
NF-κB
Le facteur nucléaire kappa B (NF-κB) est un facteur de transcription qui régule l'expression des gènes impliqués dans les réponses immunitaires, l'inflammation, la survie cellulaire et la prolifération. Le NF-κB est activé en réponse à divers stimuli, y compris les cytokines, les agents pathogènes et les signaux de stress. La dérégulation de la signalisation du NF-κB est associée à des maladies inflammatoires chroniques, au cancer et aux troubles auto-immuns. Chez CymitQuimica, nous offrons une sélection complète de modulateurs de la voie NF-κB pour soutenir vos recherches en inflammation, oncologie et régulation immunitaire.
Produits appartenant à la catégorie "NF-κB"
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Muscone
CAS :Muscone (3-Methylcyclopentadecanone) is an organic compound that is the primary contributor to the odor of musk.Formule :C16H30ODegré de pureté :99.28%Couleur et forme :Colourless Liquid LiquidMasse moléculaire :238.41TBK1-IN-1
TBK1-IN-1 is a TANK-binding kinase 1 inhibitor with anticancer activity.TBK1-IN-1 inhibits the expression of TBK1 downstream target genes, cxcl10 and ifnβ.Formule :C27H37N7O2Degré de pureté :99.91%Couleur et forme :SolidMasse moléculaire :491.63Zingerone
CAS :Zingerone (Vanillylacetone) is a nontoxic methoxyphenol isolated from Zingiber officinale with potent anti-inflammatory, antidiabetic and anti-tumor properties.Formule :C11H14O3Degré de pureté :99.38% - 99.85%Couleur et forme :Clear Slightly Yellow LiquidMasse moléculaire :194.23PROTAC IRAK4 degrader-8
CAS :PROTAC IRAK4 Degrader-8 (Compound 2) is a PROTAC designed to target IRAK4 with an IC50 of 15.5 nM [1].Formule :C43H50ClF2N11O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :874.38WAY-169916
CAS :WAY-169916 inhibits ER by blocking NF-kB activity, lacks estrogenic effects.Formule :C17H13F3N2O2Degré de pureté :98.63% - 98.64%Couleur et forme :SolidMasse moléculaire :334.29Ref: TM-T8981
2mg42,00€5mg64,00€10mg97,00€25mg197,00€50mg329,00€100mg475,00€200mg655,00€1mL*10mM (DMSO)94,00€Gue1654
CAS :Gue1654 is an OXE-R inhibitor and cardiomyocyte apoptosis.Gue1654 can be used for the study of cardiovascular diseases.Formule :C23H17N3OS3Degré de pureté :98.02% - 98.31%Couleur et forme :SolidMasse moléculaire :447.6Malachite green oxalate
CAS :Malachite green oxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions.Formule :C23H25N2·C2HO4C2H2O4Couleur et forme :Dark Green Crystals With A Metallic LusterMasse moléculaire :463.51IMD-0354
CAS :IMD-0354 (IKK2 Inhibitor V) is an IKKβ inhibitor and inhibits IκBα phosphorylation in NF-κB pathway.Formule :C15H8ClF6NO2Degré de pureté :99.56% - 99.71%Couleur et forme :SolidMasse moléculaire :383.67Ref: TM-T6141
2mg48,00€5mg66,00€10mg92,00€25mg163,00€50mg221,00€100mg310,00€500mg753,00€1mL*10mM (DMSO)69,00€RIP2 Kinase Inhibitor 3
CAS :RIP2 Kinase Inhibitor 3 is a potent and selective inhibitor of RIP2 with an IC50 of 1 nM.Formule :C19H24N4O3SDegré de pureté :98.28% - 98.35%Couleur et forme :SolidMasse moléculaire :388.48Benzoyloxypaeoniflorin
CAS :Benzoyloxypaeoniflorin, a natural compound, enhances blood flow by inhibiting platelet aggregation and coagulation.Formule :C30H32O13Degré de pureté :97.64% - 98.7%Couleur et forme :SolidMasse moléculaire :600.57Ref: TM-T4S1658
1mg127,00€5mg298,00€10mg432,00€25mg697,00€50mg938,00€100mg1.293,00€1mL*10mM (DMSO)378,00€GSK319347A
CAS :GSK319347A is a dual inhibitor of TBK1 and IKKε that inhibits IKK2 and can be used to study bladder and lung adenocarcinomas.Formule :C22H19N3O5S2Degré de pureté :98.42%Couleur et forme :SolidMasse moléculaire :469.53Ref: TM-T15558
1mg73,00€5mg153,00€10mg255,00€25mg535,00€50mg910,00€100mg1.216,00€1mL*10mM (DMSO)340,00€RIPK1-IN-16
CAS :RIPK1-IN-16 is an orally active, potent RIPK1 inhibitor that mitigates excessive inflammation via inhibition of RIPK1-mediated necroptosis in vivo.Formule :C20H19N5O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :393.46IRAK4-IN-20
CAS :IRAK4-IN-20 is a potent and orally active IRAK4 inhibitor (IC50:3.55 nM).Formule :C22H25F3N4O3Degré de pureté :97.32%Couleur et forme :SolidMasse moléculaire :450.45Asatone
CAS :Asatone from Radix et Rhizoma Asari has anti-inflammatory properties, acting on NF-κB and suppressing p-MAPK pathways (ERK, JNK, p38).Formule :C24H32O8Degré de pureté :99.84% - 99.92%Couleur et forme :SolidMasse moléculaire :448.51Ref: TM-T10383
1mg88,00€5mg202,00€10mg303,00€25mg509,00€50mg725,00€100mg938,00€500mg1.882,00€1mL*10mM (DMSO)198,00€BMS-345541 hydrochloride
CAS :BMS-345541 hydrochloride is a selective IKK inhibitor (IKK2 and IKK1 with IC50 of 0.3 μM and 4 μM,respectively).Formule :C14H18ClN5Degré de pureté :99.13%Couleur et forme :SolidMasse moléculaire :291.78Ref: TM-T8542
1mg40,00€2mg52,00€5mg87,00€10mg126,00€25mg225,00€50mg376,00€100mg563,00€1mL*10mM (DMSO)55,00€Velutin
CAS :Velutin shows the strongest inhibitory effect in NF-κB activation and exhibits the greatest effects in blocking the degradation of inhibitor of NF-κB as well asFormule :C17H14O6Degré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :314.29AZD3264
CAS :AZD3264 is a new type IKK2 inhibitor.Formule :C21H23N5O4SDegré de pureté :98.98% - 99.17%Couleur et forme :SolidMasse moléculaire :441.5Ref: TM-T6771
1mg52,00€2mg70,00€5mg103,00€10mg160,00€25mg311,00€50mg502,00€100mg805,00€500mg1.605,00€1mL*10mM (DMSO)114,00€IMM-H007
CAS :IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expressionFormule :C22H23N5O8Degré de pureté :97.73%Couleur et forme :SolidMasse moléculaire :485.45Ref: TM-T9010
1mg40,00€5mg96,00€10mg135,00€25mg226,00€50mg320,00€100mg434,00€200mg602,00€1mL*10mM (DMSO)131,00€PROTAC IRAK4 degrader-12
CAS :PROTAC IRAK4 degrader-12, a Cereblon ligand-based PROTAC, induces a maximum degradation of IRAK4 in K562 cells at 108.46% with an IC50 value of 4.87 nM. (Structure Note: Pink, IRAK4 Inhibitor; Blue, E3; Black, linker.)Formule :C46H50ClF2N11O6Couleur et forme :SolidMasse moléculaire :926.41BI-69A11
CAS :BI-69A11 is a dual AKT/NFkB inhibitor, increasing colon cancer cell sensitivity to mda-7/IL-24.Formule :C25H16ClN3O2Degré de pureté :96.97%Couleur et forme :SolidMasse moléculaire :425.87Ref: TM-T25150
1mg46,00€2mg57,00€5mg82,00€10mg96,00€25mg180,00€50mg259,00€100mg369,00€1mL*10mM (DMSO)93,00€