348.36VS-5584
CAS:VS-5584 (SB2343) is a pan-PI3K/mTOR kinase inhibitor.Fórmula:C17H22N8OPureza:97.82% - 99.54%Forma y color:SolidPeso molecular:354.41DIM-C-pPhOH
CAS:CDIM8 (DIM-C-pPhOH) opposes NR4A1, halts TGF-β breast cancer migration, induces ROS/ER stress, and mimics Nur77 RNAi in pancreatic cancer.Fórmula:C23H18N2OPureza:98.61%Forma y color:SolidPeso molecular:338.4Ref: TM-T4400
2mg44,00€5mg65,00€10mg84,00€25mg153,00€50mg227,00€100mg376,00€200mg495,00€1mL*10mM (DMSO)59,00€Bimiralisib
CAS:Bimiralisib (PI3K-IN-2) is an orally bioavailable pan inhibitor of PI3K and inhibitor of the mTOR, with potential antineoplastic activity.Fórmula:C17H20F3N7O2Pureza:97.58% - 98.92%Forma y color:SolidPeso molecular:411.38PI3K/mTOR Inhibitor-2
CAS:Potent PI3K/mTOR Inhibitor-2 targets PI3Kα/β/δ/γ & mTOR (IC50: 3.4, 34, 16,1, 4.7 nM); exhibits antitumor effects.Fórmula:C20H13ClF2N4O4SPureza:96.16%Forma y color:SolidPeso molecular:478.86Ref: TM-T12459
1mg58,00€5mg145,00€10mg226,00€25mg378,00€50mg540,00€100mg730,00€200mg938,00€1mL*10mM (DMSO)153,00€Dihydromyricetin
CAS:Dihydromyricetin, a flavonoid from Ampelopsis, is an antioxidant that blocks dihydropyrimidinase (IC50: 48 μM) and activates autophagy via mTOR inhibition.Fórmula:C15H12O8Pureza:96.68% - 98.13%Forma y color:SolidPeso molecular:320.25WAY-600
CAS:WAY-600 is a potent, ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM; blocks mTORC1/P-S6K(T389) and mTORC2/P-AKT(S473) but not P-AKT(T308).Fórmula:C28H30N8OPureza:99.63%Forma y color:SolidPeso molecular:494.59Ref: TM-T6730
1mg38,00€2mg64,00€5mg97,00€10mg140,00€25mg245,00€50mg363,00€100mg507,00€500mgA consultar1mL*10mM (DMSO)111,00€mTORC1-IN-1
mTORC1-IN-1 (T1), a rapamycin homologue (rapalog) and selective inhibitor of mTORC1, controls cell growth and metabolism, with implications in various diseasesPureza:98%Forma y color:Odour SolidmTOR inhibitor-12
mTOR inhibitor-12 (Compound 11), a selective, brain-penetrant mTOR inhibitor, exhibits no genotoxicity risk and is utilized in research pertaining to centralFórmula:C19H24N6O2SPureza:98%Forma y color:SolidPeso molecular:400.5D-α-Hydroxyglutaric acid disodium
CAS:D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-Hydroxyglutarate) is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases with Ki of 0.628 mM.Fórmula:C5H6Na2O5Pureza:98%Forma y color:SolidPeso molecular:192.08Torin 1
CAS:Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K.Fórmula:C35H28F3N5O2Pureza:98.3% - 99.38%Forma y color:SolidPeso molecular:607.62ElteN378
CAS:ElteN378: potently inhibits FKBP12 (Ki=0.5 nM), low weight, similar affinity to Rapamycin.Fórmula:C23H26N2O3Pureza:98.09%Forma y color:SolidPeso molecular:378.46Ref: TM-T9950
1mg170,00€5mg376,00€10mg557,00€25mg895,00€50mg1.216,00€100mg1.691,00€200mg2.262,00€1mL*10mM (DMSO)329,00€AZD 3147
CAS:AZD 3147 inhibits mTORC1 (40.7 nM), mTORC2 (5.75 nM), and PI3Kα/β/δ/γ (912/5495/9333/6310 nM IC50s).Fórmula:C24H31N5O4S2Pureza:98.34%Forma y color:SolidPeso molecular:517.66Ref: TM-T36200
1mg97,00€5mg210,00€10mg338,00€25mg582,00€50mg777,00€100mg1.074,00€1mL*10mM (DMSO)273,00€Zotarolimus
CAS:Zotarolimus (ABT-578), an analogue of rapamycin, inhibits FKBP-12 (IC50= 2.8 nM).Fórmula:C52H79N5O12Pureza:95% - ≥98%Forma y color:SolidPeso molecular:966.21Ref: TM-T6033
1mg66,00€2mg96,00€5mg144,00€10mg225,00€25mg393,00€50mg565,00€100mg818,00€1mL*10mM (DMSO)239,00€mTOR inhibitor-2
CAS:mTOR inhibitor-2 is an inhibitor of selective and oral mTOR (IC50 of 7 nM).Fórmula:C23H21N7OPureza:98%Forma y color:SolidPeso molecular:411.46
