NF-κB
Le facteur nucléaire kappa B (NF-κB) est un facteur de transcription qui régule l'expression des gènes impliqués dans les réponses immunitaires, l'inflammation, la survie cellulaire et la prolifération. Le NF-κB est activé en réponse à divers stimuli, y compris les cytokines, les agents pathogènes et les signaux de stress. La dérégulation de la signalisation du NF-κB est associée à des maladies inflammatoires chroniques, au cancer et aux troubles auto-immuns. Chez CymitQuimica, nous offrons une sélection complète de modulateurs de la voie NF-κB pour soutenir vos recherches en inflammation, oncologie et régulation immunitaire.
Produits appartenant à la catégorie "NF-κB"
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Physalin O
CAS :Physalin O has anti-inflammatory properties, binds with GSH, and inhibits NO production.Formule :C28H32O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :528.554JTP 0819958 - HOIPIN-1
JTP-0819958: LUBAC inhibitor, IC50 2.8 μM; blocks NF-kB activation in vitro.Formule :C17H13NaO4Degré de pureté :95.08%Couleur et forme :SolidMasse moléculaire :304.27Parthenolide
CAS :Parthenolide ((-)-Parthenolide) is a natural sesquiterpene lactone that is an NF-κB and HDAC1 inhibitor with anti-inflammatory effect. Cost-effective and quality-assured.Formule :C15H20O3Degré de pureté :99.10% - 99.46%Couleur et forme :White To Pale Yellow Crystalline PowderMasse moléculaire :248.32GSK547
CAS :GSK547 (GSK'547) is a highly selective and potent inhibitor of RIP1 kinase,inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer.Formule :C20H18F2N6ODegré de pureté :99.17%Couleur et forme :SolidMasse moléculaire :396.39Gliotoxin
CAS :Gliotoxin, a mycotoxin, inhibits Wnt pathway, causing apoptosis in mutated colorectal cancer cells and blocks NF-κB by preserving IκB.Formule :C13H14N2O4S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :326.39NLRP3-IN-51
NLRP3-IN-51 (Compound 3q) is an effective activator of the cholinergic anti-inflammatory pathway (CAP). This compound demonstrates potential for treating gouty arthritis as it inhibits the production of IL-1β in THP-1 cells induced by monosodium urate (MSU). Furthermore, NLRP3-IN-51 suppresses the phosphorylation of NF-κBp65 triggered by MSU without impacting the self-cleavage and activation of NLRP3, pro-caspase 1, or the second messenger caspase-1. Therefore, the initial stage of NLRP3 inhibition by NLRP3-IN-51 occurs through the activation of CAP.Couleur et forme :Odour SolidHS-243
CAS :HS-243 is an inhibitor of IRAK-4 and IRAK-1 with IC50s of 20 and 24 nM. HS-243 shows anti-inflammatory and anticancer activity.Formule :C17H16N4O3Degré de pureté :97.34%Couleur et forme :SolidMasse moléculaire :324.33RIP1 kinase inhibitor 4
CAS :RIP1 Kinase Inhibitor 4 (Compound 3) is an effective inhibitor of RIP1K, exhibiting an EC50 of ≤ 1000 nM [1].Formule :C23H23N5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :369.46CHPG sodium salt
CAS :CHPG sodium salt is a selective agonist of mGluR5 and activates the ERK and Akt signaling pathways.Formule :C8H7ClNNaO3Degré de pureté :100%Couleur et forme :SolidMasse moléculaire :223.59IRAK4-IN-8
CAS :IRAK4-IN-8 (VI-177) is an IRAK4 inhibitor for the study of diseases associated with cancer and inflammation.Formule :C23H23F2N7O2SDegré de pureté :99.39%Couleur et forme :SolidMasse moléculaire :499.54Ref: TM-T63388
1mg825,00€2mg1.130,00€5mg1.681,00€10mg2.270,00€25mg3.372,00€50mg4.541,00€100mg6.146,00€Rhynchophylline
CAS :Rhynchophylline (Mitrinermine) is an alkaloid isolated from Crocus sativus and is widely used in anti-inflammatory and neuroprotective studies.Formule :C22H28N2O4Degré de pureté :99.44%Couleur et forme :Red Brown Or White Fine PowderMasse moléculaire :384.47Indole-3-carbinol
CAS :Indole-3-carbinol (I3C), a naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, inhibits NF-κB and IκBα kinaseFormule :C9H9NODegré de pureté :100% - 97.06%Couleur et forme :SolidMasse moléculaire :147.17Coronalolic acid
CAS :Coronalolic acid is a natural product extracted from the Gardenia sootepenesis Hutch. It inhibits TNF-α-induced NF-κB activity and NO production.Formule :C30H46O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :470.681-Isomangostin
CAS :1-Isomangostin has cytotoxic and anticomplementary activities.Formule :C24H26O6Degré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :410.462,5-Dihydroxyacetophenone
CAS :2,5-Dihydroxyacetophenone has anti-anxiety, neuroprotective, anti-inflammatory properties, and modulates cell signaling and melanogenesis.Formule :C8H8O3Degré de pureté :99.75%Couleur et forme :Yellow PowderMasse moléculaire :152.15NF-κB-IN-12
NF-κB-IN-12 (compound 3h) serves as a potent inhibitor of NF-κB, exhibiting an IC50 value of 1.02 μM. It is applicable for research in acute lung injury [1].Formule :C30H26N6O5SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :582.63Zimlovisertib
CAS :Zimlovisertib (PF-06650833) is an effective, selective and orally active inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4).Formule :C18H20FN3O4Degré de pureté :98.21%Couleur et forme :SolidMasse moléculaire :361.37Ref: TM-TQ0167
1mg35,00€5mg67,00€10mg115,00€25mg224,00€50mg404,00€100mg655,00€200mg910,00€1mL*10mM (DMSO)73,00€IRAK4-IN-25
IRAK4-IN-25 (compound 38), a potent oral IRAK4 inhibitor (IC50 = 7.3 nM) with low clearance (Cl = 12 mL/min/kg), effectively suppresses pro-inflammatoryFormule :C23H25N5O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :435.48JC124
CAS :JC124 is an inhibitor of NLRP3 Inflammasome and exhibits neuroprotective and anti-inflammatory activities.Formule :C17H19ClN2O4SDegré de pureté :98.54%Couleur et forme :SolidMasse moléculaire :382.86Ref: TM-T25548
1mg64,00€5mg145,00€10mg226,00€25mg379,00€50mg538,00€100mg730,00€200mg938,00€1mL*10mM (DMSO)160,00€RIPK3-IN-4
CAS :RIPK3-IN-4 (Compound 42) is a RIPK3 inhibitor that mitigates necroptosis, inflammatory responses, and HK-2 cell damage.Formule :C24H18BrFN4O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :541.39
