Señalización citoesquelética
Los inhibidores de la señalización del citoesqueleto son compuestos que interrumpen las vías de señalización que regulan el citoesqueleto, crucial para la forma celular, la motilidad, la división y el transporte intracelular. Estos inhibidores se utilizan para estudiar la dinámica de las proteínas del citoesqueleto, como la actina y la tubulina, y su papel en procesos como la migración celular, la adhesión y la metástasis del cáncer. Los inhibidores de la señalización del citoesqueleto son valiosos en la investigación sobre biología celular, cáncer y neurobiología. En CymitQuimica, ofrecemos una amplia gama de inhibidores de la señalización del citoesqueleto de alta calidad para apoyar su investigación en estas áreas.
Productos de "Señalización citoesquelética"
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αvβ6-IN-1
αvβ6-IN-1 (compound 28) is an effective orally active inhibitor of αvβ6 integrin (αvβ6integrin), with a pIC50 value of 8.1. This compound shows potential for research in idiopathic pulmonary fibrosis.Fórmula:C25H32F2N4O3Forma y color:SolidPeso molecular:474.5416-38-Thymosin β4 (cattle) (TFA)
Thymosin β4 (cattle) TFA is a high-affinity activator of MLCK that operates independently of Ca2+ [1].Fórmula:C120H205F3N32O43Pureza:98%Forma y color:SolidPeso molecular:2841.1K858 (Racemic)
CAS:K858 Racemic (K858) is a selective mitotic kinesin Eg5 inhibitor which acts in an ATP-noncompetitive manner.Fórmula:C13H15N3O2SPureza:100%Forma y color:SolidPeso molecular:277.34AZ13705339
CAS:AZ13705339 is an effective inhibitor of PAK1 with an IC50 of 0.33 nM and a Kd of 0.28 nM.Fórmula:C33H36FN7O3SPureza:98.57%Forma y color:SolidPeso molecular:629.75FAK-IN-7
CAS:FAK-IN-7 has potential antiproliferative activity and is a FAK inhibitor.Fórmula:C16H13N3OSPureza:98.2%Forma y color:SolidPeso molecular:295.36AJH-836
CAS:AJH-836 is a compound that activates Munc13-1 and PKC ε/α, demonstrating a dissociation constant (Kd) of 4.5 nM for PKCα, and facilitates the translocation ofFórmula:C22H38O5Pureza:98%Forma y color:SolidPeso molecular:382.5310-Deacetyltaxol
CAS:10-Deacetyltaxol (10-DAT) is extracted from Taxus brevifolia barks.Fórmula:C45H49NO13Pureza:94.63% - 99.93%Forma y color:SolidPeso molecular:811.87Tadocizumab
CAS:Tadocizumab (C4G1) is a humanized monoclonal antibody targeting integrin αIIbβ3 with antiplatelet and antithrombotic effects.Forma y color:LiquidKNK437
CAS:KNK437 (Heat Shock Protein Inhibitor I), a pan-HSP inhibitor, suppresses the synthesis of inducible HSPs(HSP105, HSP72, and HSP40).Fórmula:C13H11NO4Pureza:98.90%Forma y color:SolidPeso molecular:245.23PKC-IN-1
CAS:PKC-IN-1 is an ATP-competitive and reversible conventional PKC enzymes inhibitor (PKCα, PKCβI, PKCβII, PKCθ, PKCγ, PKC mu and PKCε with IC50s of 2.3, 8.1, 7.6,Fórmula:C25H37FN8O2Pureza:98% - 98.79%Forma y color:SolidPeso molecular:500.61Gamitrinib TPP
CAS:Gamitrinib TPP targets mitochondrial HSP90, inhibiting cancer, and blocks mitochondrial matrix.Fórmula:C52H65N3O8PPureza:98%Forma y color:SolidPeso molecular:891.078API-1
CAS:API-1 (NSC-177223) is a potent inhibitor of Akt. It induces GSK3-dependent, β-TrCP- and FBXW7-mediated Mcl-1 degradation, resulting in induction of apoptosis .Fórmula:C13H15N5O6Pureza:99.07%Forma y color:SolidPeso molecular:337.29Ref: TM-T8969
1mg59,00€5mg125,00€10mg207,00€25mg376,00€50mg562,00€100mg787,00€200mg1.035,00€1mL*10mM (DMSO)133,00€AKT-IN-1
CAS:AKT-IN-1 (AZD-26) is an allosteric AKT inhibitor (IC50: 1.04 μM).Fórmula:C22H21N3OPureza:98.63%Forma y color:SolidPeso molecular:343.42Ref: TM-T4489
1mg113,00€2mg158,00€5mg235,00€10mg400,00€25mg652,00€50mg909,00€100mg1.225,00€1mL*10mM (DMSO)188,00€HSP70/SIRT2-IN-2
CAS:HSP70/SIRT2-IN-2 (Compounds 1a), a dual inhibitor of SIRT2 and HSP70, exhibits an IC50 of 45.1±5.0 μM against SIRT2 and demonstrates antitumor activity [1].Fórmula:C17H13N3S3Pureza:98%Forma y color:SolidPeso molecular:355.5LXH254
CAS:LXH254 is a B/C RAF inhibitor with IC50 values of 0.2 nM and 0.07 nM for inhibiting BRAF and CRAF.Cost-effective and quality-assured.Fórmula:C25H25F3N4O4Pureza:98.3% - 99.92%Forma y color:SolidPeso molecular:502.49Ref: TM-T11898
1mg52,00€5mg122,00€10mg185,00€25mg363,00€50mg567,00€100mg690,00€200mg948,00€500mg1.444,00€1mL*10mM (DMSO)135,00€Debio 0932
CAS:Debio 0932 (CUDC-305) is a Hsp9 inhibitor, apoptosis, and has the advantage of being orally available and cross the BBB for cancers NSCLC and neuroblastoma.Fórmula:C22H30N6O2SPureza:98.98%Forma y color:SolidPeso molecular:442.58AT9283
CAS:AT9283 (J-504568) is an effective multi-targeted inhibitor of JAK2(IC50=1.2 nM) and JAK3(IC50=1.1 nM), Aurora A, Aurora B and Abl(T315I).Fórmula:C19H23N7O2Pureza:99.83% - 99.98%Forma y color:SolidPeso molecular:381.43Ref: TM-T3068
1mg47,00€2mg60,00€5mg95,00€10mg170,00€25mg299,00€50mg499,00€100mg723,00€1mL*10mM (DMSO)97,00€Bisindolylmaleimide III
CAS:Bisindolylmaleimide III is a potent and selective inhibitor of protein kinase C (PKC).Bisindolylmaleimide III selectively interacts with PKCα or ribosomal S6Fórmula:C23H20N4O2Pureza:98.6%Forma y color:SolidPeso molecular:384.43Pifithrin-μ
CAS:Pifithrin-μ (NSC-303580) is an inhibitor of p53 and HSP70, with neuroprotective and antitumor activity.Fórmula:C8H7NO2SPureza:99.33% - 99.79%Forma y color:SolidPeso molecular:181.21KP-23172
CAS:KP-23172 is a inhibitor of PI3-K/Akt pathway.Fórmula:C10H4N6OPureza:98%Forma y color:SolidPeso molecular:224.18
